Kei tua atu i tō whakaaro te mana o te taurine!!

Nō nā tata nei, kua whakaputaina ngā rangahau mō te taurine i roto i ngā puka rangahau matua e toru, arā, ko Science, Cell, me Nature. Kua whakakitea mai e ēnei rangahau ngā mahi hou a te taurine - te ārai i te koroheketanga, te whakapai ake i te pānga o te maimoatanga mate pukupuku, me te ārai i te momona.

I te marama o Hune 2023, i whakaputa ngā kairangahau o te National Institute of Immunology i Īnia, te Whare Wānanga o Columbia i te Hononga o Amerika, me ētahi atu whare wānanga i ngā tuhinga i roto i te hautaka mātauranga o te ao, Science. E kī ana te rangahau ko te korenga o te taurine te take o te koroheketanga. Mā te tāpiri taurine ka taea te whakaroa i te koroheketanga o ngā nematode, ngā kiore, me ngā makimaki, ā, ka taea hoki te whakaroa i te roanga o te oranga hauora o ngā kiore waenga-pakeke mā te 12%. Ngā Taipitopito: Pūtaiao: Mana kei tua atu i tō whakaaro! Ka taea hoki e te taurine te whakakore i te koroheketanga me te whakaroa i te roanga o te oranga?

I te marama o Āperira 2024, i whakaputa a Ahorangi Zhao Xiaodi, Ahorangi Tuarua Lu Yuanyuan, Ahorangi Nie Yongzhan, me Ahorangi Wang Xin o te Hōhipera Xijing o te Whare Wānanga Hauora Hōia Tuawhā i ngā tuhinga i roto i te hautaka mātauranga o te ao rongonui, Cell. I kitea i roto i tēnei rangahau ka whakataetae ngā pūtau pukupuku ki ngā pūtau CD8+ T mō te taurine mā te whakaputa nui i te kaikawe taurine SLC6A6, e hua ai te mate me te ngenge o ngā pūtau T, ka arahi ki te mawhiti o te ārai mate pukupuku, ā, ka whakatairanga i te whanaketanga me te hokinga mai o te pukupuku, i te mea ka taea e te tāpiringa Taurine te whakahohe anō i ngā pūtau CD8+ T kua ngenge me te whakapai ake i te whai huatanga o te maimoatanga mate pukupuku.

I te 7 o Ākuhata, 2024, i whakaputa te tīma a Jonathan Z. Long o Te Whare Wānanga o Stanford (ko Tākuta Wei Wei te kaituhi tuatahi) i tētahi pepa rangahau ko te taitara: PTER is an N-acetyl taurine hydrolase that regulates feeding and momonatanga in the top international academic journal Nature.

I kitea e tēnei rangahau te tuatahi o ngā matūriki N-acetyl taurine hydrolase i roto i ngā kararehe whakangote, arā, ko te PTER, ā, i whakaū i te mahi nui a te N-acetyl taurine ki te whakaiti i te kai e kainga ana me te ārai i te momona. I te heke mai, ka taea te whakawhanake i ngā aukati PTER kaha me te whiriwhiri hei rongoā i te momona.

He whānuitia te kitea o te taurine i roto i ngā kiko o ngā kararehe me ngā kai maha, ā, he nui ngā kukū e kitea ana i roto i ngā kiko whakakorikori pērā i te ngākau, ngā kanohi, te roro, me ngā uaua. Kua whakaahuatia he mahi pūtau me te mahi ā-tinana a te taurine, inā koa i roto i te horopaki o te homeostasis metabolic. Ko te whakahekenga ira o ngā taumata taurine ka arahi ki te ngoikore o te uaua, te whakaiti i te kaha whakakori tinana, me te ngoikore o te mitochondrial i roto i ngā kiko maha. Ka whakaitihia e te tāpiringa taurine te ahotea redox mitochondrial, ka whakapai ake i te kaha whakakori tinana, ā, ka pehi i te taumaha o te tinana.

Kua kukumehia te aro nui ki te matū koiora me te whākōkī o te pākia o te taurine. I roto i te ara hangai taurine taketake, ka whakakōkīhia te cysteine ​​e te cysteine ​​​​dioxygenase (CDO) me te cysteine ​​​​sulfinate decarboxylase (CSAD) hei whakaputa i te hypotaurine, ā, muri iho ka puta te taurine mā te whakahāngaitanga e te flavin monooxygenase 1 (FMO1). Hei tāpiri, ka taea e te cysteine ​​​​te whakaputa hypotaurine mā te ara rerekē o te cysteamine me te cysteamine dioxygenase (ADO). Kei raro iho i te taurine he maha ngā matū taurine tuarua, tae atu ki te taurocholate, te tauramidine, me te N-acetyl taurine. Ko te whākōkī anake e mōhiotia ana hei whakakorikori i ēnei ara kei raro iho ko te BAAT, e whakakotahi ana i te taurine me te bile acyl-CoA hei whakaputa taurocholate me ētahi atu tote bile. Haunga te BAAT, kāore anō kia whakatauhia ngā tuakiri ngota o ētahi atu whākōkī e takawaenga ana i te pākia o te taurine tuarua.

He mea tino whakamere te N-acetyltaurine (N-acetyl taurine) engari he iti noa te rangahau i te matū matū tuarua o te taurine. Ko ngā taumata N-acetyl taurine i roto i ngā wai koiora ka whakahaeretia e ngā raruraru ā-tinana maha e whakanui ana i te rere o te taurine me/ranei te acetate, tae atu ki te whakakori tinana manawanui, te inu waipiro, me te tāpiringa taurine kai. Hei tāpiri, he rite te hanganga matū o te N-acetyltaurine ki ngā ngota tohu tae atu ki te neurotransmitter acetylcholine me te acyltaurine ngako mekameka roa e whakahaere ana i te huka toto, e kī ana tera pea ka mahi hei matū matū tohu. Ka mahi te hua. Heoi, kāore anō kia mārama te biosynthesis, te whakahekenga, me ngā mahi pea o te N-acetyl taurine.

I roto i tēnei rangahau hou, i tautuhia e te tīma rangahau te PTER, he whākōkī korekore kāore i te mōhiotia te mahi, koia te N-acetyl taurine hydrolase matua o te kararehe. I roto i te vitro, i whakaatuhia e te PTER recombinant he whānuitanga whāiti o te matū me ngā herenga nui. I roto i te N-acetyl taurine, ka waikurahia hei taurine me te acetate.

Ko te patu i te ira Pter i roto i ngā kiore ka hua ake te ngaronga katoa o te ngohe waikura o te N-acetyl taurine i roto i ngā kiko, me te pikinga ā-tinana o te ihirangi N-acetyl taurine i roto i ngā momo kiko.

E hono ana te wāhi PTER tangata ki te taupū papatipu tinana (BMI). I kitea anō e te tīma rangahau, i muri i te whakaohooho me te pikinga o ngā taumata taurine, i whakaatuhia e ngā kiore Pter knockout te iti o te kai e kainga ana, ā, he ātete ki te momona i puta mai i te kai. me te whakapai ake i te homeostasis glucose. Nā te tāpiritanga o te N-acetyl taurine ki ngā kiore momo-mohoao momona i whakaiti i te kai e kainga ana me te taumaha o te tinana i roto i te huarahi e whakawhirinaki ana ki te GFRAL.

Mā ēnei raraunga ka whakanohohia te PTER ki te pūnga whākōkī matua o te pākia tuarua o te taurine, ā, ka whakakitea ngā mahi a te PTER me te N-acetyl taurine ki te whakahaere taumaha me te taurite pūngao.

I te nuinga o te wā, i kitea e tēnei rangahau te acetyl taurine hydrolase tuatahi i roto i ngā kararehe whakangote, arā, ko te PTER, ā, i whakaū i te mahi nui a te acetyl taurine ki te whakaiti i te kai e kainga ana me te ārai i te momona. I te heke mai, e matapaetia ana ka whakawhanakehia he aukati PTER kaha, whiriwhiri hoki hei rongoā i te momona.