Me pēhea te whakanui ake i te kaha o tō roro e te Glycerylphosphocholine?

Glycerylphosphocholine (GPC, e mōhiotia ana ko L-alpha-glycerylphosphorylcholine, alphacholine rānei)he pūtake tūturu o te choline e kitea ana i roto i ngā momo kai (tae atu ki te waiū ū) me ngā pūtau tangata katoa. He iti noa te choline kei roto. Ko te GPC he ngota wairewa-wai kua whakaatuhia he pūtake kaha ake o te choline haumanu i te choline, te phosphatidylcholine rānei (PC) mai i te kai, i ngā tāpiringa rānei.

Ka mimiti pai te GPC ina hoatu ā-waha, ā, ka wehea i roto i ngā enterocytes ki te glycerol-1-phosphate me te choline. Whai muri i te horomitanga o te GPC, ka tere te piki o ngā taumata choline i roto i te toto, ā, ka noho teitei tonu mō ngā haora 10. Ko te pikinga kukū toto teitei o te choline ka whakaoho i tōna kawe pai puta noa i te arai toto-roro. Ka whakanui ake tēnei i ngā toa choline i roto i ngā neurons, te wāhi e whakamahia ai hei hanga PC me te acetylcholine.

I roto i te hanganga, ko te α-GPC he matū choline e herea ana ki te ngota glycerol mā te rōpū phosphate, ā, he phospholipid kei roto ko te choline. He tino teitei te ihirangi o te choline, tata ki te 40%, ko te tikanga ka taea e te 1000 mg o te α-GPC te whakaputa tata ki te 400 mg o te choline kore utu.

He matūkai nui te Choline i roto i ngā hua miraka me ngā hua manu hei āwhina i ngā pūtau ki te pupuri i ō rātou kiriuhi. He mea nui hoki te Choline hei hanga acetylcholine. Ahakoa ka taea e te alpha-GPC me ētahi atu choline pēnei i te phosphatidylcholine me te lecithin te whakatairanga i te hanga acetylcholine, he pai ake te alpha-GPC nā te mea ka māmā ake te mimiti a ngā pūtau i ngā lipids e whakaratohia ana. Neke atu i te 90% o te phosphatidylcholine ka mimitihia e ngā oko toto lymphatic, ko te α-GPC ka mimitihia e te uaua portal, nō reira he teitei ake te whai huatanga o te mimiti, ā, ka whakatairanga ake i te hanga acetylcholine. He neurotransmitter te Acetylcholine e whai wāhi nui ana ki te whakahaere i te mahi roro me te whakahaere uaua. Ahakoa ka taea e tātou te kai i te choline mā te kai, ka heke te nui o te acetylcholine i te pakeketanga.

Ngā Painga o te GPC e Hangai ana ki te Rangahau

Te mahi a te roro

• Whakapai ake i te mahara, te arotahi me te wā urupare mō ngā kaumātua me ngā taiohi
• Ka whakatairanga i te whakaputanga me te tukunga o te acetylcholine (ACh) mai i ngā neuron me ētahi atu pūtau pea.
• Tērā pea ka ea te hekenga o te ACh i puta mai i te koroheketanga, te korenga o te estrogen (te menopause, me te whakamahi pea i ngā ārai hapūtanga ā-waha)
• Whakapai ake i ngā tauira EEG
• Ka whakanui ake i te hanga o te dopamine, te serotonin me te GABA18.
• Whakapai ake i te mahi mitochondrial i te wā o te ischemia/te ahotea waikura
• Ārai i ngā hekenga e pā ana ki te koroheketanga o te maha o ngā pūtau roro me ngā kaiwhakawhiwhi ACh, te mahi uaua me te whakaputanga o te homoni tipu
• Whakatairanga i te whakaputanga o te homoni tipu i roto i ngā pakeke taitamariki me ngā kaumātua
• Ka whakanui ake i te waikura ngako, te kaha o te uaua me te wā tauhohe, ka whakapai ake pea i te taurite, inā koa i roto i ngā kaumātua.

Te Whakatika Roro me te Tautoko mō te Mate Pāwera/Mate Pōuri

• Whakapai ake i te whakaora o te roro i muri i te whiu, te whara o te roro, me te rongoā whakamoe (i mua me muri i te pokanga).
• Te whakatika i te kiko ārai toto-roro i pakaru i te toto toto tiketike
• Whakapai ake i te hinengaro me te whanonga pāpori i roto i te mate a Alzheimer, te mate wareware vascular/senile, me te mate a Parkinson.
• Whakaitihia te whakaiti i te rahinga o te roro, he rite ki te mate a Alzheimer
• Tērā pea he pai mō ngā mate e hiahia ana ki te whakatika i te myelin me te Duchenne muscular dystrophy. Ngā mahi a te choline i roto i te metabolism o te tangata me te GPC

Ngā āhuatanga ahurei hei puna kaha o te choline, te poraka hanga o te acetylcholine me te matū e whakaoho ana i tōna hanganga me tōna huna.

• He neurotransmitter te Acetylcholine i roto i te roro, he transducer tohu hoki i ētahi atu wāhi o te tinana, he mea nui mō te whakahekenga uaua, te tae kiri, te nekehanga o te puku, me ētahi atu mahi kiko. Kāore i rite ki te choline/PC e whakaratohia ana mā te kai, mā te tāpiringa rānei, i whakaatuhia he pānga whakaohooho nui te tāpiringa GPC ki te hanganga o te ACh me tōna tukunga mai i ngā pūtau cholinergic.

Mā te tāpiritanga o te GPC ka hua ake te whakanui ake i te tohu cholinergic i roto i ngā neurons me ētahi atu pūtau ka whakaputa pea i te acetylcholine. He tino whai hua tēnei ina whakaitihia te maha me te mahi whai hua o ngā neurons cholinergic nā te koroheketanga noa, nā ngā tukanga pirau rānei. Mā te tāpiritanga o te GPC ka taea te whakaea i ētahi wāhanga o ēnei ngoikoretanga nā te mea ka piki tere te choline plasma, ka puta he pānga matū kaha ki ngā whākōkī me ngā kaikawe i roto i ēnei ara.

Poraka hanga o te phosphatidylcholine (PC)

• Nō roto te PC i ngā phospholipids, ā, he wāhanga nui o ngā kiriuhi pūtau me ngā kiriuhi mitochondrial. Ko te kaha o te tāpiringa GPC ki te āwhina i te whakaora i te whiu, me te ārai i te hekenga o te maha o ngā kaiwhakawhiwhi ACh i roto i ngā pūtau io, i ngā roro rānei, he taunakitanga anō tēnei mō tana takoha ki te tiaki i te kiriuhi neuronal mā te hanga PC.

Te hanganga o te sphingomyelin

• Ko te sphingomyelin he wāhanga o te pūkahu myelin e hipoki ana, e ārai ana hoki i ngā neuron me ngā io. Nō reira, he pai pea te tāpiringa GPC i roto i ngā āhuatanga katoa e piki ake ana te hiahia mō te whakatikatika myelin, pērā i te neuropathy, te multiple sclerosis, me ētahi atu āhuatanga e pā ana ki te demyelination me te autoimmunity o te kiko io. Te kawe i te ngako i roto me waho o ngā pūtau

• He mea nui te PC mō te hanga me te tuku i ngā matūriki VLDL. Ka wehe ngā triglycerides i te ate i roto i ngā matūriki VLDL, ā, koinei te take e whakanui ake ai te korenga o te choline i te mōrearea o te mate ate momona. Ka taea te tiki PC mai i ngā puna kai, i ngā tāpiringa rānei; heoi, kāore te PC mō ngā phospholipids me ngā lipoproteins e whiwhi tika mai i te PC e kainga ana, e hangaia ana rānei. Ka hangaia mai i ngā momo matūriki choline (tae atu ki te GPC), nō reira ehara te kai i te PC i te huarahi tino whai hua ki te whakanui ake i te puna PC o te tinana.
Tautoko i te nekenekehanga o te parāoa

• He mea nui te GPC i roto i te piri o te DHA (waikawa docosahexaenoic), e hanga ana i te PC-DHA. Ka whakamahia te matatini DHA-PC i roto i ngā momo pūtau tino kaha pērā i ngā pūtau mātakitaki mārama o te retina me ngā pūtau parāoa. Ka whakanui te DHA-PC i te rere o te kiriuhi, he mea nui mō te mahi hauora o te parāoa. He nui ngā kukū o te GPC i roto i te parāoa; ka tangohia ngā pūtau epididymal e whakatipu ana i ngā pūtau parāoa mai i te puna GPC ka hanga i te PC-DHA. Mā te iti o te taumata o te GPC me te PC-DHA i roto i te parāoa ka piki ake te mōrearea o te hekenga o te nekenekehanga o te parāoa.

Te Whakataurite i te GPC me te Acetyl-L-Carnitine (ALCAR)

• I roto i tētahi rangahau mō ngā tūroro e pāngia ana e te mate a Alzheimer kua pāngia e te mate, i hua ake i te GPC he whakapainga nui ake i te nuinga o ngā tawhā neuropsychological ki te whakataurite ki te ALCAR. Ahakoa e tautoko ana ngā matū e rua i te pikinga o te acetylcholine, tera pea he pānga tahi i waenga i te tāpiritanga o ngā matū e rua, i te mea ka whakaratohia e te GPC te choline i te mea ka whakaratohia e te ALCAR te wāhanga acetyl mō te hanganga o te acetylcholine.

Te kaha o te mahi tahi i waenga i te GPC me ngā rongoā. Kāore te tāpiringa GPC e whakaarohia ana he pānga kino ki tētahi rongoā i hangaia hei whakapai ake i te mahi a te roro. Inaa, nā ōna painga ki ngā ara cholinergic me te whakapai ake i te mahi a te kiriuhi pūtau neuronal, tera pea ka whakarei ake i ō rātou painga. Ka whakarei ake pea te GPC i ngā pānga o ngā aukati acetylcholinesterase AChE nā te mea ka whakanui ake pea i te nui o te ACh i roto i te kapiti synaptic, engari ko ēnei rongoā ka whakaroa i tōna pirau.

Hei tāpiritanga, e ai ki ngā rangahau kararehe, ka whakarei ake pea te GPC i te hanga o te dopamine, te serotonin, te GABA rānei i roto i te roro, ā, ka whakarei ake pea te GPC i ngā pānga o ngā aukati tango anō o ēnei neurotransmitters.

Ko Suzhou Myland Pharm & Nutrition Inc. he kaihanga kua rēhita ki te FDA e whakarato ana i te paura Alpha GPC kounga teitei, parakore hoki.

I Suzhou Myland Pharm, e whakapau kaha ana mātou ki te whakarato i ngā hua kounga teitei rawa atu i ngā utu pai rawa atu. Kua whakamatautauria rawatia te parakore me te kaha o tā mātou paura Alpha GPC, kia whiwhi ai koe i tētahi tāpiringa kounga teitei ka taea e koe te whakawhirinaki. Ahakoa e hiahia ana koe ki te tautoko i te hauora pūtau, ki te whakapakari i tō pūnaha ārai mate, ki te whakarei ake rānei i te hauora whānui, ko tā mātou paura Alpha GPC te whiringa tino pai.

Me te 30 tau o te wheako, me te mea hoki e ārahihia ana e te hangarau matatau me ngā rautaki R&D kua tino arotauhia, kua whakawhanakehia e Suzhou Myland Pharm he whānuitanga o ngā hua whakataetae, ā, kua riro hei kamupene auaha mō ngā tāpiringa pūtaiao koiora, te hanga ritenga me ngā ratonga hanga.

Hei tāpiritanga, he kaihanga kua rēhitatia ki te FDA a Suzhou Myland Pharm. He hou, he maha ngā mahi a ngā rauemi R&D a te kamupene, ngā whare whakaputa, me ngā taputapu tātari, ā, ka taea te whakaputa matū mai i te mirikaramu ki te tana i te tauine, me te tutuki i ngā paerewa ISO 9001 me ngā whakaritenga whakaputa GMP.