Ko te ingoa pūtaiao o te NAD ko te nicotinamide adenine dinucleotide. Kei roto i ngā pūtau katoa o tō tātou tinana te NAD+. He matū me te coenzyme matua i roto i ngā ara metabolic. Ka takawaenga, ka whai wāhi hoki ki ngā tukanga koiora maha. Neke atu i te 300 ngā whākōkī e whakawhirinaki ana ki te NAD+ kia mahi. Heoi, kāore te taumata o te NAD+ e pumau. I a tātou e pakeke haere ana, ka heke te taumata o te NAD+ i roto i ngā pūtau. Ina koa i muri i te 30 tau, ka tino heke te taumata o te NAD+, ka heke te maha o ngā mahi, ā, ka whakaatu i ngā tohu o te koroheketanga. Ko te Nicotinamide riboside chloride he momo huaora B3. Ka taea te huri i te Nicotinamide riboside chloride ki te NAD+ (nicotinamide adenine dinucleotide). Ko tētahi o ngā matū NAD+ tino rangahauhia. He ngāwari te mimiti e te tinana me te whakamahi. He maha ngā rangahau kua whakaatu ko te tāpiri i te NRC ka taea te whakanui ake i ngā taumata NAD+, ka taea ai te kawe mai i ngā painga ki te pūnaha metabolic, te pūnaha cardiovascular me te pūnaha io. He maha te whakamahinga hei tāpiringa kai hei whakatairanga i te hauora me te oranga whānui.
Ko te Nicotinamide riboside chloride (NRC) he mea hanga mai i te huaora B3, he matū koiora hou hoki. He mea tito mai i te ngota huka ribose me te wāhanga huaora B3 ko te nicotinamide (e mōhiotia ana ko te waikawa nicotinic, ko te huaora B3 rānei). Ka taea te kai mā te kai mīti, ika, witi me ētahi atu kai, mā roto rānei i ngā tāpiringa NRC.
Ka taea te huri i te nicotinamide ribose chloride ki te NAD+ (nicotinamide adenine dinucleotide) ā, ka mahi koiora i roto i ngā pūtau. Ko te NAD+ he coenzyme ā-roto nui e whai wāhi ana ki ngā momo tukanga pākia pūtau, tae atu ki te whakaputa pūngao, te whakatikatika DNA, te tipu pūtau, me ētahi atu. I te wā o te koroheketanga o te tinana tangata, ka heke haere te nui o te NAD+. Mā te tāpiritanga o te nicotinamide riboside chloride ka taea te whakanui ake i te taumata o te NAD+, e matapaetia ana ka whakaroa i te koroheketanga o ngā pūtau me ngā mate e pā ana.
Kua whakaatuhia e ngā rangahau mō te nicotinamide riboside chloride he maha ngā mahi koiora kei roto, pēnei i:
Whakapai ake i te pākia o te pūngao, te whakarei ake i te manawanui me te mahi whakakori tinana;
Whakapai ake i te mahi a te pūnaha io me te mahara;
Whakapai ake i te mahi a te pūnaha ārai mate.
I te nuinga, he wāhanga nutraceutical tino whai hua te nicotinamide riboside chloride, ā, he whānui ngā tono mōna.
Hei tāpiritanga, e whakamahia whānuitia ana te nicotinamide ribose chloride i roto i ngā rangahau pūtaiao. Hei matū matua mō te NAD+, ka taea te whakamahi hei ako i te koiora hanga me ngā ara pākia o te NAD+ me ētahi atu take e pā ana. I taua wā anō, ka whakamahia hoki te nicotinamide riboside chloride hei wāhanga o ngā hua hauora me ngā mea whakapaipai hei whakatairanga i te hauora o ngā pūtau me te whakaiti i te koroheketanga o te kiri.
He kaupapa pumau te koroheketanga mō te tangata. E ai ki ngā rangahau a ngā kaipūtaiao, he hononga tata te koroheketanga o ngā pūtau ki te whakahekenga o te ihirangi nicotinamide adenine dinucleotide (NAD). He hononga nui te NAD i roto i te pākia o te tinana me te whakatikatika pūtau. Ehara i te mea ka taea e ia te whakaroa i te koroheketanga anake, engari ka taea hoki te pupuri i te ora o ngā pūtau me te pupuri i te hauora tinana me te hinengaro. engari. I a tātou e pakeke haere ana, ka tere haere te heke o ngā taumata NAD i roto i ō tātou tinana, ā, tera pea ka heke iho i te haurua neke atu i waenga i te 40 me te 80 tau.
He mea tino nui te whākōkī i roto i tō tātou tinana, koinei te wāhanga matua o te pākia o te pūngao pūtau. He aha te hiranga o tēnei? Tata ki ngā tukanga katoa e pupuri ana i te mahi noa o te tinana, pērā i te pākia o te tinana, te whakatikatika, me te ārai mate, me whai wāhi mai tēnei whākōkī. Ina heke ngā taumata o tēnei whākōkī, ka puta mai he maha o ngā tohu me ngā mate e pā ana ki te koroheketanga, pērā i ngā mate pākia o te tinana, te ngoikore o te mahi ārai mate, te hekenga o te hinengaro, me ētahi atu. He ingoa roa tō tēnei whākōkī nui: nicotinamide adenine dinucleotide, NAD+ rānei.
I roto i te poto, ko te whakahekenga o te NAD+ i roto i te tinana he tikanga mō te koroheketanga. Nō reira, ka taea e tātou te tāpiri i te NAD+ ki te tinana hei whakaroa i te koroheketanga? Ki te tāpiri tika koe i te NAD+, e kore e taea e te tinana tangata te mimiti, ā, ka pā he pānga kino ki a ia. Nō reira, i tahuri te aro o te tangata ki te matū matua o te NAD+: te nicotinamide ribose chloride (NRC).
Ko te Nicotinamide riboside chloride he momo huaora B3, ā, ko tētahi o ngā matūmua NAD+ e tino rangahauhia ana. He ngāwari te mimiti me te whakamahi e te tinana. He maha ngā rangahau kua whakaatu ko te tāpiringa NR ka taea te whakanui ake i ngā taumata NAD+, ā, ka taea hoki e tēnei te kawe mai i ngā painga ki ngā pūnaha pākia o te tinana, te pūnaha ngākau me te pūnaha io.
He kupu kino te ingoa mō te kupu "anti-aging". Me te mea nei kei te ngana tātou ki te aukati i tētahi mea kua tīmata kē te mahi, kāore rānei e taea e tātou te awhi i ngā wāhanga o tātou e tika ana kia arohaina e tātou. Engari ko te mea pono, ka puta ngā huringa pākia i raro i te kiri i mua i te kitenga o ngā pānga o te koroheketanga. Ko te whiriwhiri ki te whakatata atu ki tō tātou hauora mai roto ki waho pea koinei te mea e hiahiatia ana e tātou hei whakapai ake i te āhua o tō tātou koroheketanga.
Ina hoki, ko tētahi o ngā tohu o te koroheketanga ko te tukanga e mōhiotia ana ko te "mitochondrial dysfunction," he kupu e pā ana ki te ngaronga whānui o te pūngao me te whai huatanga o ō tātou pūtau i roto i te wā. Koinei pea tētahi o ngā take e koroheke ai tātou. Mena ko ngā mitochondria te pūtake o tō tātou koroheketanga, he mea tika kia rangahauhia ngā huarahi katoa hei pupuri i a rātou kia mahi tonu mō te roa e taea ai.
Akohia ngā kōrero mō ngā mitochondria.
Kei roto i te nuinga o ngā pūtau katoa ēnei whekau iti, āhua rerekē e kiia nei ko te mitochondria—te "pūngao o te pūtau." Ko ēnei whekau iti te kawenga mō te whakaputa i te 90% o te pūngao e hiahiatia ana e ō tātou tinana. Ko ngā mitochondria te take e ora ai tātou i ēnei rā hei kararehe uaua, kaua hei huakita.
Kāore tātou i te mōhio tonu ki te hiranga o ngā mitochondria ki tō tātou hauora. Ko tētahi huarahi matua hei pupuri i te hauora o ō mitochondria ko te ngota e kiia nei ko te NAD+ (nicotinamide adenine dinucleotide). Ka whakaputa noa ā tātou pūtau i te NAD+, ā, ka whakamahia tonutia e tātou i te roanga o te rā.
E mōhio ana hoki tātou ka heke te nui o te NAD+ i a tātou e pakeke haere ana. I te kitenga o ngā kairangahau ko te NAD+ pea te mea nui hei pupuri i te hauora o ō tātou pūtau, ka rapu huarahi rātou hei whakamahi pai i taua mea.
E mōhio ana ngā kairangahau e rua ngā huaora ka tīmata i te tukanga matū o te whakanui ake i te NAD+: ko te niacin me te niacinamide. I kitea ēnei i ngā tau 1930 hei rongoā i te pellagra, he mate kore huaora B3 ka mate pea.
I te tekau tau atu i 1950, ka whakamahia te niacin hei rongoā mō te cholesterol tiketike. Heoi, kua kitea ko te kai i te nui o te niacin ka pāngia e te whero o te kiri, he mea whakarihariha, he mea whakarihariha hoki.
Kāore te niacinamide e whakawerawera i te kiri, ā, e ai ki te ariā, he maha ngā painga ōrite e puta mai ana, engari ka aukati i te whakahohenga o ngā pūmua whakatikatika pūtau nui e kiia nei ko ngā sirtuin. Kāore te niacinamide me te niacin i rite te whai huatanga ki tā ngā kairangahau i tumanako ai.
Ahakoa he matū mua o te NAD+ ēnei huaora e rua, ehara i te otinga tino pai. Nā ngā pānga kino o te niacin me te whai huatanga o te nicotinamide, kāore anō kia kitea e ngā kairangahau he tāpiringa huaora e ranea ana hei whakanui ake i ngā taumata NAD+.
Te kitenga o te nicotinamide riboside.
I kitea tētahi atu momo huaora B3, ko te nicotinamide riboside te ingoa, i roto i te rewena i ngā tau 1940. Engari tae noa ki ngā tau tōmua o te tau 2000 ka tīmata ngā kaipūtaiao ki te kite i te kaha o tēnei huaora tuatoru, B3, ki te whakanui ake i te NAD+, engari ki te whakapai ake hoki i te hauora o te tangata. I te tau 2004, i kitea e tētahi rōpū rangahau o te Kāreti o Dartmouth ko te nicotinamide riboside, pērā i tōna teina huaora B3, he matū mua ki te NAD+.
I kitea e tētahi rōpū rangahau i arahina e Tākuta Charles Brenner i whakapiki ake te nicotinamide riboside i te NAD+ i roto i ngā kiore, ā, he maha ngā painga hauora i pā ki ngā kiore.
I whakaatuhia e ngā kiore ngā mea katoa mai i te whakapai ake i te huka toto me te taumata cholesterol ki te whakaiti i te kino o ngā io me te ātete ki te pikinga taumaha. I kitea e Tākuta Charles Brenner he tino whakatenatena ēnei hua, ā, i tangohia e ia te taahiraa e whai ake nei kia mārama ai ki ngā pānga o te nicotinamide riboside ki te hauora o te tangata.
I te tau 2014, ko Tākuta Brenner te tangata tuatahi i tango i te nicotinamide riboside hei tāpiringa. He mea whakatenatena anō hoki ngā hua. Nā tēnei momo huaora B3 kāore i te tino mōhiotia i whakanui ake i ana taumata NAD+ i roto i te haumaru, i te tere, ā, kāore he pānga kino.
Ka whakamahia e te Nicotinamide riboside tētahi ara ahurei hei whakaputa i te NAD+ kāore e whakamahia ana e tētahi atu huaora B3.
Ka taea hoki e te nicotinamide riboside te whakahohe i ngā pūmua sirtuins e whakatairanga ana i te whakatikatika pūtau. I a tātou e pakeke haere ana, ka mahi tonu ēnei sirtuins hei āwhina i ngā pūtau kia kaha tonu.
Ko te noho hauora i a koe e pakeke haere ana, e kore rawa e rite ki te ngāwari o te kotahi huaora, ahakoa he rite te whai huatanga o tētahi ki te nicotinamide riboside. Neke atu i te 100 ngā rangahau e rangahau ana i te nicotinamide riboside, ā, he maha o ēnei e whakaatu ana ko te pikinga o ngā taumata NAD+ e pā ana ki te hauora o te pākia me te uaua i roto i ngā kiore. Kei te haere tonu ngā rangahau atu hei mārama ki te tūranga o te NAD+ ki te tautoko i ētahi atu wero hauora e pā ana ki te koroheketanga, tae atu ki te hekenga o te mahi ate, te pikinga taumaha, ngā taumata insulin me te mahi roro i roto i ngā kiore.
He aha te NAD?
Ko te NAD+ he coenzyme I, he coenzyme e whakawhiti ana i ngā porotona (he tika ake, ko ngā iona hauwai) ā, e whai wāhi ana ki ngā mahi ā-tinana maha pērā i te pākia o ngā rauemi pūtau, te hanga pūngao, me te whakatika i te DNA. Ko te NAD+ he matūkai e tika ana mō te mahi a te pūmua Sirtuin, e kiia nei ko te "roa o te ora" e ngā kaipūtaiao. Ina koa, ka taea e ia te pupuri i te roa o ngā telomere matua, te whakaroa i te tukanga koroheketanga me te whakaroa i te roa o te ora.
Ka taea hoki e te NAD+ te whakatairanga i te whakatikatika ira me te whakaroa i te koroheketanga o ngā pūtau. Ka whakatairanga te NAD+ i te whakahoutanga o ngā pūtau me te ātete ki ngā mate o te pūnaha ārai mate. Ka whakapai ake te NAD+ i te pumau o ngā ira, ā, ka whakaiti i te mōrearea o te mate pukupuku.
Ko rātou ngā hoa pai o ngā whākōkī, e āwhina ana ki te whakakaha i te "mīhini pūtau" e hanga ana i te pūngao e hiahiatia ana mō ngā mahi nui katoa o tō tinana i te taumata pūtau.
He aha te hiranga o te NAD+?
Nā tōna tūranga nui i roto i te whakaputanga pūngao pūtau, ka kore te NAD+ i roto i tō tinana e whai hua ai te nuinga o ngā mahi a te tinana. Ki te kore he NAD, e kore e taea e ō pukahukahu te tango hāora, e kore e taea e tō ngākau te pupuhi toto, ā, e kore e mahi ngā hononga o tō roro.
Ka āwhina hoki a NAD+ ki te whakatairanga i te whakatikatika DNA me te whakahaere i te mahi a te pūtau mā te mahi tahi me ngā sirtuins me ngā poly(ADP-ribose) polymerases (PARPs), he mea nui ēnei ki te whakahaere i ngā urupare pūtau ki ngā mahi kino pēnei i te kai nui, te inu waipiro, te moe pōrearea, me ngā tauira noho noa. Ngā whākōkī.
NAD+ me te koroheketanga
I te tau 2012, i whakaatuhia e te rangahau i whakahaerehia e te rōpū mai i te Tari Rongoā i Te Whare Wānanga o New South Wales he hononga te pākia o te NAD ki te pakeketanga. E whakaatu ana te rangahau ka heke te taumata NAD+ i roto i te kiko kiri tangata tae atu ki te 50% i waenga i te 40 me te 60 tau, ā, tera pea he wāhi nui te whakahekenga o te NAD+ ki te tukanga koroheketanga.
"I kitea he hononga kino kaha i waenga i ngā taumata NAD+ me te tau i roto i ngā tāne me ngā wāhine," te kī a ngā kairangahau i roto i te pepa.
Hei tāpiri, kei roto te NAD i te manawa pūtau, inā koa i roto i ngā mitochondria, ā, ka whai wāhi ki te hauora whānui o ngā mitochondria. He nui te hiahia pūtaiao ki te whai wāhi o te NAD ki te ngoikore o te mitochondria, tētahi o ngā tohu o te koroheketanga.
I ngā tau tata nei, kua arotahi ngā rangahau ki te mārama ki te tūranga o te NAD i roto i te aro atu ki ēnei hekenga mahi e pā ana ki te koroheketanga.
Ka whakanuia e te Nicotinamide Ribose Chloride ngā taumata NAD+.
Ko te NR he matū mua o te NAD, arā, koia te "poraka hanga" e hangaia ai ngā ngota NAD+. I kitea i te tau 2004 hei matū mua o te NAD+, ā, koinei tētahi o ngā putanga hou o te rangahau NAD+.
He huaora tūturu te NR, he momo hou hoki o te huaora B3, engari kua pāngia kinotia tōna whakamahinga hei tāpiringa e ngā huaora "pakeketanga hauora". He tino whai hua ki te whakanui ake i te NAD, ā, koia tētahi o ngā wawaotanga tino whakahihiri i roto i ngā otinga koroheketanga hauora.
Ka taea e te NR te whakanui ake i ngā taumata NAD+. I whakaatuhia i roto i tētahi whakamātautau haumanu i whakaputaina i roto i te Scientific Reports i piki ake te NAD+ tae atu ki te 50% i muri i ngā wiki e rua o te tango.
Ahakoa kua whakamātauhia i roto i te rongoā te whakanui ake i ngā taumata NAD+ mā te tāpiringa NR, kāore te tāpiringa NAD+ hei wāhanga takitahi i te tino whai hua.
He ngota nui rawa te NAD+, ā, kāore e taea te tomo tika ki ngā pūtau. Engari, me wāwāhi e tō tinana kia iti ake ngā wahi i mua i te whiti i te kiriuhi pūtau. Ka huihuia anō ēnei wāhanga ki roto i te pākahiko.
Nicotinamide riboside (NR) me te te nicotinamide riboside chloride (NRC) He momo huaora B3 ēnei e rua, e mōhiotia ana ko te niacin. He matūkai nui te huaora B3 e whai wāhi nui ana ki ngā mahi maha o te tinana, tae atu ki te whakaputa pūngao, te whakatika i te DNA, me te pākia o ngā pūtau. Ko te NR me te NRC he matūkai matua o te nicotinamide adenine dinucleotide (NAD+), he coenzyme e uru ana ki ngā tukanga koiora maha, pērā i te whakahaere i te whakaputa pūngao pūtau me te tautoko i te whakatika DNA.
Ko te Nicotinamide riboside (NR) he momo huaora B3 kua arohia mō ōna āhuatanga ārai-pakeketanga me te whakanui pūngao. He matū tūturu e kitea ana i roto i ētahi kai i roto i ngā rahinga iti, engari kei te wātea hoki hei tāpiringa kai. E mōhiotia ana te NR mō tōna kaha ki te whakanui ake i ngā taumata NAD+ i roto i te tinana, ka taea ai e tēnei te tautoko i te mahi mitochondrial, te whakarei ake i te whakaputa pūngao pūtau, ā, ka taea pea te whakarato tiaki mai i te hekenga e pā ana ki te paheketanga.
Ko te Nicotinamide riboside chloride (NRC) ia, te momo tote o te NR, ā, e whakamahia whānuitia ana i roto i ngā tāpiringa kai. Mā te tāpiri i te chloride ki te NR ka puta te NRC, e whakaponohia ana ka whakarei ake i te pumau me te waatea o te matū. Ko te tikanga o tēnei, tera pea he pai ake te mimiti me te whakamahinga o te NRC i roto i te tinana i te NR anake, ā, tera pea he pānga nui ake ki ngā taumata NAD+ me te mahi pūtau.
Ko tētahi o ngā rerekētanga matua i waenga i te NR me te NRC ko tō rāua hanganga matū. Ko te NR te āhua taketake o tēnei matū, ko te NRC ia he putanga whakarerekētia me te tāpiri i te hauota. Ko te whāinga o tēnei whakarerekētanga he whakanui ake i te wairewatanga me te wātea o te matū, kia māmā ake ai te mimiti me te whakamahi a te tinana.
Mō ngā painga hauora pea, e whakaarohia ana he rite tonu ngā pānga o te NR me te NRC nā te mea ka taea e rāua te whakanui akeNAD+ngā taumata. Kei roto pea i ēnei pānga te whakapai ake i te mahi mitochondrial, te whakapai ake i te pākia o te pūngao, me te tautoko pea mō te hauora pūtau whānui. Heoi, mā te whakamahi i te NRC i roto i te tāpiringa ka pai ake te mimiti me te whakamahinga, ka nui ake pea ngā painga ki te whakataurite ki te whakamahi i te NR anake.
1. Whakarei ake i te whakaputanga pūngao pūtau
Ko tētahi o ngā painga tino kitea onicotinamide riboside chloride ko tana mahi ki te whakarei ake i te whakaputanga pūngao pūtau. Ko te NR te matūtake o te nicotinamide adenine dinucleotide (NAD+), he coenzyme e whai wāhi ana ki te whakaputanga o te adenosine triphosphate (ATP), te moni pūngao matua o te pūtau. he mahi nui. I a tātou e pakeke haere ana, ka heke ngā taumata NAD+, ka iti ake te whakaputanga pūngao pūtau. Mā te tāpiri atu ki te NR, e whakaponohia ana ka taea te whakakī anō i ngā taumata NAD+, ā, mā reira ka tautoko i te pākia pai o te pūngao pūtau.
2. Te mahi me te roa o te oranga o te mitochondria
Ko ngā mitochondria ngā pūngao o te pūtau, e whai kawenga ana mō te whakaputa pūngao me te whakahaere i ngā tukanga pūtau. E whakaatu ana ngā rangahau ka taea e te Nicotinamide Riboside Chloride te tautoko i te mahi mitochondrial mā te whakatairanga i te biogenesis o ngā mitochondria hou me te whakanui ake i tō rātou whai huatanga. He pānga tēnei ki te roanga o te ora me te koroheketanga hauora, nā te mea he mea nui ngā mitochondria e mahi pai ana mō te pupuri i te hauora me te manawanui o ngā pūtau.
3. Te hauora pākia me te whakahaere taumaha
Ko te NAD+ he coenzyme, he ngota tāpiri rānei, e uru ana ki ngā tauhohenga koiora maha. I kitea i roto i tētahi rangahau tata nei ka taea e te tāpiringa nicotinamide ribose te whakaoho i te pākia o te NAD+ i roto i ngā pakeke hauora me ngā kaumātua. Ehara i te mea i pai te aro o ngā kaiuru ki ngā tāpiringa NR, engari i āwhina pea ki te whakaiti i te toto toto me te pakari o ngā uaua. Ko te korenga o te NAD+ tētahi o ngā tino take o te koroheketanga me te maha o ngā mate, ā, e whakaatu ana ngā rangahau he nui te uara rongoā me te kai totika o te whakaora i ngā taumata NAD+.
Mā te whakanui ake i ngā taumata NAD+, ka whai hua te nicotinamide ribose ki te whakahaere i te pākia o te tinana, ngā rahui pūngao, te hanga DNA, me ētahi atu mahi a te tinana.
Hei tāpiritanga, kua whakaatuhia e ngā rangahau ka taea e te tāpiringa NR te whakapai ake i te aro o te insulin, te whakaiti i te mumura, me te whakarei ake i te ngāwari o te pākia o te tinana. Tērā pea he tino whai hua ēnei pānga mō te hunga e hiahia ana ki te whakahaere i ō rātou taumaha me te tautoko i te hauora pākia o te tinana whānui.
4. Te mahi hinengaro me te hauora o te roro
Hei matū mua mō te NAD+, ka tiakina e te nicotinamide ribose ngā pūtau roro mai i te ahotea waikura, ka arahi pea ki ngā mate roro e pā ana ki te koroheketanga. I roto i ngā pūtau roro, ka āwhina te NAD+ ki te whakahaere i te whakaputanga o te PGC-1-alpha, he pūmua e ahua nei ka āwhina ki te tiaki i ngā pūtau mai i te ahotea waikura me te ngoikore o te mahi mitochondrial.
I kitea e ngā kairangahau i roto i ngā kiore, he mahi nui te whakahekenga o te NAD+ ki te mumura o te roro, te kino o te DNA, me te pirau o ngā neuron i roto i te mate a Alzheimer. I roto anō i tētahi rangahau ngongo whakamātautau, i whakanui ake te nicotinamide riboside i ngā taumata NAD+ me te whakapai ake i te mahi mitochondrial i roto i ngā pūtau take o ngā tūroro mate a Parkinson.
E tohu ana hoki ngā rangahau hou i ngā painga hinengaro pea o te nicotinamide riboside chloride. Kei roto te NAD+ i ngā momo tukanga e pā ana ki te hauora o te roro, tae atu ki te tohu neuronal, te whakatikatika DNA, me te tango i ngā pūmua kua pakaru. Mā te tautoko i ngā taumata NAD+, ka āwhina pea te NR ki te pupuri i te mahi hinengaro me te aukati i te hekenga hinengaro e pā ana ki te koroheketanga.
5. Te Mahi Hākinakina me te Whakaora
I kitea i roto i tētahi rangahau i te tau 2019 i whakaputaina i roto i te European Journal of Nutrient Impurities, ko te whakamahi i ngā tāpiringa nicotinamide ribose i whakapai ake i ngā pūkenga tinana me te whakaiti i te ahotea waikura i roto i ngā kaumātua.
I whakatau ngā kairangahau he pai te tāpiringa NR mō te hunga ngoikore te NAD+, e whakamārama ana he aha i whai hua ake ai i ngā kaumātua i ngā pakeke taitamariki.
Tērā pea ka hiahia ngā kaitākaro me ngā kaiwhaiwhai whakapakari tinana ki te mōhio ka taea e te nicotinamide riboside chloride te pā pai ki te mahi hākinakina me te whakaora. He mahi nui tā NAD+ ki te whakahaere i ngā tukanga pūtau e uru ana ki te whakaputa pūngao me te mahi uaua. Mā te tautoko i ngā taumata NAD+, ka taea e te NR te whakarei ake i te manawanui, te whakapai ake i te whakaora uaua, me te whakarei ake i te mahi hākinakina whānui.
Kounga me te Parakore
I te hoko paura nicotinamide riboside chloride, ko te kounga me te parakore te mea nui. Rapua ngā hua i hangaia e ngā kamupene rongonui me ngā kamupene tuatoru kua whakamatautauria mō te parakore me te kaha. Ko te mea pai, me kore he poke me ngā whakakī i roto i ngā hua kia tino whiwhi ai koe i tētahi tāpiringa kounga teitei e whakatutuki ana i ngā painga e hiahiatia ana.
Te inenga me te whakamahinga
I mua i te whakauru i te paura nicotinamide riboside chloride ki roto i tō mahinga o ia rā, he mea nui kia mārama koe ki te horopeta tika me ngā aratohu whakamahinga. He mea nui kia tīmata me te horopeta iti iho, ā, kia piki haere mārire ina hiahiatia, nā te mea kāore e rite te horopeta teitei ki ngā hua pai ake, ā, ka pā mai pea ngā pānga kino. Hei tāpiri, whakaarohia te kōrero ki tētahi tohunga hauora hei whakatau i te horopeta e pai ana mō ō whāinga me ō hiahia hauora.
Ngā painga me ngā whakaaro pea
E whakanuia ana te Paura Nicotinamide Riboside Chloride mō ōna painga pea, tae atu ki te tautoko i ngā taumata pūngao, te mahi mitochondrial, me te hauora whānui o ngā pūtau. E ai ki ngā rangahau, tera pea ka pā ki te koroheketanga me ngā mate e pā ana ki te koroheketanga.
Te haumaru me ngā mahi whakatūpato
Pērā i ngā tāpiringa katoa, he mea nui kia aro nui ki te haumaru me te mārama ki ngā mahi ārai pea. Ahakoa he pai te manawanui ki te nicotinamide riboside chloride i te nuinga o te wā, ka pāngia pea ētahi tāngata e ngā pānga taha ngawari, pērā i te mamae o te puku. Hei tāpiri, ki te mea he mate hauora tōu, kei te tango rongoā rānei koe, kia tino kōrero ki tētahi tohunga hauora i mua i te whakamahi i tēnei tāpiringa kia mōhio ai he haumaru, he tika hoki mō tō āhuatanga whaiaro.
Kōwhiria he kaiwhakarato rongonui
I te hoko i te Paura Nicotinamide Riboside Chloride, he mea nui kia whiriwhiria he kaiwhakarato pono e whakatairanga ana i te kounga, te māramatanga, me te pai o te kiritaki. Rapua ngā kamupene e whakarato ana i ngā taipitopito mō ā rātou tukanga hanga, te rapu rauemi, me ngā whakamātautau tuatoru. Hei tāpiri, whakaarohia te pānui i ngā arotake a te kiritaki me te rapu taunakitanga mai i ngā puna pono hei whakarite kei te hoko koe mai i tētahi kaiwhakarato pono, pono hoki.
Kua uru atu a Suzhou Myland Pharm & Nutrition Inc. ki te pakihi tāpiringa kai mai i te tau 1992. Koinei te kamupene tuatahi i Haina ki te whakawhanake me te hokohoko i te tangohanga kākano karepe.
Me te 30 tau o te wheako, ā, e ārahihia ana e te hangarau matatau me te rautaki R&D tino arotau, kua whakawhanakehia e te kamupene he whānuitanga o ngā hua whakataetae, ā, kua riro hei kamupene auaha mō ngā tāpiringa pūtaiao koiora, te hanga ritenga me ngā ratonga hanga.
Hei tāpiritanga, ko Suzhou Myland Pharm & Nutrition Inc. tētahi kaihanga kua rēhitatia ki te FDA. He hou, he maha ngā mahi a ngā rauemi R&D a te kamupene, ngā whare whakaputa, me ngā taputapu tātari, ā, ka taea te whakaputa matū mai i te mirikaramu ki te tana i te tauine, me te tutuki i ngā paerewa ISO 9001 me ngā whakaritenga whakaputa GMP.
P: He aha te paura nicotinamide riboside chloride?
A: Ko te Paura Nicotinamide Riboside Chloride he momo huaora B3 kua rangahaua mō tōna kaha ki te tautoko i te whakaputa pūngao pūtau me te pākia o te tinana. He maha ngā wā ka whakamahia hei tāpiringa kai hei whakatairanga i te hauora me te oranga whānui.
P: He aha ngā painga pea o te paura nicotinamide riboside chloride?
A: Ko ētahi o ngā painga pea o te Nicotinamide Riboside Chloride Powder ko te tautoko i te mahi mitochondrial, te whakatairanga i te koroheketanga hauora, me te whakarei ake i te manawanui me te mahi tinana. Tērā pea ka āwhina i te tautoko i te mahi hinengaro me te hauora pūtau whānui.
Q: Kei hea ahau e hoko ai i te paura nicotinamide riboside chloride?
A: Kei te wātea te paura Nicotinamide Riboside Chloride mai i ngā kaihokohoko me ngā toa ipurangi. I te hoko i tēnei tāpiringa, he mea nui kia whiriwhiria he puna pono hei whakarite i te kounga me te haumaru.
Whakakape: He kōrero whānui noa iho tēnei tuhinga, kaua e whakamāramatia he tohutohu hauora. Ko ētahi o ngā kōrero o te pou rangitaki i ahu mai i te Ipurangi, ehara i te mea ngaio. Ko tā tēnei paetukutuku anake he whakarōpū, he whakatakotoranga me te whakatika i ngā tuhinga. Ko te kaupapa o te kawe atu i ētahi atu kōrero, ehara i te mea e whakaae ana koe ki ōna tirohanga, e whakaū ana rānei i te pono o ōna ihirangi. Me kōrero tonu ki tētahi tohunga hauora i mua i te whakamahi i tētahi tāpiringa, i te hanga rānei i ngā huringa ki tō tikanga tiaki hauora.
Wā tuku: 14 o Ākuhata 2024
