Kei te piki haere te hiahia mō ngā matū taiao i roto i ngā umanga rangahau pūtaiao me ngā umanga rongoā o ēnei rā. Ko te 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), he matū nui i ahu mai i ngā tipu, kua arohia e te tini o te tangata nā tōna kaha koiora nui. Mō ngā kairangahau pūtaiao me ngā umanga, he mea nui kia kitea he kaiwhakarato pono o te Paura 7,8-Dihydroxyflavone. Ko te Paura 7,8-Dihydroxyflavone i whakaratohia e Suzhou Myland kuahe nama CAS o 38183-03-8 me te parakore tae atu ki te 98%, e hoatu ana ki a koe he kōwhiringa pono.
7,8-Dihydroxyflavone(e mōhiotia ana ko te 7,8-DHF, ko te proflavonoid rānei) he ngota ngota tūturu nō te akomanga flavonoid o ngā matū. Kei roto i ngā rau o Godmania aesculifolia, Tridax procumbens me te primula.
He matū waro te 7,8-DHF, ko tōna tātai ngota C15H10O4. Ka wairewa i roto i ngā whakarewa waro, ā, he rite tonu te tae, te kakara me te reka ki ngā matū flavonoid.
Kua puta ake te 7,8-DHF hei matū nootropic whai hua. Kua whakaatuhia e ia he whānuitanga o ngā pānga neuropharmacological i roto i ngā rangahau haumanu-mua, tae atu ki te whakapai ake i te mahara, te whakatairanga i te neurogenesis me te aukati i te neurodegeneration.
Hei kaiwhakaoho ngota iti kaha, whiriwhiri hoki mō te tropomyosin receptor kinase B (TrkB), kua whakaatuhia e te proflavin tōna whai huatanga ki ngā tauira kararehe ki te whawhai ki ngā momo mate, tae atu ki te mate a Alzheimer.
Ko ngā flavonoid he momo matū polyphenolic e kitea ana i roto i ngā momo huarākau, huawhenua, me ētahi atu tipu. I ngā tau tata nei, kua nui te aro ki ēnei nā ō rātou āhuatanga antioxidant, anti-inflammatory, me te neuroprotective.
Kua whakaatuhia he pānga pai ēnei matū ki te roro, tae atu ki te whakarei ake i te mahi hinengaro me te ārai i ngā mate neurodegenerative. Ko te 7,8-DHF tētahi o ngā matū polyphenolic rongonui e piki haere ana te aro ki a ia hei nootropic. Kua rangahauhia mō ōna pānga pea ki te wairua, te mahara, te ako, te manukanuka, me ētahi atu mahi hinengaro.
E whakaarohia ana ko ngā pānga io o te 7,8-DHF ka puta mai i tana taunekeneke me ngā kaiwhakawhiwhi motuhake. Kua kitea ko TrkA, he kaiwhakawhiwhi e whai wāhi ana ki te tohu ira tipu io, ā, he mea nui hoki mō te oranga me te kirihou o ngā io.
Ka mahi te 7,8-DHF mā te whakahaere i te whakaaturanga o ngā momo kaiwhakawhiwhi, tae atu ki ngā waeine kaiwhakawhiwhi glutamate me te BDNF. Ka pā hoki ki te hanganga synapse, te pākia o te pūngao, me te tukunga o te acetylcholine i ētahi wāhi o te roro.
Kua whānuitia ngā rangahau mō te 7,8-dihydroxyflavone ki ōna pānga ki te hauora o te tangata, me te tirotiro anō hoki me pēhea e whai ai i te mahi a te roro-i ahu mai i te neurotrophic factor (BDNF), he pūmua nui mō te oranga me te mahi a ngā neuron.
Mō ōna whakamahinga, kua tūhuratia te 7,8-DHF mō ngā tono pea i roto i te rongoā i ngā mate pūnaha io nā tōna kaha ki te uru atu ki te arai toto-roro.
Ka puta noa te 7,8-Dihydroxyflavone i roto i ngā momo kai tipu, tae atu ki:
●Ngā hua: āporo, hua rākau, karepe me ngā hua citrus
●Huawhenua: riki, kāreti, pūrokoro me te pīnihi
●Otaota: Pāhiri, taimi me te oregano
Haunga ēnei puna taiao, kei te wātea hoki te 7,8-DHF i roto i te ahua tāpiringa hei kai watea, hei kai whakamahere hoki.
Akohia ngā flavonoids
He pūhui polyphenolic ngā flavonoid e whai wāhi nui ana ki te whakaputa tae o ngā tipu, te tātari UV, me te ātete ki ngā mate. Kua wehea ēnei ki ētahi wāhanga iti, tae atu ki ngā flavonol, flavones, isoflavones, flavanones, me ngā anthocyanins. He rerekē ngā hanganga matū me ngā mahi koiora o ia wāhanga iti, ā, he rerekē ngā painga hauora.
He aha te 7,8-dihydroxyflavone?
Ko te 7,8-Dihydroxyflavone he momo flavonoid motuhake nō te akomanga flavonoid. E rua ngā rōpū hydroxyl o tōna hanganga matū kei ngā tūranga 7 me te 8 o te tuarā flavonoid, koinei te take o ōna āhuatanga ahurei. Ka kitea nuitia tēnei matū i roto i ngā tipu pēnei i te dioscorea (umu) ā, kua rangahauhia mō ōna pānga tiaki io, ōna āhuatanga ārai-mumura, me te whakarei ake i te hinengaro.
Ngā Rerekētanga Matua i waenga i te 7,8-DHF me ētahi atu Flavonoids
1. Hanganga matū
Ko te rerekētanga tino kitea i waenga i te 7,8-DHF me ētahi atu flavonoid ko tōna hanganga matū. Ahakoa he rite tonu te pūtake o te nuinga o ngā flavonoid, ka pā nui te noho o ngā rōpū hydroxyl i ngā tūranga motuhake ki tā rātou mahi koiora. Hei tauira, he rerekē te whakaritenga o ngā rōpū hydroxyl o te quercetin, he flavonol rongonui, e pā ana ki tōna wairewatanga me te taunekeneke ki ngā whāinga koiora.
2. Ngā mahi koiora
Kua whakaatuhia he mahi koiora ahurei tā te 7,8-DHF ki te whakataurite ki ētahi atu flavonoid. E whakaatu ana ngā rangahau ka whakahohehia e ia te ara tohu neurotrophic factor (BDNF) i ahu mai i te roro, he mea nui mō te oranga, te tipu me te rerekētanga o ngā neuron. He mea tino nui tēnei tikanga i roto i te horopaki o ngā mate neurodegenerative me te hekenga o te hinengaro.
He rerekē, ko ētahi atu flavonoids pērā i ngā catechins (e kitea ana i roto i te tī matomato) me ngā anthocyanins (e kitea ana i roto i ngā hua rākau) ka mahi matua mā te mahi antioxidant, te tango i ngā rauropi kore utu me te whakaiti i te ahotea oxidative. Ahakoa he pai ēnei āhuatanga, kāore pea e pā tika ki ngā āhuatanga neurotrophic pērā i te 7,8-DHF.
3. Te wātea o te koiora
Ko te wāteatanga koiora e pā ana ki te whānuitanga me te tere o te mimiti o tētahi matū hohe, o tētahi wāhanga hohe rānei, ā, ka wātea ki te wāhi mahi. Kua whakaatuhia e te 7,8-DHF he wāteatanga koiora pai i roto i ngā rangahau kararehe, e tohu ana ka taea e ia te whiti pai i te arai toto-roro, he mea nui mō ōna pānga tiaki io.
He rerekē, ka rerekē te wātea o ētahi atu flavonoids i roto i te tinana. Hei tauira, ahakoa e kainga whānuitia ana te quercetin, he iti noa te mimiti o te quercetin nā te tere o te pākia o te tinana. Ka pā tēnei rerekētanga o te wātea o te tinana ki te whai huatanga o ēnei matū ki te whakatutuki i ngā hua hauora e hiahiatia ana.
7,8-DHF tikanga mahi: Te whakahaere i te BDNF me te whakahohenga o te kaiwhakawhiwhi Trkb
Mō te tikanga mahi, e mōhiotia ana te 7,8-DHF hei whakatairanga i te whakaputanga o te BDNF (te take neurotrophic i ahu mai i te roro) mā te herea me te whakahohe i tana kaiwhakawhiwhi TrkB. Engari kaua e tino hangarau rawa, ka arahi tēnei ki tētahi raupapa o ngā mahi pūtau e whai hua ana ki te pupuri i te mahi tika o ngā neuron me te whakatairanga i te neurogenesis.
Te momo mahi matua a te 7,8-DHF:
(1) Te take neurotrophic i ahu mai i te roro (BDNF) me tōna tūranga i roto i te neuroplasticity
I te kitenga kua whakaitihia te whakaaturanga o te roro-i ahu mai i te neurotrophic factor (BDNF) i roto i ngā mate neurodegenerative, inā koa ko te mate a Alzheimer (AD), kei te kitea haere tōna hiranga ki te pupuri me te whakarei ake i te hauora o te roro.
He mea nui te BDNF mō ngā mahi neuronal maha, nā te mea ka whakatairanga i te tuku synaptic, te synaptogenesis, me te plasticity synaptic mā te tohu me ngā kaiwhakawhiwhi TrkB. Nā tēnei ka waiho te ara tohu BDNF-TrkB hei whāinga whai hua mō te whanaketanga o ngā wawaotanga rongoā e aro ana ki te whawhai ki ngā mate neurodegenerative.
(2) Ara tohu a te kaiwhakawhiwhi Tropomyosin kinase B (Trkb)
He mahi nui tā te kaiwhakawhiwhi tropomyosin receptor kinase B (TrkB) ki te whakahaere i ngā pānga o te BDNF ki ngā neuron. Hei kaiwhakawhiwhi tyrosine kinase transmembrane, ko TrkB te kaiwhakawhiwhi tuatahi mō te BDNF, ā, ka tīmata i te raupapa o ngā kaupapa tohu ā-roto i te wā e herea ana ki ngā āhuatanga neurotrophic.
Ka whakahohehia e te BDNF a TrkB hei whakaoho i ētahi ara matua o roto i te pūtau, tae atu ki te phosphatidylinositol 3-kinase (PI3K)-Akt, te mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK), me te ara phospholipase Cγ (PLCγ)-protein kinase C (PKC). Ka whai wāhi ia o ēnei ara ki tētahi āhuatanga rerekē o te mahi me te oranga o ngā io.
He mea nui te ara PI3K-Akt mō te whakatairanga i te oranga o ngā pūtau io me te aukati i te apoptosis. Ka whakahohehia e te tohu BDNF-TrkB tēnei ara hei whakanui ake i te oranga o ngā pūtau mā te aukati i ngā āhuatanga pro-apoptotic me te whakaoho i ngā āhuatanga anti-apoptotic, kia mau tonu ai te oranga o ngā pūtau io hauora.
I tētahi atu taha, he mahi nui tā te ara MAPK-ERK i roto i te rerekētanga me te tipu o ngā pūtau io. Mā te tohu BDNF-TrkB ka whakahohehia te ara MAPK-ERK, ā, mā tēnei ka tautoko i te pakeketanga me te rerekētanga o ngā pūtau io me tō rātou whakaurunga ki roto i ngā whatunga pūtau io o nāianei.
He mea nui te ara PLCγ-PKC mō te whakahaere i te kirihou o te hononga io, he tukanga taketake o te ako me te mahara. Ka whakarerekē te tohu BDNF-TrkB i te mahi o tēnei ara, ā, ka mutu, ka puta he panoni i te kaha me te hononga o te hononga io.
Ka whakatairangahia e tēnei whakarerekētanga te urutau me te whakaritenga anō o ngā ara iahiko io hei urupare ki ngā wheako hou me ngā whakaohooho taiao.
Mā te mahi hei kaiwhakaoho TrkB, ka puta ngā pānga nootropic a te 7,8-DHF mā te whakahaere i ngā ara tohu e pā ana ki te BDNF, ā, mā reira ka whakatairanga i te neurogenesis me te whakarei ake i te kirihou synaptic.
Mā te whai i ngā pānga o te BDNF, ka āwhina te 7,8-DHF ki te tiaki i ngā neurons mai i te kino, ka whakatairanga i tō rātou oranga, ā, ka whakatairanga i te tipu me te pupuri i ngā hononga neurons hou. Mā tēnei kaha ki te whakatairanga i te neuroplasticity, te whakapai ake i te mahi hinengaro, me te whakamamae i ngā tohu o ngā mate neurological ka waiho te 7,8-DHF hei kaitono whai hua mō te whakawhanaketanga rongoā me ngā rangahau atu.
Ngā Painga Nootropic 7,8-DHF: Te Whakarei Aromātai me te Tiakitanga Neuro
Mō ōna painga nootropic, e whā ngā tikanga matua e mahi ai te 7,8-DHF:
Te whakakotahi me te whakahoki mai i te mahara: he mahi e whakawhirinaki ana ki te hippocampus
Kua kitea te kaha o te 7,8-DHF ki te whakarei ake i te whakakotahitanga me te whakahoki mai i te mahara i roto i ngā momo mahi ako me te mahara e whakawhirinaki ana ki te hippocampus i roto i ngā tauira kiore. E kī ana ēnei kitenga he rongoā nootropic pai pea te 7,8-DHF, ka taea te whakamahi hei whakapai ake i te mahi mahara i roto i ngā tāngata hauora me te hunga he ngoikore te mahara.
Te kirihou hononga: te kaha me te pouri mo te wa roa
Kua whakaaturia te kaha o te 7,8-DHF ki te whakahaere i te kirihou o te synaptic mā te whakatairanga i te LTP me te whakaiti i te LTD i roto i te hippocampus. E whakaarohia ana ko ēnei pānga ka puta mai i tōna kaha ki te whakahohe i ngā kaiwhakawhiwhi TrkB, ā, muri iho ka whakarei ake i te ara tohu BDNF. Ka whai wāhi tēnei whakarerekētanga o te kirihou o te synaptic ki ngā whakapainga o te mahi hinengaro i kitea i muri i te whakahaerenga o te 7,8-DHF.
Ngā āhuatanga ārai mate: te tango ROS me te whakakōkī lipid
He āhuatanga ārai-mate kei te 7,8-DHF, e whakaatuhia ana e tōna kaha ki te kohikohi i ngā momo hāora tauhohe (ROS) me te whakaiti i te peroxidation lipid. Ka whai wāhi ēnei pānga ki ōna pānga tiaki-ira mā te whakaiti i te kino me te kore mahi o ngā neuron i puta mai i te ahotea oxidative.
Pānga ārai-mumura: whakahaere i te whakahohenga microglial me te whakaputa cytokine
Haunga ōna āhuatanga ārai-pūmua, kua kitea he pānga ārai-mumura te 7,8-DHF mā te whakarerekē i te whakahohenga o te microglial me te whakaiti i te hanga o ngā cytokine pro-inflammatory pērā i te TNF-α me te IL-1β. Ka whai wāhi atu tēnei ki ōna pānga tiaki-ira me te nootropic mā te ārai i te kino o ngā neuron e puta mai ana i te mumura.
Ina rapu ana koe i tētahi kaiwhakarato o7,8-DihydroxyflavonePaura, ka taea e koe te whakaaro ki ngā āhuatanga e whai ake nei:
1. Te ingoa pai o te kaiwhakarato
He mea nui te whiriwhiri i tētahi kaiwhakarato he ingoa pai tōna. Ka taea e koe te mōhio ki te ingoa o tētahi kaiwhakarato mā te tirotiro i ngā arotake a ngā kiritaki, ngā pūrongo ahumahi, me ngā huihuinga ngaio. He ingoa pai tō Suzhou Myland i roto i te ahumahi, me ngā urupare pai a ngā kiritaki me te kounga o ngā hua e mōhiotia whānuitia ana.
2. Te kounga o te hua
Me whakarite kia tutuki ngā hua e tukuna ana e ngā kaiwhakarato i ngā paerewa o te ao me ngā whakaritenga whakahaere kounga. Kua oti te whakamātautau kounga tino pakari o te Paura Suzhou Myland 7,8-Dihydroxyflavone, ā, he parakore tae atu ki te 98%, e whakarite ana i te whai huatanga me te haumaru o te hua.
3. Tiwhikete me te Whakatutukitanga
Mā te whiriwhiri i tētahi kaiwhakarato whai tiwhikete GMP (Good Manufacturing Practice) me te ISO ka tutuki i tā rātou tukanga whakaputa ngā paerewa o te ao. Ka tino whai a Suzhou Myland i ēnei paerewa hei whakarite i te pumau me te ōritetanga o ia puranga hua.
4. Tautoko hangarau me ngā ratonga
Me whakarato e te kaiwhakarato pono te tautoko hangarau ngaio me te ratonga kiritaki. He rōpū hangarau ngaio tō Suzhou Myland ka taea te tuku tohutohu whakamahinga hua me te aratohu hangarau ki ngā kiritaki hei āwhina i ngā kiritaki ki te whakatutuki i ngā hua pai ake i roto i te rangahau me te tono.
5. Te utu me te wā tuku
He mea nui anō hoki te whakaaro ki te utu me te wā tuku ina whiriwhiri ana i tētahi kaiwhakarato. Ka taea e koe te tono utu mai i ngā kaiwhakarato maha me te whakatairite i ā rātou utu me ngā wā tuku kia kitea ai te kōwhiringa tino tika. Suzhou Myland
e whakarato ana i ngā utu whakataetae me ngā wā tuku ngāwari me te whakarite i te kounga o te hua.
Me pēhea te tiki i te paura 7,8-Dihydroxyflavone
Mena kei te rapu koe i te Paura 7,8-Dihydroxyflavone kounga teitei, ko Suzhou Myland te whiringa pai māu. Ka taea e koe te whakapā mai mā te:
Paetukutuku mana: Tirohia tepaetukutuku mana o Suzhou Mylandki te ako atu mō ngā mōhiohio hua me te tautoko hangarau.
Kōrerorero tuihono: Kōrero tika ki tā mātou tīma ratonga kiritaki mā te mahi kōrerorero tuihono e whakaratohia ana e te paetukutuku hei tiki i ngā mōhiohio hua me ngā whakahua e hiahiatia ana e koe.
Waea whakapā: Waea mai ki tā mātou nama whakapā hei whakapā atu ki ngā kaimahi hokohoko ngaio, hei tiki atu i ngā kōrero taipitopito mō te hua me ngā whakaaro hoko.
Uiui īmēra: Ka taea hoki e koe te pātai mai mō ngā mōhiohio hua mā te īmēra, ā, ka whakautu atu mātou ki a koe i te wā e taea ai.
Ehara i te mea ngāwari te kimi i ngā kaiwhakarato Paura 7,8-Dihydroxyflavone pono, engari mā te aro ki te ingoa o te kaiwhakarato, te kounga o te hua, te tiwhikete me te tutuki i ngā whakaritenga, te tautoko hangarau me te ratonga, tae atu ki te utu me te wā tuku, ka taea e koe te whakatau whakaaro nui. whiriwhiria. Ko Suzhou Myland tō hoa pai me tana Paura 7,8-Dihydroxyflavone tino parakore me te ratonga kiritaki tino pai. Kei te tumanako mātou ki te mahi tahi me koe ki te tūhura i ngā pūmanawa tono atu o te 7,8-Dihydroxyflavone.
Q: Ka taea e te proflavin te whakapai ake i te kaha ako?
Āe, kua whakaaturia te kaha o te proflavin ki te ako mā te whakatairanga i te neurogenesis me ngā hononga synaptic. Ka whakahaere i ngā pūnaha neurotransmitter he mea nui ki te tukanga ako, inā koa i roto i te hippocampus, he rohe matua o te roro mō te ako.
Q: Ka āwhina te 7,8-DHF i te whakaoranga hinengaro i muri i te whara?
Āe, e kī ana ngā rangahau haumanu-mua ka āwhina pea te 7,8-DHF i te whakaora hinengaro i muri i te whara o te roro mā te whakatairanga i te tiaki io me te whakaora io. Ka whakaitihia te mate o ngā io me te tautoko i te tipu o ngā io hou, ka whakapai ake pea i te mahi hinengaro kua pakaru i te whara, i te whara ischemic rānei.
Q: He aha te mahi a te 7,8-dihydroxyflavone ki te hekenga o te hinengaro e pā ana ki te koroheketanga?
A:E kī ana ngā rangahau hou ka taea e te 7,8-DHF te whakaroa i te hekenga o te hinengaro e pā ana ki te koroheketanga mā te tiaki i a rātou mai i te ahotea waikura me te mumura, arā, ngā āhuatanga noa i roto i ngā mate hinengaro e pā ana ki te koroheketanga.
Mā te whakarei ake i ngā taumata BDNF me te whakahohenga o te kaiwhakawhiwhi TrkB, ka āwhina i te pupuri i te manawanui hinengaro, ahakoa me nui ake ngā rangahau tangata hei tūhura i ēnei pānga.
Q: Ka taea e te 7,8-DHF te whakapai ake i te aro me te mahi whakahaere?
A:E ai ki ngā rangahau tuatahi ki ngā kararehe, ka taea e te 7,8-DHF te whakapai ake i te aro me te mahi whakahaere mā te whakarei ake i te whakahaere o ngā neurotransmitter me ngā hononga io i roto i ngā rohe roro e whai wāhi ana ki ēnei tukanga.
Whakakape: He kōrero whānui noa iho tēnei tuhinga, kaua e whakamāramatia he tohutohu hauora. Ko ētahi o ngā kōrero o te pou rangitaki i ahu mai i te Ipurangi, ehara i te mea ngaio. Ko tā tēnei paetukutuku anake he whakarōpū, he whakatakotoranga me te whakatika i ngā tuhinga. Ko te kaupapa o te kawe atu i ētahi atu kōrero, ehara i te mea e whakaae ana koe ki ōna tirohanga, e whakaū ana rānei i te pono o ōna ihirangi. Me kōrero tonu ki tētahi tohunga hauora i mua i te whakamahi i tētahi tāpiringa, i te hanga rānei i ngā huringa ki tō tikanga tiaki hauora.
Wā tuku: Oketopa-16-2024
