5-amino-1-methylquinolinium iodide CAS No.:42464-96-0 98.0% purea min. | taputapu taapiri kaihanga
Tawhā Hua
| ingoa hua | 5-amino-1-methylquinolinium iodide |
| Ko tetahi atu ingoa | NNMTi5-Amino-1-mq iodide 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-umiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| CAS No. | 42464-96-0 |
| tātai rāpoi ngota | C10H11IN2 |
| Te taumaha ngota | 286.11 |
| Maamaa | 98% |
| Te ahua | Parauri ki te whero parauri totoka |
| Te takai | 1kg / putea, 25kg / oko |
| Taupānga | Rauemi Matau Tāpiringa Kai |
Whakataki hua
Ko te NNMTi he whākōkī nui i te wa o te koroheketanga o te uaua kirihiwi, e hono ana ki te whakatikatika i te kino o te ara NAD+, te mahi sirtuin1 dysregulated, me te piki haere o te ngohe pūtau uaua. Ko te NNMTi e whakatairanga ana i te rereketanga o te myoblast in vitro me te whakarei ake i te whakakotahitanga me te whakahou i nga pūtau kakau uaua i roto i nga kiore tawhito. Ko te NNMTi ano he aukati kaha o te nicotinamide N-methyltransferase (NNMT) (IC50 = 1.2 μM), ka herea ki nga toenga o te waahi NNMT. Ko te NNMTi e whakatairanga ana i te rereketanga o te myoblast in vitro me te whakarei ake i te whakakotahitanga me te whakahou i nga pūtau kakau uaua i roto i nga kiore tawhito. I roto i a raatau, ko te cytosolic enzyme nicotinamide N-methyltransferase (NNMT) kua kitea hou ki te whakahaere i nga taumata o te nicotinamide precursors e hiahiatia ana mo te NAD + biosynthesis, na reira ka whai waahi nui ki te whakahaere i te ara whakaora NAD + me te whakawhitinga pūtau.
Āhuahira
(1) Maamaa teitei: Ka taea e te NNMTi te whiwhi i nga hua tino maamaa na roto i nga tukanga whakaputa parakore. Ko te maatanga teitei he pai ake te koiora.
(2) Te Whakaritenga: Ko te NNMTi e tino aro ana ki te NNMT enzyme a ka taea te aukati i tana mahi, na reira ka pa ki te ara metabolic o te nicotinamide.
(3) Te pumau: He pai te pumau o te NNMTi, ka taea e ia te pupuri i tana mahi me te painga i raro i nga taiao rereke me nga tikanga rokiroki.
(4) Nga tumanakohanga whanaketanga: Na nga momo ahuatanga o te NNMT, kua aro nui te whanaketanga me te whanui rangahau me te tono tono.
Nga tono
Ko te NNMTi he kaitautoko N-methyltransferase (NNMT) nicotinamide e whakatairanga ana i te rereketanga o te myoblast. Ka taea hoki te whakamahi i te NNMTi hei taapiri hei awhina i te whakaheke taumaha me te ngako me te whakapai ake i te ngako ate.
