He tukanga taiao te autophagy i roto i ō tātou pūtau e mahi ana hei kaitiaki hei tiaki i tō tātou hauora mā te wawahi i ngā wāhanga pūtau tawhito, kua pakaru, me te hangarua anō i aua wāhanga hei pūngao. He mea nui tēnei tikanga horoi-ake ki te pupuri i te hauora pai, te ārai i ngā mate me te whakaroa i te oranga. He waimarie, he maha ngā huarahi ka taea e tātou te whakarei ake me te whakaoho i te autophagy kia pai ai te mahi a ō tātou pūtau.
Ko te kupu autophagy, i ahu mai i ngā kupu Kariki "auto" ko te tikanga "whaiaro" me "phagy" ko te tikanga kai, e pā ana ki te tukanga pūtau taketake e āhei ai ngā pūtau ki te whakangaro me te hangarua i ō rātou ake wāhanga. Ka taea te kī he tikanga horoi-whaiaro e whai wāhi nui ana ki te pupuri i te hauora pūtau me te homeostasis.
I roto i ō tātou tinana, e miriona ngā pūtau e whai ana i te autophagy tonu hei tango i ngā pūmua kua pakaru, kua he rānei te takai, ngā whekau kore mahi me ētahi atu para pūtau. Ka āwhina tēnei tukanga ki te aukati i te kohikohinga o ngā matū paitini, ā, ka taea te hangarua anō i ngā macromolecules, kia pai ai te mahi a te pūtau.
tikanga mahi
AutophagyKa whakahaerehia mā roto i tētahi raupapa o ngā mahi tino uaua, ā, he tino kaha te whakahaere. Ka tīmata te tukanga mā te hanganga o ngā hanganga kiriuhi-rua e kiia nei ko ngā autophagosome, e horomia ai ngā wāhanga ūnga i roto i ngā pūtau. Kātahi ka honoa te autophagosome ki te lysosome, he whekau motuhake kei roto ngā momo whākōkī, ka arahi ki te pakaru o ngā mea kei roto.
E toru ngā momo matua o te autophagy: te macroautophagy, te microautophagy, me te chaperone-mediated autophagy. Ko te macroautophagy ko te whakangaromanga nui o ngā wāhanga pūtau, ko te microautophagy ia ko te horomitanga tika o ngā rauemi cytoplasmic e ngā lysosomes. I tētahi atu taha, ko te chaperone-mediated autophagy ka aro motuhake ki ngā pūmua kia whakangaromia.
Te Whakahau me te Tohu
He maha ngā ara tohu e whakahaeretia ana te autophagy hei whakautu ki ngā momo taumahatanga pūtau, pērā i te korenga o ngā matūkai, te ahotea waikura, te mate me te kohikohinga pūmua. Ko tētahi o ngā kaiwhakahaere matua o te autophagy ko te ūnga mammalian o te rapamycin (mTOR), he pūmua kinase e aukati ana i te autophagy ina nui ngā matūkai. Heoi, i raro i ngā āhuatanga o te whakawhāititanga matūkai, ka aukatihia te tohu mTOR, ka arahi ki te whakahohenga autophagy.
1. Te nohopuku ā-wā:
Mā te whakawhāiti i te matapihi whāngai, ka noho te tinana i roto i te āhua nohopuku roa i te nohopuku ā-wā, ka akiaki i ngā pūtau ki te whakamahi i te pūngao kua rongoatia me te tīmata i te autophagy.
2. Whakakorikori tinana:
Ehara i te mea ka ora noa te tinana i te wā e whakakorikori tinana ana, engari he mea kaha hoki hei whakaoho i te autophagy. Mā te whai wāhi atu ki ngā mahi whakakorikori tinana ā-hauora me te ātete ka whakaoho i te autophagy, ka whakatairanga i te horoi me te whakaora i te taumata pūtau.
3. Te herenga karori:
Haunga te nohopuku ā-wā, ko te whakawhāiti i te kaha o te kai (CR) tētahi atu tikanga kua whakamātauhia hei whakarei ake i te autophagy. Mā te whakaiti i te kai katoa o te kaha, ka akiakihia e te CR ō pūtau ki te tiaki i te pūngao me te tīmata i te autophagy hei pupuri i ngā mahi nui.
4. Kai Ketogenic:
Ka whakarei ake i te ngohe autophagic mā te whakaoho i te ketosis mā te whakawhāiti rawa i te kai warowaihā me te whakanui ake i te kai ngako.
5. Ngā kai whai rawa i ngā matū tipu:
Ko ētahi matū tipu, inā koa ko ērā e kitea ana i roto i ngā hua, huawhenua me ngā mea kakara tae kanapa, he āhuatanga kei a rātou e whakaoho ana i te autophagy.
6. Tangohia ngā tāpiringa motuhake:
Ka taea te whakaoho i te autophagy mā te tāpiri i ngā tāpiringa autophagy ki te kai hei whakatairanga i te hauora.
1. Tī matomato
He nui ngā matū ārai mate pērā i ngā catechin, kua roa te mōhiotia o te tī matomato mō ōna painga hauora. Haunga tōna kaha ki te whakanui ake i te pākia o te tinana me te tautoko i te whakaheke taumaha, kua whakaatuhia hoki te āheinga o te tī matomato ki te whakahohe i te autophagy. Ko ngā polyphenols e kitea ana i roto i te tī matomato ka whakaoho i te whakaaturanga o ngā ira e whai wāhi ana ki te autophagy, e āwhina ana ki te pupuri i te taurite me te mahi a ngā pūtau.
2. Tākare
Ko te curcumin, te matū hohe i roto i te turmeric me tōna tae kōwhai kanapa, he kaha ki te ārai i te mumura me te ārai mate. Kua whakaatuhia e ngā rangahau hou ka taea hoki e te curcumin te whakaoho i te autophagy mā te whakahohe i ētahi ara ngota. Mā te whakauru i te turmeric ki roto i tō kai, ahakoa mā te tunu kai, mā te tāpiringa rānei, ka āwhina i te whakamahi i te kaha o te autophagy ki te whakapai ake i te hauora.
3. Pēperina
I kitea i roto i tētahi rangahau e arotake ana i te berberine, tera pea ka taea e tēnei matū te whakaoho i te autophagy. Kei roto i ngā hua rākau, i te turmeric o te rākau, me ētahi atu otaota te berberine.
4. Ngā hua
Ehara i te mea he reka noa iho ngā hua pēnei i te purūpere, te rōpere, me te rāhipere, engari he maha hoki ngā āhuatanga hauora. He nui ngā polyphenols i roto i ēnei hua oraora, arā, ngā matū e mōhiotia ana hei whakarei ake i te autophagy. Mā te kai i ngā momo hua hou, hua tio rānei, ka taea e koe te whakarite kia mau tonu te tuku o ēnei matū tipu whai hua e tautoko ana i tētahi tukanga autophagy pakari me te whai hua.
5. Huawhenua ripeka
Kei roto i ngā huawhenua cruciferous, tae atu ki te broccoli, te cauliflower, te kale me te Brussels sprouts, he maha ngā matūkai e whakatairanga ana i te hauora, pērā i te sulforaphane me te indole-3-carbinol. Kua whakaatuhia e ēnei matūkai ka whakahohe i te autophagy me te ārai i te kino o ngā pūtau i puta mai i te ahotea oxidative. Ko te whakaurunga o ngā momo huawhenua cruciferous ki te kai ehara i te mea ka whakarato noa i ngā matūkai nui engari ka whakatairanga hoki i te whakaoho o te autophagy.
1. Kurkumini
Kua roa te rongonui o te curcumin, te matū hohe i roto i te turmeric, mō ōna āhuatanga ārai-mumura me te antioxidant. Kua whakaatuhia hoki e ngā rangahau tata nei ka taea e te curcumin te whakaoho i te autophagy, e whakapai ake ana i te hauora o te pūtau. Ka whakahohehia e te curcumin ngā ira motuhake me ngā ara tohu e uru ana ki te whakahaere i te autophagy. Ko tōna kaha ki te whakarei ake i te autophagy ka whai hua pea ki ngā mate maha e pā ana ki te ahotea oxidative me te ngoikore o te pūtau.
2. Pēperina
He matū taiao te Berberine e kitea ana i roto i ngā momo tipu, tae atu ki te barberry me te goldenseal. Kua rangahaua whānuitia tēnei tāpiringa tipu kaha mō ōna pānga rongoā ki ngā momo āhuatanga, tae atu ki ngā mate pākia. I kitea hoki ka whakaoho te Berberine i te autophagy mā te whakarerekē i te whakaaturanga o ngā ira e pā ana ki te autophagy. Mā te tāpiri atu ki te berberine, ka taea e koe te whakarei ake i te autophagy me te whakapai ake i te hauora pūtau, inā koa ka tae mai ki te hauora pākia.
3. Spermidine
Ko te Spermidine (spermidine) he matū rauropi iti kei roto i ngā pūtau. Kua kitea e ngā rangahau he hononga tata kei waenganui i te spermidine me te autophagy. Ka taea e te Spermidine te whakahohe i te ara autophagy me te whakatairanga i te autophagy. Kua whakaatuhia e ngā rangahau ka taea e te spermidine te whakanui ake i te whakaaturanga o ngā ira e pā ana ki te autophagy me te whakatairanga i te autophagy mā te whakahaere i ngā taumata o ngā pūmua e pā ana ki te autophagy. Hei tāpiri, ka taea hoki e te spermidine te whakahohe i te autophagy mā te aukati i te ara tohu mTOR.
Whakakape: Hei whakamōhiotanga anake tēnei tuhinga, kaua e kiia he tohutohu hauora. Me kōrero tonu ki tētahi tohunga hauora i mua i te whakamahi i tētahi tāpiringa, i te whakarerekē rānei i tō tikanga hauora.
Wā tuku: Hepetema-01-2023
