He aha ngā momo tikanga hanga parāoa? He aha ngā kai matua?

Spermidine He polyamine nui tēnei e kitea whānuitia ana i roto i ngā rauropi, ā, e whai wāhi ana ki ngā tukanga koiora maha pērā i te tipu pūtau, te rerekētanga me te apoptosis. He maha ngā momo tikanga hanga parāoa: te hanga koiora, te hanga matū me te hanga whākōkī. He painga me he ngoikoretanga motuhake tō ia tikanga, me ngā āhuatanga tono.

Ko te hanga koiora te ara matua mō te hanga parāoa, e mahia ana i roto i te raupapa o ngā tauhohenga whākōkī i roto i ngā pūtau. Ko te hanga koiora o te parāoa e whakawhirinaki ana ki te pākia o ngā waikawa amino, inā koa ko te lysine me te arginine. Tuatahi, ka hurihia te lysine hei waikawa aminobutyric (Putrescine) e te lysine decarboxylase, kātahi ka honoa te waikawa aminobutyric ki ngā waikawa amino i raro i te mahi a te spermine synthase hei hanga i te parāoa. Hei tāpiri, ko te hanga parāoa e uru ana hoki ki te pākia o ētahi atu polyamines, pērā i te putrescine (Cadaverine) me te spermine (Spermine). Ko ngā huringa o te kukū o ēnei polyamines i roto i ngā pūtau ka pā ki te hanga parāoa.

Ko te hanga matū he tikanga e whakamahia whānuitia ana mō te hanga parāmine i roto i te taiwhanga. Ko ngā matū waro māmā ka hurihia hei parāmine mā roto i ngā tauhohenga matū. Ko ngā huarahi hanga matū noa ka tīmata mai i ngā waikawa amino, ā, ka mutu ka whiwhi i te parāmine mā roto i te raupapa o ngā tauhohenga esterification, whakaiti me te amination. Ko te painga o tēnei tikanga ka taea te whakahaere i raro i ngā āhuatanga whakahaeretia, he teitei te parakore o te hua, ā, he pai mō ngā rangahau taiwhanga iti. Heoi, ko te hanga matū me whakamahi i ngā whakarewa waro me ngā whakakorikori, ka pā pea ēnei ki te taiao.

Ko te hanga whākōkī he tikanga hanga hou i whakawhanakehia i ngā tau tata nei, e whakamahi ana i tētahi tauhohenga whākōkī motuhake hei hanga i te parāmine. Ko ngā painga o tēnei tikanga ko ngā āhuatanga tauhohenga ngāwari, te whiriwhiringa teitei, me te atawhai taiao. Mā te hangarau hangarau ira, ka taea te whiwhi i te hanga pārāmine whai hua, ā, ka whakapai ake i te whai huatanga o te hanga. He whānui ngā huarahi tono o te hanga whākōkī i roto i te whakaputanga ahumahi, inā koa i roto i ngā mara o te rongoā koiora me ngā tāpiringa kai.

Ko ngā wāhanga matua o te parāmine ko ngā pūhui polyamine, tae atu ki te parāmine, te putrescine me te triamine. Kei roto i te hanganga ngota o te parāmine he maha ngā rōpū amino me te imino, ā, he kaha te mahi koiora. Kua whakaatuhia e ngā rangahau he mahi nui tā te parāmine ki te whakatipu pūtau, te ārai-waikura, me te ārai-pakeketanga. I ngā tau tata nei, kua kitea e te maha o ngā rangahau he hononga tata anō hoki tā te parāmine ki te putanga mai me te whanaketanga o ngā mate maha, pērā i te mate pukupuku, te mate manawa, me ngā mate neurodegenerative. Nō reira, kua aro nui te katoa ki te hanga me te whakamahi i te parāmine.

I roto i ngā mahi whaihua, ka taea te whakamahi i te parāoa hei matū mō te rangahau koiora anake, engari hei tāpiringa kai me te whakauru ki ngā hua hauora. I te mea ka aro nui te tangata ki te hauora, ka piki haere te hiahia o te mākete mō te parāoa. Mā te arotau i te tikanga hanga parāoa, ka taea te whakanui ake i tōna hua me te parakore, ā, ka taea hoki te whakaiti i te utu whakaputa, ā, ka whakatairanga i tōna whakamahinga i roto i ngā momo mara.

Ko te tikanga whānui, ko ngā tikanga hanga parāoa ko te hanga koiora, te hanga matū me te hanga whākōkī. He painga motuhake tō ia tikanga me ngā āhuatanga e tika ana. Ka taea e ngā rangahau ā muri ake nei te arotahi ki te whakapai ake i te whai huatanga o te hanga, te whakaiti i te pānga ki te taiao me te whakawhānui ake i ngā wāhi tono. Mā te whanaketanga tonu o te pūtaiao me te hangarau, ka puta mai ngā whai wāhitanga whanaketanga hou i te hanga me te tono o te parāoa.