Ngā rauemi mata haumaru mō te mitophagy me ngā kai hou mō te ārai-pakeketanga - Urolithin A

Te hītori ourolithin A (UA)ka taea te whai i ngā kōrero mai i te tau 2005. He matū whakaputa o ngā moroiti puku, ā, kāore e taea te tāpiri tika mā roto i ngā hongere kai. Heoi, he nui ngā hua pēnei i te pamekaranete me te rōpere kei roto i ōna mua ko ngā ellagitannin.

Te mahi a te urolithin A

I te 25 o Poutū-te-rangi, 2016, i roto i tētahi rangahau nui i roto i te maheni "Nature Medicine" i arohia ai te hunga whakarongo ki tōna hononga ki te whakaroa i te koroheketanga o te tangata. Mai i te kitenga i te tau 2016 ka taea e te UA te whakaroa i te roanga o te oranga o te C. elegans, kua whakamahia te UA i ngā taumata katoa (ngā pūtau take hematopoietic, te kiko kiri, te roro (ngā whekau), te pūnaha ārai mate, te roanga o te oranga takitahi) me ngā momo momo (C. elegans, melanogaster). Kua tino whakaatuhia ngā pānga ārai-pakeketanga i roto i ngā namu hua, ngā kiore, me te tangata.

(1) Te ārai i te koroheketanga me te whakarei ake i te mahi a te uaua
I whakaatuhia i roto i tētahi whakamātautau haumanu matapōkere i whakaputaina i roto i te JAMA Network Open, he hautaka apiti o te Journal of the American Medical Association, mō te hunga kaumātua, te hunga rānei e uaua ana ki te neke nā te mate, ka āwhina pea ngā tāpiringa UA ki te whakapai ake i te hauora o ngā uaua me te mahi i ngā mahi whakakori tinana e hiahiatia ana.

(2) Āwhina ki te whakapakari i te kaha ārai-pukupuku o te rongoā ārai mate
I te tau 2022, i kitea e te rōpū rangahau a Florian R. Greten o te Georg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics i Tiamana ka taea e te UA te whakaoho i te mitophagy i roto i ngā pūtau-T, te whakatairanga i te tukunga o te PGAM5, te whakahohe i te ara tohu Wnt, me te whakatairanga i te hanganga o ngā pūtau take mahara-T, ā, nā reira ka whakatairanga i te ārai mate ārai-pukupuku.

(3) Whakahoki i te koroheketanga o ngā pūtau take hematopoietic me te pūnaha ārai mate
I roto i tētahi rangahau i te tau 2023, i rangahau te Whare Wānanga o Lausanne i Switzerland i tōna pānga ki te pūnaha hematopoietic mā te tuku i ngā kiore 18-marama te pakeke ki te kai i ngā kai momona i te urolithin A mō ngā marama e 4, me te aroturuki i ngā huringa o ō rātou toto ia marama.
I whakaatuhia e ngā hua i piki ake te maha o ngā pūtau take hematopoietic me ngā pūtau tūpuna lymphoid i te kai UA, ā, i heke iho hoki te maha o ngā pūtau tūpuna erythroid. E kī ana tēnei kitenga ka taea e tēnei kai te whakakore i ētahi o ngā huringa o te pūnaha hematopoietic e pā ana ki te koroheketanga.

(4) Pānga ārai-mumura
He kaha ake te mahi ārai-mumura o te UA, ā, ka taea e ia te aukati i ngā momo āhuatanga mumura noa pēnei i te TNF-α. Nā konei tonu i whai wāhi ai te UA ki ngā maimoatanga mumura maha tae atu ki te roro, te ngako, te ngākau, te puku me ngā kiko ate. Ka taea e ia te whakaora i te mumura i roto i ngā kiko rerekē.

(5) Te Tiakitanga o te Niho
Kua whakaū ētahi tohunga ka taea e te UA te aukati i te ara apoptosis e pā ana ki te mitochondria me te whakahaere i te ara tohu p-38 MAPK, ā, ka aukati i te apoptosis i puta mai i te ahotea waikura. Hei tauira, ka taea e te UA te whakapai ake i te tere oranga o ngā neuron i whakaohokia e te ahotea waikura, ā, he pai hoki te mahi tiaki io.

(6) Te pānga o te ngako
Ka pā te UA ki te pākia o te ngako pūtau me te lipogenesis. Kua whakaatuhia e ngā rangahau ka taea e te UA te whakaoho i te whakahohenga o te ngako parauri me te parauri o te ngako mā, me te ārai i te kohikohinga ngako i puta mai i te kai.

(7) Whakapai ake i te momonatanga
Ka taea hoki e te UA te whakaiti i te kohikohinga o te ngako i roto i ngā pūtau ngako me ngā pūtau ate i whakatipuria i roto i te vitro, me te whakanui ake i te waikura ngako. Ka taea e ia te huri i te T4 iti ake te kaha i roto i te thyroxine ki te T3 kaha ake, ka whakarei ake i te tere o te pākia me te whakaputa wera mā te tohu thyroxine, ā, ka whai wāhi nui ki te whakahaere i te momonatanga.

(8) Tiakina ngā kanohi
Ka taea e te UA inducer mitophagy te whakaiti i te ahotea waikura i roto i te retina kua koroheke; ka whakaitihia te taumata o te cGAS cytosolic me te whakaiti i te whakahohenga o ngā pūtau glial i roto i te retina kua koroheke.

(9) Te tiaki kiri
I roto i ngā matū whakaputa whekau o ngā mammal katoa i kitea, ko te UA te mea tino kaha ki te ārai mate, tuarua ki ngā proanthocyanidin oligomers, catechins, epicatechin me te 3,4-dihydroxyphenylacetic acid. Taria.

Ngā horopaki tono Urolithin A

I te tau 2018, kua tohua te UA e te US Food and Drug Administration hei matū kai "e mōhiotia whānuitia ana he haumaru" ā, ka taea te tāpiri atu ki ngā inu pūmua, ngā inu whakakapinga kai, te ōti tere, ngā pae pūmua kai me ngā inu miraka (tae atu ki te 500 mg/tūnga)), te miraka kawa Kariki, te miraka kawa pūmua nui me ngā inu miraka kawa pūmua (tae atu ki te 1000 mg/tūnga).

Ka taea hoki te tāpiri i te UA ki ngā hua tiaki kiri, tae atu ki ngā kirīmi awatea, ngā kirīmi pō me ngā ranunga hinu, i hangaia hei whakarei ake i te makuku o te kiri me te whakaiti nui i ngā kita, hei whakapai ake i te kakano o te kiri mai i roto ki waho, me te whawhai whai hua ki ngā tohu o te koroheketanga, ā, hei āwhina i te kiri kia noho taitamariki.

Te tukanga whakaputa Urolithin A

(1) Te tukanga whakapūkara
Ko te whakaputanga arumoni o te UA ka tutuki tuatahi mā te hangarau whakapūkara, e whakapūkarahia ana mai i ngā kiri pamekaranete, ā, he nui ake i te 10% te nui o te urolithin A.
(2) Te tukanga hanga matū
I te mea kei te haere tonu te auahatanga me te whanaketanga o ngā rangahau, he huarahi nui te hanga matū mō te whakaputa ahumahi o te urolithin A. He kamupene tāpiringa pūtaiao koiora auaha a Suzhou Myland Pharm, he kamupene hanga ritenga me ngā ratonga hanga e taea ai te whakarato rauemi mata mō te paura urolithin A, he nui te rahinga, he tino parakore.