Ko te Salidroside te matū matua i tangohia mai i te Rhodiola rosea, ā, he maha ngā āhuatanga koiora me ngā āhuatanga rongoā. Ko ngā pānga o te Salidroside he ātete i te ahotea waikura, he aukati i te apoptosis pūtau, me te whakaiti i ngā tauhohenga mumura.
Salidroside he antioxidant tūturu e tiaki ana i ngā pūtau io mā te tango i te ROS me te aukati i te apoptosis pūtau.
Ko te nui rawa o te konupūmā i roto i te pūtau tētahi o ngā tino take o te apoptosis neuronal. Ka taea e te tangohanga Rhodiola rosea me te salidroside te whakaiti i te pikinga o ngā taumata konupūmā kore utu i roto i te pūtau i puta mai i te ahotea oxidative me te tiaki i ngā pūtau cortical tangata mai i te glutamate. Ka taea e te Salidroside te aukati i te whakahohenga microglial i puta mai i te lipopolysaccharide, te aukati i te hanga NO, te aukati i te mahi inducible nitric oxide synthase (iNOS), me te whakaiti i ngā taumata TNF-α me te IL-1β, IL-6.
Ka ārai a Salidroside i te NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) me te kaiwhakatikatika urupare mō te whanaketanga me te kino DNA 1 (REDD1)/mammalian target of rapamycin (mTOR)/p70 ribosome. Ka whakahohe te ara tohu pūmua S6 kinase i te AMP-dependent protein kinase/silent information regulator 1, te mema whānau ira ōrite RAS A/MAPK me ngā ara tohu PI3K/Akt.
1. Ka ārai a Salidroside i te kino o ngā rauropi kore utu, ā, ka tiaki i te tinana
Ka taea e te tinana te whakaputa i tētahi nui o ngā rauropi kore utu taketake i roto i ngā tukanga ā-tinana noa, ā, me whai i tētahi horopeta ā-tinana o ngā rauropi kore utu hei pupuri i ngā mahi ā-tinana noa o te tinana. He pūnaha whakakore rauropi kore utu anō hoki kei roto i te tinana hei tango i ngā rauropi kore utu e nui ake ana i ngā horopeta ā-tinana kia kore ai e kino ki te hauora o te tinana.
Heoi, i raro i te mana o ētahi āhuatanga taiao motuhake, ka nui rawa ngā rauropi kore utu o roto o te tinana, ka nui atu i te tere kohikohi rauropi kore utu o te pūnaha, ka puta he kore taurite i roto i te pūnaha whakaputa-kohikohi rauropi kore utu o te tinana, ka hua ake he kohikohinga o ngā rauropi kore utu o te hāora i roto i te tinana, ā, ka pakaru te kiriuhi pūtau.
E whakaatu ana ngā rangahau ka taea e te taiao hypoxic i raro i ngā āhuatanga plateau te whakararu i te taurite o te pākia o ngā rauropi kore-hāora, te kohikohi i ngā rauropi kore-pūnaha me te whakanui ake i ngā hua peroxidation lipid. Kua whakaatuhia e ngā rangahau ka taea e te salidroside te tiaki i ngā pūtau kiko mā te tango i ngā rauropi kore-hāora i roto i te tinana.
2. Salidroside Ka ārai i te hypoxia hei pupuri i te pumau o te mahi mitochondrial
E whakamahia ana te 80-90% o te hāora ā-roto mō te waikura koiora i roto i ngā mitochondria hei whakaputa ATP me te hanga i ngā momo hāora tauhohe ROS hei pupuri i ngā mahi noa o ngā pūtau. E 10-20% anake o te hāora e wātea ana i waho o ngā mitochondria mō te biosynthesis, te degradation, te biotransformation (detoxification), me ētahi atu. Ka whakarei ake te mahi manawa o ngā mitochondria i te wā hypoxia ngawari, i te wā tōmua rānei o te hypoxia, e whakaatuhia ana hei urupare utu o te pūnaha manawa o te tinana.
Ka pāngia tuatahitia te hāora o waho o ngā mitochondria e te hypoxia nui me ngā mate pākia o te tinana, ka whakaiti i te hanga o ngā neurotransmitters, ka ngoikore hoki ngā āheinga biotransformation, ā, ka pāngia ngā mahi a ngā kiko me ngā okana. Kua whakaatuhia e ngā rangahau ka taea e te salidroside te tiaki i te pupuri i te mahi mitochondria mā te whakaiti i te ihirangi ROS i roto i ngā mitochondria pūtau, te whakanui ake i te mahi SOD, me te whakanui ake i te maha o ngā mitochondria.
3. Te pānga tiaki o te salidroside ki te uaua ngākau
Kua whakaatuhia e ngā rangahau ko te pūnaha manawa te pūnaha matua e whakarerekē ana i te taiao koretake. Ka ngoikore te pākia o te tinana e te taiao koretake, ā, ka kore e ranea te tuku pūngao, ka puta ai ngā tohu pēnei i te koretake o te hāora, te ischemia, me te apoptosis o ngā pūtau uaua ngākau. Kua whakaatuhia e ngā rangahau ka taea e te salidroside te whakarei ake i te mahi o te ngākau me te whakapai ake i te tohanga toto iti mā te whakawhānui i ngā oko toto uaua me te uaua, te whakapai ake i te rere o te toto uaua ngākau, te whakarerekē i te hemodynamics o te ngākau, te whakaiti i te kawenga o te ngākau, me te whakaiti i te kino o te ischemic uaua ngākau.
I roto i te poto, ka taea e te salidroside te mahi ki te pūnaha manawa mā roto i ngā tikanga maha, ngā ara, me ngā whāinga, te tiaki i te apoptosis o ngā pūtau uaua ngākau i puta mai i ngā take maha, me te whakapai ake i ngā āhuatanga ischemia me te hypoxia o te tinana. I roto i te taiao hypoxia, he mea nui te wawaotanga a Rhodiola rosea ki te tiaki i ngā kiko me ngā okana o te tinana me te pupuri i te pumau o ngā mahi pūtau. He mahi nui tāna ki te ārai me te whakaiti i te mate teitei.
Te āhua o nāianei o te hanga salidroside
1) Te nuinga o te whakawhirinaki ki te tango tipu
Ko te Rhodiola rosea te rauemi mata osalidroside.Hei momo tipu otaota ā-tau, ka tupu te Rhodiola rosea i ngā wāhi e tino makariri ana, e kore e mate, e maroke ana, ā, he nui te rerekētanga o te pāmahana i waenganui i te ao me te pō i te teitei o te 1600-4000 mita. Ko tētahi o ngā tipu papatairite mohoao. Ko Haina tētahi o ngā wāhi whakaputa matua o te Rhodiola rosea i te ao, engari he tino motuhake ngā tikanga noho o te Rhodiola rosea. Ehara i te mea he uaua ki te whakatipu hangai anake, engari he tino iti te hua o ngā momo mohoao. Ko te āputa tono ā-tau mō te Rhodiola rosea e eke ana ki te 2,200 tana.
2) Te hanga matū me te whakapūtanga koiora
Nā te iti o te ihirangi me te nui o te utu whakaputa i roto i ngā tipu, haunga ngā tikanga tango taiao, kei roto hoki i ngā tikanga whakaputa salidroside ngā tikanga hanga matū, ngā tikanga whakapūkara koiora, me ētahi atu. I roto i ēnei, i te haere tonu o te whanaketanga o te hangarau, kua noho te whakapūkara koiora hei huarahi hangarau matua mō te whanaketanga rangahau me te whakaputanga o te salidroside. I tēnei wā, kua tutuki i a Suzhou Mailun ngā hua rangahau me te whanaketanga, ā, kua tutuki hoki te ahumahi.
Whakakape: He kōrero whānui noa iho tēnei tuhinga, kaua e whakamāramatia he tohutohu hauora. Ko ētahi o ngā kōrero o te pou rangitaki i ahu mai i te Ipurangi, ehara i te mea ngaio. Ko tā tēnei paetukutuku anake he whakarōpū, he whakatakotoranga me te whakatika i ngā tuhinga. Ko te kaupapa o te kawe atu i ētahi atu kōrero, ehara i te mea e whakaae ana koe ki ōna tirohanga, e whakaū ana rānei i te pono o ōna ihirangi. Me kōrero tonu ki tētahi tohunga hauora i mua i te whakamahi i tētahi tāpiringa, i te hanga rānei i ngā huringa ki tō tikanga tiaki hauora.
Wā tuku: 15 o Ākuhata-2024
