Kaihanga paura Agomelatine Nama CAS: 138112-76-2 99% te parakore iti rawa mō ngā kai tāpiringa
Ataata Hua
Ngā Tawhā Hua
| Ingoa hua | Agomelatine |
| Ingoa kē atu | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Nama CAS | 138112-76-2 |
| Tātai ngota | C15H17NO2 |
| Taumaha ngota | 243.3082 |
| Te parakore | 99.0% |
| Āhua | Paura mā |
| Te tākai | 1kg/pēke 25kg/pahu |
| Tono | Ngā rauemi mata o te hua hauora |
Whakataki hua
I whakarewaina tuatahitia a Agomelatine ki Ūropi i te tau 2009, ā, kua whakaaetia inaianei kia whakamahia i roto i te neke atu i te 70 whenua. He rerekē ki ngā rongoā ārai pouri tuku iho, ka mahi te agomelatine mā te aro ki ngā kaiwhakawhiwhi melatonin me te serotonin i roto i te roro. Mā te mahi hei agonist i ngā kaiwhakawhiwhi melatonin, ka āwhina te agomelatine ki te whakataurite i ngā tauira moe kua whakararuraruhia e pā ana ki te pouri. Ehara i te mea ka āwhina noa tēnei tikanga ki te whakapai ake i te kounga moe engari ka āwhina hoki ki te whakahoki mai i ngā manawataki circadian tūturu. Hei tāpiri, ka mahi te agomelatine hei hoariri ki ētahi kaiwhakawhiwhi serotonin (ngā kaiwhakawhiwhi 5-HT2C). Ka whakarei ake tēnei mahi takirua ahurei i te wātea o te serotonin i roto i te roro, he neurotransmitter e kawenga ana mō te whakahaere i te wairua. Mā te whakahaere i ngā taumata serotonin, ka taea e te agomelatine te mahi hei rongoā ārai pouri whai hua, hei whakaora i ngā tohu pēnei i te pouri, te ngaro o te hiahia, ngā kare ā-roto o te hara, te koretake rānei. Hei tāpiri, tera pea ka whakaratohia e te agomelatine ētahi atu painga. E kī ana ngā rangahau tera pea ka āwhina i te whakapai ake i te mahi hinengaro. E whakaatu ana ngā rangahau i tōna kaha ki te whakarei ake i te mahara, te aro, me te mahi whakahaere, ka waiho hei wāhanga whakahihiri mō ngā rangahau a meake nei.
Āhuatanga
(1) Teitei o te parakore: Ka taea e te Agomelatine te whiwhi hua tino parakore mā roto i ngā tukanga whakaputa. Ko te tikanga o te tino parakore he pai ake te wātea o te koiora me te iti ake o ngā tauhohenga kino.
(2) Haumarutanga: He tino haumaru, he iti noa ngā pānga kino.
(3) Te Pūmautanga: He pai te pumau o te Agomelatine, ā, ka taea e ia te pupuri i tōna kaha me tōna pānga i raro i ngā taiao me ngā tikanga rokiroki rerekē.
Ngā tono
He rongoā ārai pouri te Agomelatine, ā, he rongoā ārai hoki mō te melatonin. Ka whakaitihia ngā tohu pouri mā te whakahaere i ngā kaiwhakawhiwhi MT1 melatonin (ka whakaiti i ngā tohu whakaoho cortical) me ngā kaiwhakawhiwhi MT2 (te auau moe circadian) me ngā taumata serotonin. Ina tangohia i te pō, ka whai i te auau tūturu o te tukunga melatonin, ā, ka taea te whakapai ake i te kounga o te moe. Ka pakaru tana tikanga mahi i roto i te pūnaha tuku monoamine tuku iho. Ka whakahohehia e ia ngā kaiwhakawhiwhi melatonin MT1 me MT2, ā, ka ārai i ngā kaiwhakawhiwhi 5-HT2C. Ka whakapai ake i te kounga o te moe, ka whakahoki mai i te auau koiora, ā, he pānga ārai pouri; i roto i ēnei, mā te ārai i ngā kaiwhakawhiwhi 5-HT2C i runga i te membrane postsynaptic, ka taea te whakanui ake i te tukunga o te DA me te NE i roto i te prefrontal cortex, ka puta he pānga ārai pouri. Ina noho tahi te MT agonism me te 5-HT2C receptor antagonism, ka taea te whakaputa i tētahi pānga synergistic ahurei, ka whakatairanga i te tukunga o te DA me te NE i roto i te rohe roro PFC, ka whakapakari ake i te pānga ārai pouri. Hei tāpiritanga, ka taea e te agomelatine te whakatairanga i te tukunga o te neurotrophic factor i ahu mai i te roro i roto i te PFC me te aukati i te tukunga o te glutamate i puta mai i te ahotea i roto i te rohe roro o te amygdala.












