He tukanga tūturu te koroheketanga o ngā mea ora, e tohuhia ana e te hekenga haere o te hanganga me te mahi a te tinana i roto i te wā. He tukanga uaua tēnei, ā, he tino ngāwari ki ngā awe ngawari mai i ngā āhuatanga o waho pērā i te taiao. Hei hopu tika i te tere o te koroheketanga, kua whakarērea e ngā kaipūtaiao te tikanga ine matawhānui tuku iho o ngā tau, o ngā rā rānei, ā, kua arotahi kē ki te taha wā ngawari ake, me te whai kia kitea he māramatanga ngawari ki te tukanga koroheketanga.
I roto i tēnei tūhuratanga, kua whakawhanakehia e ngā kaipūtaiao he raupapa o ngā tohu koiora koroheketanga me te auaha, ā, ko ētahi o ēnei he tino ātaahua te titiro ki ngā tauira methylation DNA. Hei tikanga whakahaere epigenetic matua, ka taea e ngā tauira methylation DNA te mahere tika i te kōtaha koroheketanga o te tangata, ehara i te mea ko te whakaatu noa i ngā huringa hihiri o ngā mōhiohio ira i roto i te tukanga koroheketanga, engari he mea nui hoki i roto i ngā rangahau pūtaiao koroheketanga. taputapu tika. Mā te tātari hohonu o ēnei tohu koiora, ka taea e ngā kaipūtaiao te kite i ngā tikanga ngota i muri i te koroheketanga, ka whakatuwhera i ngā ara hou hei whakaroa i te koroheketanga me te whakatairanga i te koroheketanga hauora.
I te rangi whetu nui o te pūtaiao ārai-pakeketanga, i rere a NMN (nicotinamide mononucleotide) i mua, pērā i te meteor kanapa. Nā tōna tuakiri hei matūtake o NAD+ (nicotinamide adenine dinucleotide) i whakaoho te tini o ngā kaipūtaiao i te hihiri ki te rangahau. Heoi, i te roanga o te wā, ka puta haere tētahi atu whetu kanapa, ko AKG (alpha-ketoglutarate), ā, ka whānui ake te mōhiotanga i roto i te ao o te ārai-pakeketanga me tōna ataahua ahurei me te pūtake pūtaiao.
I roto i tētahi rangahau i whakaputaina ki te puka Nature Metabolism, i whakamāramahia e ngā kaipūtaiao te tikanga o te AKG i roto i te pākia o te pūngao, te mahi mitochondrial me te ārai i te koroheketanga. I tohuhia e te rangahau ka taea e te AKG te whakatairanga tika i te huringa waikawa tricarboxylic me te whakanui ake i te putanga pūngao i roto i ngā pūtau, ā, ka whakarei ake i te oranga whānui o ngā pūtau. Hei tāpiri, i whakaputahia hoki e te puka "Cell Metabolism" ngā hua rangahau mō te kaha o te AKG ki te whakatairanga i te hanga collagen me te whakapai ake i te ngāwari o te kiri, me te whakaū anō i tōna pūmanawa i roto i te mara o te ārai i te koroheketanga.
Te whakahuri i ngā tohu o te wā
He tauira oraora kei roto i tētahi rangahau haumanu mai i Hapani. He wahine waenga-pakeke kua roa e aro nui ana ki te ārai-pakeketanga, i muri i te tango i ngā tāpiringa AKG mō te haurua tau, ehara i te mea ko te āhua o tōna kiri anake i tino pai ake, i tino pakari ake, i tino ngāwari ake hoki, engari ko tōna hauora tinana me tōna āhua hinengaro whānui i tino pai ake. Mā te whakataurite i ngā tohu ā-tinana i mua me muri i te whakamātautau, i kitea e ngā kairangahau kua tino pai ake te mahi mitochondrial a te wahine, he mea e pā tata ana ki te mahi a AKG ki te whakatairanga i te pākia o te pūngao.
Kaitiaki o te hauora io
I arotahi tētahi atu rangahau mai i te Hononga o Amerika ki te mahi tiaki io a AKG. Whai muri i te whiwhinga o te maimoatanga AKG, i whakaatu tētahi kaumātua he ngoikore te hinengaro i te whakapainga nui o ōna pūkenga hinengaro, tae atu ki te whakapainga o te mahara me te arotahi. I kitea e ngā kairangahau mā te hangarau whakaahua roro kua whakahokia mai te mahi mitochondrial neuron o te tūroro, e whakarato ana i te tautoko kaha mō AKG ki te aukati me te rongoā i ngā mate neurodegenerative.
Ngā painga motuhake o AKG
1. Pānga ārai-pakeketanga maha-ahu
He rerekē ki te NMN, e whawhai ana ki te koroheketanga mā te whakanui ake i ngā taumata NAD+, he whānui ake te mahi a AKG ki te ārai i te koroheketanga. Ehara i te mea ka taea e ia te whakatairanga i te pākia o te pūngao me te whakarei ake i te mahi mitochondrial, engari ka whakapai ake hoki i te āhua koroheketanga o te tinana mai i ngā taha maha mā te pā ki te pākia o te waikawa amino me te whakatairanga i te hanga collagen.
2. Te hototahitanga koiora teitei ake me te haumaru
Hei matū hanga noa iho o te tinana tangata, he tino pai te hototahitanga koiora me te haumaru o AKG. Ka taea te mimiti tika me te whakamahi e te tinana tangata me te kore e whai i tētahi tukanga whakawhiti uaua, ka whakaiti i te tūponotanga o ngā pānga kino. Mā tēnei ka haumaru ake, ka pono ake hoki te whakamahinga o AKG i roto i te mara ārai-pakeketanga.
3. He whānuitanga o ngā painga hauora
Haunga te ārai i te koroheketanga, he maha ngā painga hauora o AKG hei whakatairanga i te hauora o ngā pūnaha io me te whakapakari i te ārai mate. Mā ēnei painga hauora anō ka nui ake te ataahua o AKG mō ngā mahi ārai-koroheketanga.
I te hohonu haere tonu o te rangahau pūtaiao me te whanaketanga tonu o te hangarau, ka whānui ake ngā tūmanakohanga whakamahinga o AKG i roto i te ao o te ārai-pakeketanga. Kei te tumanako mātou ki ētahi atu rangahau kounga teitei a muri ake nei hei hura i ngā mea ngaro o AKG, ā, kei te tumanako hoki mātou ki tōna kaha ki te whakakotahi me ētahi atu rautaki ārai-pakeketanga pērā i te NMN hei tautoko tahi i te whakaaro nui me te mana ki te hauora me te roa o te ora o te tangata. I roto i tēnei whakataetae ki te wā, kua whakaatu a AKG i te kaha whakataetae me ngā āheinga mutunga kore.
Ko ngā mahi matua ko:
Ārai-pakeketanga: Ka taea e ia te whakaroa i te tukanga koroheketanga pūtau mā te whakahaere i te ara tohu mTOR, te whakatairanga i te autophagy, te whakapai ake i ngā āhuatanga rerekē o te pākia o te pūmua, me te whakahaere i te epigenetics. Hei tāpiri, ka taea e ia te whakatairanga i te hanga collagen, te tautoko i te tango matū mai i ngā pūtau, te āwhina i te whakahoki mai i ngā taumata kukū konupūmā noa i roto i te toto, te whakateretere i te whakaora patunga, te whakatairanga i te whakatikatika i ngā kiko uaua, me ētahi atu.
Whakapai ake i ngā mate pūmau: Kua whakaatuhia e ngā whakamātautau haumanu he pānga whakapai ake nui tōna ki ngā momo mate pūmau, tae atu ki te osteoporosis, ngā mate neurodegenerative (pēnei i te mate a Parkinson), ngā mate cardiovascular, te mate huka, me te mate pukupuku. Ka whakaoti rapanga matua i ngā pūtake o ngā mate pūmau mā te whakahohe i ngā pūmua roa o te ora i roto i te tinana me te whakatika i te DNA kua pakaru.
Whakapai ake i te ārai mate: Ka taea e ia te whakarei ake i te mahi me te nui o ngā pūtau ārai mate, te whakapai ake i te ārai mate whānui o te tinana, ā, ka āwhina i te tinana kia pai ake te ātete ki ngā mate me ngā mate pāwera.
Whakatairanga i te hauora: He painga anō hoki tō tēnei hua pēnei i te whakatairanga i te pākia o te huka toto me te ngako i roto i te tinana, me te tautoko i te mahi hinengaro hauora o te roro, hei āwhina i te pupuri i te hauora whānui o te tinana tangata.
E tautokona ana ngā pānga ārai-pakeketanga e ngā rangahau pūtaiao. Hei tauira, i te tau 2014, i pūrongo te hautaka rongonui "Nature" mō te wā tuatahi ka taea te whakaroa i te koroheketanga mā te aukati i te mahi a te mTOR; kua whakamātauhia hoki e te rangahau mō ngā pūtau osteosarcoma tangata ka taea e ia te whakatairanga i te autophagy; hei tāpiri, ka taea hoki e ia te whai wāhi ki te hanga o ngā waikawa amino me te whakaiti i te pākia o te pūmua. Ka puta ngā āhuatanga rerekē, ā, ka uru ki ngā tukanga whakahaere epigenetic pērā i te demethylation DNA.
I whakaūtia anō e ngā whakamātautau haumanu tōna haumaru me tōna whai huatanga. Hei tauira, ko te pūrongo whakamātautau haumanu tangata Wāhanga I i tonoa e te Hōhipera NewMed i California e whakaatu ana he pānga whakaora nui tōna ki ngā momo tohumate mate pūmau pērā i te kore moe, te ngaronga mahara, te ngoikore o te whatukuhu, ngā pānga whiu, ā, ka taea hoki te rongoā i te poto o te manawa, te ngenge, me ētahi atu tohumate i puta mai i te mate korona hou. He pānga tino pai hoki tōna ki ngā pānga whiu pērā i te maremare.
Nā tōna whai huatanga whakamiharo me tōna haumaru, kua riro i te mākete te aro me te whakamoemiti whānui. He maha ngā kaiwhakamahi kua kōrero mō ngā whakapainga nui ki ō rātou āhua tinana i muri i te tangohanga, pērā i te kaha ake, te kiri mārō ake, me te kiri ngāwari ake, me ētahi atu. I taua wā anō, kua mōhiotia, kua tautokona hoki tēnei hua e te maha o ngā umanga me ngā tohunga whai mana.
Hei whakarāpopototanga, he hua ārai-pakeketanga pūtaiao, haumaru, ā, whai hua hoki te Calcium Alpha ketoglutarate. Ka tutuki ngā pānga ārai-pakeketanga, ā, ka whakapai ake i ngā tohu o ngā mate pūmau maha mā roto i ngā huarahi maha. He kōwhiringa pai mō te hunga e whai ana i te hauora me te roa o te ora.
Wā tuku: Hōngongoi-08-2024
