He aha te 7,8-Dihydroxyflavone, ā, he aha koe me aro nui ai?

7,8-Dihydroxyflavone (7,8-DHF)He flavonoid tūturu te 7,8-Dihydroxyflavone, he matū polyphenolic e kitea ana i roto i ngā momo tipu. E mōhiotia ana ngā flavonoid mō ō rātou āhuatanga antioxidant, ā, he mahi nui tā rātou i roto i ngā tikanga tiaki tipu. Ko te 7,8-Dihydroxyflavone e kitea nuitia ana i roto i ngā tipu pērā i te Godmania aesculifolia me te Tridax procumbens.

He rerekē te 7,8-Dihydroxyflavone i ētahi atu flavonoids i tōna kaha ki te whai i te mahi a te roro-i ahu mai i te neurotrophic factor (BDNF). He pūmua te BDNF e tautoko ana i te oranga, te whanaketanga, me te mahi a ngā neurons i roto i te roro. He mahi nui tāna i roto i te neuroplasticity, arā, te kaha o te roro ki te whakarite anō i a ia anō mā te hanga hononga neural hou. Mā tēnei āhuatanga o te 7,8-DHF ka huaki ngā huarahi maha mō te rangahau, inā koa i roto i te mara o te neuroscience.

Tikanga mahi

Ko te tikanga matua e whakamahia ana e te 7,8-Dihydroxyflavone ko te whakahohenga o te kaiwhakawhiwhi TrkB (tropomyosin receptor kinase B). He kaiwhakawhiwhi hononga-teitei a TrkB mō te BDNF. Ina herea te 7,8-Dihydroxyflavone ki a TrkB, ka whakaohohia he raupapa ara tohu ā-roto e whakatairanga ana i te oranga o ngā neuron, te tipu, me te rerekētanga.

Kua whakaatuhia e ngā rangahau haumanu-mua ka taea e te 7,8-dihydroxyflavone te whai i te BDNF (te take neurotrophic i ahu mai i te roro) me te whakanui ake i tōna whakaaturanga me ōna taumata i roto i te hippocampus. I roto i ngā tauira kararehe, he kaha tōna ki te rongoā mō ētahi mate pūnaha io, arā, te whiu, te pouri, me te mate a Parkinson. I roto i ngā rangahau e rua, kua whakaatuhia e te 7,8-dihydroxyflavone te nui o te bioavailability ā-waha, ā, kua kitea kua whiti i te arai toto-roro (BBB). Nā te mea ka mahi i runga i te ara tohu hauota hauota me te whakahohe i te kaiwhakawhiwhi TrkB (tropomyosin receptor kinase B).

Ko te neurotrophic factor BDNF te nuinga o te wā e tuku ana i ngā tohu mā te herea ki ngā kaiwhakawhiwhi motuhake, ā, ka pā ki ngā tukanga ā-tinana o ngā neurons. Ahakoa ka taea e te 7,8-DHF te whakatauira i te pānga o te neurotrophic factor BDNF, ko te mea nui kei roto i tana tikanga taunekeneke me te kaiwhakawhiwhi BDNF. Kua whakaatuhia e ngā rangahau ka taea e te 7,8-DHF te herea ki te kaiwhakawhiwhi BDNF TrkB me te whakahohe i ngā ara tohu o raro.

Ina koa, ina herea te 7,8-DHF ki te TrkB, ka whakaohohia he raupapa o ngā kaupapa whakawhiti tohu ā-roto. Kei roto i tēnei ko te whakahohenga o ngā kinase pūmua pērā i ngā ara PI3K/Akt me MAPK/ERK. He mea nui te whakahohenga o ēnei ara mō te whakatairanga i te oranga o ngā neuron, te tipu, me te kirihou synaptic. Mā te whakatauira i te whakahohenga o ēnei ara e te BDNF, ka āwhina te 7,8-DHF ki te whakarei ake i te urutau neuron me te ātete ki te ahotea o waho.

Ka whakahaere anō hoki te 7,8-DHF i te whakaaturanga ira i roto i ngā neuron. Ka pā pea ki te tuhi ira e pā ana ki te whanaketanga o te roro, te tiaki i te roro me te hanganga synapse, ā, ka whai i ngā pānga o te BDNF i te taumata ngota. Ka tautokohia anō hoki e tēnei whakarerekētanga o te whakaaturanga ira te mahi a te 7,8-DHF ki te whakatairanga i te hauora o te roro.

Ko te 7,8-Dihydroxyflavone (7,8-DHF) he flavonoid monophenolic me ngā pānga maha. He agonist tēnei mō te neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) ā, ka tiaki i ngā neuron e whakaatu ana i te TrkB mai i te apoptosis. Ko te brain-derived neurotrophic factor (BDNF) he pūmua me ngā pānga neurotrophic e tino hira ana mō te hanganga roro, te ako me te mahara.

• Tiaki i te roro: He tiaki i te roro te 7,8-DHF i roto i ngā tauira kararehe o te mate a Parkinson, e tautoko ana i te ako kare ā-roto i roto i ngā kiore, ā, e whakakore ana i ngā hapa mahara i roto i ngā tauira kiore o te mate a Alzheimer, ā, ka taea hoki e ia te whakapai ake i te mahi nekeneke me te whakaroa i te wā oranga o ngā tauira kararehe mate. Ka taea e te BDNF te whakapai ake i te neuroplasticity me te oranga o ngā neuron, te āwhina i te roro ki te whakaputa hononga neural hou, te whakatika i ngā pūtau roro e ngoikore ana, me te tiaki i ngā pūtau roro hauora. He mea nui mō te hanganga roro, te ako me te mahara, ā, ka taea te tiaki i te roro mai i te ngoikore o te hinengaro e pā ana ki te koroheketanga. Ka heke te kaha hinengaro me te tiaki i ngā mate neurodegenerative pēnei i te mate a Alzheimer me te mate a Parkinson.

• Whakahaere i te oranga tonutanga o ngā pūtau io: Ka taea e te 7,8-DHF te here ki a TrkB me te whakahohe i ngā ara tohu o raro, pērā i ngā ara PI3K/Akt me MAPK/ERK. He mea nui te whakahohenga o ēnei ara hei whakatairanga i te oranga tonutanga o ngā pūtau io, te tipu me te kirihou synaptic. he mea nui. Ko te BDNF he āhuatanga neurotrophic hoki ka taea te whakahohe i ngā ara tohu ā-roto mā te here ki ngā kaiwhakawhiwhi TrkB me te whakatairanga i te oranga tonutanga me te tipu o ngā pūtau io.

• Whakatairanga i te kirihou o te hononga: Ka taea e te 7,8-DHF te whakatairanga i te hanganga me te whakapakari i ngā hononga mā te whakahohe i ngā kaiwhakawhiwhi TrkB, ā, ka whakapai ake i te whai huatanga o te tuku hononga. E whakaarohia ana hoki ka whakatairanga te BDNF i te hanganga me te whakapakari i ngā hononga, ā, ka whakanui ake i te whai huatanga o te tuku hononga, ā, ka whakarei ake i ngā pūkenga ako me te mahara.

• Ngā pānga ki te ako me te mahara: Ka taea e te 7,8-DHF te whakapai ake i ngā pūkenga ako me te mahara i roto i ngā kiore, e pā ana pea ki ōna pānga ki te oranga o ngā neuron me te kirihou o te synaptic. He mahi nui anō hoki tā te BDNF i roto i ngā tukanga ako me te mahara mā te whakatairanga i te oranga o ngā neuron me te hanganga o ngā synapses, ā, ka whakapai ake i ngā pūkenga ako me te mahara.

• Whakarerekē i te wairua: He pānga whakarerekētanga wairua tō te 7,8-DHF, e pā ana pea ki ōna pānga ki te oranga o ngā neuron me te kirihou o te synaptic. E whakaarohia ana hoki he wāhi nui tā te BDNF ki te whakahaere i ngā kare ā-roto mā te whakahaere i te oranga o ngā neuron me te hanganga o ngā synapses, ā, ka pā ki te whakaaturanga o ngā kare ā-roto.

Hei whakarāpopototanga, he rite tonu ngā tikanga mahi a te 7,8-DHF me te BDNF ki te tiaki i te pūnaha io, e whakahaere ana i te oranga tonutanga o ngā pūtau io, e whakatairanga ana i te kirihou o te synaptic, e pā ana ki te ako me te mahara, me te whakahaere i ngā kare ā-roto.

He kaihanga kua rēhitatia ki te FDA a Suzhou Myland Pharm & Nutrition Inc. e whakarato ana i te 7,8-Dihydroxyflavone kounga teitei, parakore hoki.

I Suzhou Myland Pharm, e whakapau kaha ana mātou ki te whakarato i ngā hua kounga teitei rawa atu i ngā utu pai rawa atu. Kua whakamatautauria rawatia te parakore me te kaha o tā mātou 7,8-Dihydroxyflavone, kia whiwhi ai koe i tētahi tāpiringa kounga teitei ka taea e koe te whakawhirinaki. Ahakoa e hiahia ana koe ki te tautoko i te hauora pūtau, ki te whakapakari i tō pūnaha ārai mate, ki te whakarei ake rānei i te hauora whānui, ko tā mātou 7,8-Dihydroxyflavone te whiringa tino pai.

Me te 30 tau o te wheako, me te mea hoki e ārahihia ana e te hangarau matatau me ngā rautaki R&D kua tino arotauhia, kua whakawhanakehia e Suzhou Myland Pharm he whānuitanga o ngā hua whakataetae, ā, kua riro hei kamupene auaha mō ngā tāpiringa pūtaiao koiora, te hanga ritenga me ngā ratonga hanga.

Hei tāpiritanga, he kaihanga kua rēhitatia ki te FDA a Suzhou Myland Pharm. He hou, he maha ngā mahi a ngā rauemi R&D a te kamupene, ngā whare whakaputa, me ngā taputapu tātari, ā, ka taea te whakaputa matū mai i te mirikaramu ki te tana i te tauine, me te tutuki i ngā paerewa ISO 9001 me ngā whakaritenga whakaputa GMP.