Tāpiringa kai - He matū hou mō te roa o te ora me te ārai i te koroheketanga: Calcium Alpha-ketoglutarate

Konupūmā Āra Ketoglutarate (AKG) he matū takawaenga o te huringa waikawa tricarboxylic, ā, e whai wāhi ana ki te hanga waikawa amino, huaora, me ngā waikawa waro me te pākia o te pūngao. Ka taea te whakamahi hei tāpiringa kai, ā, he whānui ngā tono. Haunga ōna mahi koiora i roto i te tinana tangata, he whānui te whakamahinga o te konupūmā alpha-ketoglutarate i roto i te mara rongoā, ā, kua noho hei wāhanga nui o te maha o ngā hua hauora me ngā otinga hauora.

Te mahi a te konupūmā alpha-ketoglutarate

Tuatahi,cte konupūmā ārepa-ketoglutarateHe mahi nui tā te konupūmā α-ketoglutarate i roto i te pākia o te pūngao. Hei hua takawaenga o te huringa waikawa tricarboxylic (huringa TCA), ka whai wāhi te konupūmā α-ketoglutarate ki te tukanga whakaputa pūngao ā-roto. Mā roto i te huringa TCA, ka waikurahia, ka wetewetehia hoki ngā matūkai pēnei i te warowaihā, te ngako, me ngā pūmua hei whakaputa ATP (adenosine triphosphate) hei whakarato pūngao mō ngā pūtau. Hei takawaenga nui i roto i te huringa TCA, ka taea e te konupūmā α-ketoglutarate te whakatairanga i te pākia o te pūngao pūtau, te whakanui ake i te taumata pūngao o te tinana, te āwhina i te whakarei ake i te kaha tinana me te manawanui, me te whakapai ake i te ngenge tinana.

Tuarua, he mahi nui tā te konupūmā α-ketoglutarate i roto i te pākia o ngā waikawa amino. Ko ngā waikawa amino ngā waeine taketake o te pūmua, ā, kei roto te konupūmā α-ketoglutarate i te hurihanga me te pākia o ngā waikawa amino. I roto i te tukanga hurihanga o ngā waikawa amino ki ētahi atu matūkai, ka whakawhiti te konupūmā α-ketoglutarate me ngā waikawa amino hei whakaputa waikawa amino hou, waikawa α-keto rānei, ā, ka whakahaere i te taurite me te whakamahinga o ngā waikawa amino. Hei tāpiri, ka taea hoki e te konupūmā α-ketoglutarate te mahi hei papa whakapūngao mō ngā waikawa amino, te whai wāhi ki te pākia o ngā waikawa amino, me te whakaputa pūngao me te hauhā waro. Nō reira, he mea nui te konupūmā α-ketoglutarate ki te pupuri i te homeostasis o ngā waikawa amino me te pākia o te pūmua i roto i te tinana.

Hei tāpiritanga, he mahi ātete-waikawa te konupūmā ā-ira-ketoglutarate e tango ana i ngā rauropi kore utu, e tiaki ana hoki i ngā pūtau mai i te kino waikura. I taua wā anō, ka taea hoki e te konupūmā ā-ira-ketoglutarate te whakahaere i te mahi a te pūnaha ārai mate, te whakatairanga i te whakahohenga me te tipu haere o ngā pūtau ārai mate, me te whakarei ake i te ātete o te tinana ki ngā mate me ngā mate pāwera. Nō reira, he mea nui te konupūmā ā-ira-ketoglutarate ki te pupuri i te taurite ārai mate o te tinana me te ātete ki ngā mate.

Rangahau mō ngā pānga o te koroheketanga

Ka pāngia tātou katoa e te koroheketanga, ā, he take mōrearea hoki mō te maha o ngā mate, ā, e ai ki ngā tatauranga ā-ipurangi o Medicare, ka piki ake te tūponotanga o te pāngia e te mate i te pakeketanga. Hei whakaiti i te koroheketanga me te whai hua ki te whakaiti i te mōrearea o te mate, kua kitea e te rangahau tētahi matū haumaru me te koiora ka pā ki te koroheketanga - te konupūmā alpha-ketoglutarate.

He matū matū nui te konupūmā alpha-ketoglutarate i roto i tō tātou tinana, e mōhiotia ana mō te mahi a te pūtau i roto i te huringa Krebs, he huringa e tika ana mō te waikura o ngā waikawa ngako me ngā waikawa amino, e āhei ai ngā mitochondria ki te whakaputa ATP (ko te ATP te pūtake pūngao o ngā pūtau).

Kei roto i tēnei ko te utaina o te tukanga konupūmā alpha-ketoglutarate, nō reira ka taea hoki te huri i te konupūmā alpha-ketoglutarate hei glutamate, kātahi hei glutamine, ka taea te āwhina i te whakaoho i te hanganga o te pūmua me te collagen (he pūmua muka te collagen e hanga ana i te 1/3 o ngā pūmua katoa i roto i te tinana, ā, ka āwhina i te tautoko i te hauora o te wheua, te kiri me te uaua).

Ko Ponce De Leon Health, Inc., he kamupene rangahau mō te roa o te ora e aro ana ki te whakakore i te koroheketanga ira, i whakahaere i tētahi rangahau whakahaere maha-tau mō te konupūmā alpha-ketoglutarate i runga i ngā kiore waenga-pakeke, ā, i kitea kua piki ake te roa o te oranga o ngā kiore i roto i te rōpū whakamātautau mā te 12%. He mea nui ake, i whakaitihia te ngoikore mā te 46%, ā, kua piki ake te roa o te oranga hauora mā te 41%. E whakaatu ana ngā taunakitanga kāore e taea e te tāpiringa alpha-ketoglutarate te whakaroa noa i te roa o te oranga engari ka whakaroa hoki i te roanga o te hauora.

He whānuitia ngā whakamahinga o te konupūmā α-ketoglutarate, hei tāpiringa kai maha-mahi, i roto i ngā hua hauora. Nā ōna mahi koiora maha pērā i te ārai-pakeketanga, te ārai-koroheketanga, te whakahaere i te ārai mate me te pākia o ngā waikawa amino, ka waiho hei taputapu kaha hei whakapai ake i te hauora o te tangata. Nā te piki haere o te mōhiotanga ki te tiaki hauora me te hohonu haere o te rangahau pūtaiao, e whakaponohia ana ka nui ake te aro me te whanaketanga o te whakamahinga o te konupūmā α-ketoglutarate i roto i te mara o ngā hua hauora.