I ngā tau tata nei, kua piki haere te hiahia ki ngā matū taiao hei whakarei ake i te hauora me te oranga whānui. Ko te Urolithin A me te urolithin B he matū taiao e rua i ahu mai i ngā ellagitannins e kitea ana i roto i ētahi hua me ngā nati. Nā ō rāua āhuatanga ārai-mumura, ārai-waikawa, me te hanga uaua, he mea whakamere ēnei matū hei whakatairanga i te hauora whānui. Ahakoa he rite ngā āhuatanga o te urolithin A me te urolithin B, he rerekētanga nui anō hoki ō rāua.
Ko te Urolithin A me te B he matū whakaputa i roto i te tinana tangata hei hua o te nakunaku o ētahi wāhanga kai, inā koa ko ngā ellagitannins. Kei roto i ngā hua me ngā nati maha ngā Ellagitannins, tae atu ki ngā pamekaranete, ngā rōpere, ngā rāhipere, ngā parakipere, me ngā nati wōnati. Heoi, he iti noa te ōrau o te taupori kei a rātou ngā huakita puku e taea ai te huri i ngā ellagitannins hei urolithins, ka rerekē ai ngā taumata urolithin i roto i te tangata.
Mō te hunga e uaua ana ki te whakatutuki i ō rātou hiahia konupora mā te kai anake, ka taea e ngā tāpiringa konupora te whai hua ki te hauora i roto i ngā huarahi maha, ā, ka puta mai i roto i ngā āhua pēnei i te konupora waikura, te konupora threonate, te konupora taurate, me te konupora glycinate. Heoi, e taunakihia ana kia kōrero ki tētahi tohunga hauora i mua i te tīmatanga o tētahi tikanga tāpiringa hei karo i ngā taunekeneke me ngā raruraru pea.
Ko te Urolithin A te ngota ngota tino nui i roto i te whānau urolithin, ā, kua tino rangahauhia ōna āhuatanga antioxidant me te anti-inflammatory. Kua whakaatuhia e ngā rangahau ka taea e te urolithin A te whakapai ake i te mahi mitochondrial me te ārai i te kino o te uaua. Hei tāpiri, kua whakaatuhia e ngā rangahau ka taea e te urolithin A te aukati i te tipu pūtau me te whakaoho i te mate pūtau i roto i ngā momo momo pūtau matepukupuku.
Kua arohia te Urolithin B e ngā kairangahau mō tōna kaha ki te whakapai ake i te hauora o te puku me te whakaiti i te mumura. E whakaatu ana ngā rangahau ka taea e te urolithin B te whakarei ake i te kanorau o ngā moroiti puku me te whakaiti i ngā cytokine pro-inflammatory pēnei i te interleukin-6 me te tumor necrosis factor alpha. Hei tāpiri, kua kitea he āhuatanga tiaki io pea te urolithin B, me ngā rangahau e whakaatu ana ka taea e ia te āwhina ki te aukati i ngā mate neurodegenerative pēnei i te mate a Parkinson me te mate a Alzheimer.
Ahakoa he rite ngā āhuatanga o te urolithin A me te urolithin B, he rerekētanga nui kei a rāua. Hei tauira, kua whakaatuhia he pai ake te urolithin A hei ārai-mumura me te ārai-waipiro i te urolithin B. I tetahi atu taha, i kitea he pai ake te urolithin B ki te ārai i ngā raruraru e pā ana ki te momona, pērā i te ātete ki te insulin me te rerekētanga o ngā pūtau ngako.
He rerekē anō hoki ngā tikanga mahi a te urolithin A me te urolithin B. Ka whakahohe a Urolithin A i te ara peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), e whai wāhi ana ki te mitochondrial biogenesis, ko te urolithin B ia e whakarei ake ana i te ara AMP-activated protein kinase (AMPK), e whai wāhi ana ki te homeostasis pūngao. Ka whai wāhi ēnei ara ki ngā pānga hauora pai o ēnei pūhui.
●Ngā Āhuatanga Ārai-mumura
E mōhiotia ana ko te mumura mau tonu te take o ētahi mate. Kua whakaatuhia he kaha ngā āhuatanga ārai-mumura o te Urolithin A, e whakaiti ana i te hanga o ngā ngota mumura. Mā te pehi i te mumura, ka taea pea e ia te āwhina ki te whakahaere i ngā mate mau tonu pērā i te mate rumatiki, te mate ngakau, me ētahi momo mate pukupuku.
●Hauora me te Kaha o te Uaua
I a tātou e pakeke haere ana, ka noho ko te ngaronga o ngā uaua angaanga hei āwangawanga nui. Kua kitea te kaha o te Urolithin A ki te whakaoho i te tipu o ngā pūtau uaua me te whakarei ake i te mahi uaua, me te whakatairanga i te hauora me te kaha o ngā uaua. He mea pai tēnei mō te hunga e hiahia ana ki te pupuri i te papatipu uaua me te whawhai ki te hekenga o ngā uaua e pā ana ki te koroheketanga.
●Te Hauora me te Roa o te Mitochondrial
He kaha ngā pānga o te Urolithin A ki ngā mitochondria, e kiia nei ko ngā whare hiko o ō tātou pūtau. Ka whakaoho i tētahi tukanga e kiia nei ko te mitophagy, arā, ko te tango whiriwhiri i ngā mitochondria kua pakaru. Mā te whakatairanga i te mahi hauora o ngā mitochondria, ka āwhina pea te urolithin A ki te roa o te ora me te tiaki i ngā āhuatanga e pā ana ki te koroheketanga pērā i ngā mate neurodegenerative.
●Te Mahi Ārai Matewai
He kaha te kaha o te Urolithin B hei ārai i te mate, ā, ka āwhina i te whakakore i ngā rauropi kore utu kino i roto i te tinana. He ngota tino tauhohe ngā rauropi kore utu ka taea te whai wāhi ki te kino o ngā pūtau me te ahotea waikura, e whai wāhi ana ki ngā momo mate. Mā te kaha ārai mate o te Urolithin B ka āwhina i te tiaki i ō tātou pūtau mai i aua kino, ā, ka whakaiti pea i te tūponotanga o ngā mate mau tonu.
●Te Hauora o te Puku me te Whakarerekētanga o te Microbiome
He mea nui te mahi a tō tātou puku ki te hauora whānui, ā, kua puta te urolithin B hei mea matua ki te pupuri i te hauora o te microbiome o te puku. Ka whakatairanga i te tipu o ngā paingangā huakita ā-iwi, ā, ka aukati i te tipu o ngā huakita kino, ā, ka poipoi i tētahi taiao moroiti taurite. E pā ana te moroiti puku pai ki te whakapai ake i te nakunaku, te mahi ārai mate, me te oranga hinengaro.
●Whakatairanga i te hauora o ngā uaua
Kua whakaaturia te kaha o te Urolithin B ki te whakaoho i te mitochondrial autophagy, he tukanga pūtau e āwhina ana ki te tango i ngā mitochondria kua pakaru mai i ngā pūtau. Ka āwhina tēnei tukanga ki te whakapai ake i te hauora me te mahi a te uaua whānui, ā, he mea pea hei tāpiringa mā te hunga e hiahia ana ki te whakapai ake i te mahi tinana. I kitea i roto i tētahi rangahau he pai ake te mahi me te kaha o te uaua i roto i ngā kiore me ngā tāngata nā te urolithin B.
Ka puta ngā Urolithins i roto i ō tātou tinana i muri i te kai i ētahi kai kei roto ngā ellagitannins. Ko ngā puna kai matua o ngā ellagitannins ko:
a)Pamekaranete
Ko ngā pamekaranete tētahi o ngā puna kai momona rawa o ngā ellagitannins, ka hurihia hei urolithin A me te urolithin B e ngā huakita o te puku. Mā te kai i ngā hua pamekaranete, i te wai, i ngā tangohanga rānei ka taea te whakanui ake i te kai o ēnei matū kaha, ka whakarei ake i te hauora o ngā pūtau me te whakaatu i ngā pānga ārai-mumura.
b) Ngā hua
He nui ngā taumata o te ellagitannins i roto i ngā momo hua pēnei i te rōpere, te rāhipere, me te parakipere. Kua whakaatuhia e ngā rangahau ko te kai i ēnei hua oraora ka whakatairanga i te whakaputanga o te urolithin A me te urolithin B i roto i te puku. Ehara i te mea ka whakarei ake i te reka anake te tāpiri i ngā hua ki tō kai engari ka tukuna hoki he painga hauora mō te wā roa.
c) Ngā nati
He puna nui ngā nati, inā koa ngā nati wōnati me ngā nati pīkana, i roto i ngā ellagitannin. Hei tāpiri, he nui ngā ngako hauora, ngā muka, me ētahi atu matūkai nui. Mā te whakauru i ngā nati ki roto i tāu kai o ia rā, ehara i te mea ka puta noa te urolithin A me te B, engari he maha hoki ngā painga hauora mō te ngākau, te roro, me te oranga whānui.
d) Ngā waina kua pakeketia ki te ōki
Ahakoa he mea miharo pea, ko te inu iti i te waina whero kua pakeketia i te ōki ka whai wāhi atu ki te whakaputa urolithin. Ko ngā matū kei roto i ngā oko ōki e whakamahia ana hei whakakororia i te waina ka taea te tango i te wā e pakeke ana, ka whakaranua ki te waina ngā ellagitannins. Heoi, he mea nui kia mahara he pānga kino ki te hauora te inu nui i te waipiro, nō reira ko te whakaōrite te mea nui.
e) Ngā tipu whai kiko i te Ellagitannin
I tua atu i ngā pamekaranete, he nui ngā ellagitannin i roto i ētahi tipu pēnei i te kiri ōki, te rōpere, me ngā rau ōki. Mā te whakauru i ēnei tipu ki roto i tō kai ka āwhina pea ki te whakanui ake i ngā taumata o te urolithin A me te urolithin B i roto i tō tinana, ka tautoko i te hauora o ngā pūtau me te whakapai ake i te oranga whānui.
Hei whakauruurolithin A me te B ki roto i tō momo noho, ko tētahi huarahi whai hua ko te kai i ngā kai he nui ngā ellagitannins. He puna pai ngā pamekaranete, ngā rōpere, ngā rāhipere, me ngā nati wōnati.
Heoi, he mea nui kia mōhio he rerekē te nui o te ellagitannin i roto i ia hua, ā, ehara i te mea he rite tonu te maha o ngā microbiota puku o te katoa e kaha ana ki te huri i ngā ellagitannin hei urolithin. Nō reira, kāore pea ētahi tāngata e whai hua ki te whakaputa urolithin mai i ēnei puna kai. Ko ngā tāpiringa kai tētahi atu kōwhiringa hei whakarite i te nui o te urolithin A me te B e kainga ana.
P: Me pēhea te whakatairanga a te Urolithin A me te Urolithin B i te hauora o ngā mitochondrial?
A: Ka whakahohehia e te Urolithin A me te Urolithin B tētahi ara pūtau e kiia nei ko te mitophagy, e kawenga ana mō te tango i ngā mitochondria kua pakaru mai i ngā pūtau. Mā te whakatairanga i te mitophagy, ka āwhina ēnei matū ki te pupuri i tētahi taupori mitochondrial hauora, he mea nui mō te whakaputa pūngao me te mahi whānui o ngā pūtau.
P: Ka taea te tiki i te Urolithin A me te Urolithin B mā roto i ngā tāpiringa?
Āe, kei te mākete ngā tāpiringa Urolithin A me Urolithin B. Heoi, he mea nui kia mōhio koe he rerekē pea te whai huatanga me te haumaru o ēnei tāpiringa. He mea pai kia kōrero koe ki tētahi tohunga hauora i mua i te tīmatanga o tētahi tāpiringa kai hou.
Whakakape: Hei whakamōhiotanga anake tēnei tuhinga, kaua e kiia he tohutohu hauora. Me kōrero tonu ki tētahi tohunga hauora i mua i te whakamahi i tētahi tāpiringa, i te whakarerekē rānei i tō tikanga hauora.
Wā tuku: Hepetema-13-2023
