I te ao hauora e tipu haere tonu ana, kua noho ko te NAD+ hei kupu rongonui, e kukume ana i te aro o ngā kaipūtaiao me ngā kaiwhaiwhai hauora. Engari he aha tonu te NAD+? He aha te hiranga o tēnei mea ki tō hauora? Me ako atu tātou mō ngā mōhiohio e tika ana i raro nei!
He aha te NAD+?
Ko te ingoa pūtaiao o te NAD ko te nicotinamide adenine dinucleotide. Kei roto i ngā pūtau katoa o tō tātou tinana te NAD+. He matū matū me te coenzyme matua i roto i ngā momo ara pākia. Ka takawaenga, ka whai wāhi hoki ki ngā momo tukanga koiora. Neke atu i te 300 ngā whākōkī e whakawhirinaki ana ki te NAD+ hei mahi.
NAD+Ko te kupu "Nicotinamide adenine dinucleotide" te whakarāpopototanga reo Pākehā. Ko tōna ingoa katoa i te reo Hainamana ko te nicotinamide adenine dinucleotide, ko te "Coenzyme I" rānei. Hei "coenzyme" e tuku ana i ngā katote hauwai, he mahi nui tā NAD+ i roto i ngā āhuatanga maha o te pākia o te tangata, tae atu ki te glycolysis, te Gluconeogenesis, te huringa waikawa tricarboxylic, me ētahi atu. Kua tohua e ētahi rangahau ko te whakahekenga o te NAD+ e pā ana ki te pakeketanga, ā, ko ngā tikanga ā-tinana e whakahaerehia ana e te NAD+ e pā ana ki te koroheketanga, ngā mate pākia, te neuropathy me te mate pukupuku, tae atu ki te whakahaere i te homeostasis pūtau, ngā sirtuins e mōhiotia ana ko "ngā ira roa", te whakatika i te DNA, ngā pūmua whānau PARP e pā ana ki te necroptosis me te CD38 e āwhina ana i te tohu konupūmā.
He rite te mahi a NAD+ ki te pahi whakawhiti, e kawe ana i ngā irahiko mai i tētahi ngota pūtau ki tētahi atu. I te taha o tōna hoa ngota ngota NADH, ka whai wāhi atu ia ki ngā tauhohenga pākia maha mā te whakawhiti irahiko e whakaputa ana i te adenosine triphosphate (ATP), te ngota "pūngao" o te tinana.
Ki te kī māmā noa, he mea nui te NAD+ mō te pupuri i te hauora me te taurite o te tinana. Ko te pākia o te tinana, te redox, te tiaki me te whakatikatika i te DNA, te pumau o te ira, te whakahaere epigenetic, me ētahi atu mea katoa e hiahiatia ana te whai wāhi mai o te NAD+.
Nō reira, he nui te hiahia o te tinana mō te NAD+. Ka hangaia tonutia, ka wahia, ka hangaruatia hoki te NAD+ i roto i ngā pūtau hei pupuri i ngā taumata NAD+ pumau i roto i ngā pūtau.
He wāhanga nui te NAD+ o te mahi a te pūtau, ā, e whai wāhi ana ki te tuku pūngao me te whakatika i te DNA, e pā tata ana ēnei ki te koroheketanga hauora.
1) Ka horapa whānuitia i roto i ngā pūtau katoa o te tinana tangata, ā, ka whai wāhi atu ki ngā mano tini o ngā tauhohenga koiora-whakakorikori. Ka taea e ia te whakatairanga i te pākia o te huka, te ngako me ngā waikawa amino, me te whai wāhi atu ki te hanga pūngao. He coenzyme nui e tika ana mō te tinana tangata.
2) Ko NAD+ anake te matūriki mō ngā whākōkī e kai ana i te coI (koinei anake te matūriki mō te whākōkī whakatika DNA PARP, koinei anake te matūriki mō te pūmua roa o te ora Sirtuins, me te matūriki anake mō te ADP ribose synthase cyclic CD38/157).
Heoi, i te pikinga ake o te pakeketanga, ka tere te heke o te taumata o te NAD+ i roto i te tinana. Ka heke iho mā te 50% i ia 20 tau. I te tata ki te 40 tau te pakeke, ko te nui o te NAD+ i roto i te tinana tangata he 25% noa iho i tōna taumata i roto i ngā tamariki.
Ki te kore he NAD+ i roto i ngā pūtau tangata, ka heke te ngoikore o te mitochondrial, ka heke te kaha ki te whakatika i ngā pakaru o te DNA, ā, ka whakakorengia hoki te whānau pūmua ira roa o te ora, arā, ko te Sirtuin. Ka taea e ēnei āhuatanga kino te arahi ki te apoptosis, te mate tangata, te koroheketanga, tae noa ki te mate.
Te Tūranga o NAD+ i roto i tō Hauora Whānui
Ārai-pakeketanga
Mā te NAD+ e pupuri te whakawhitiwhiti matū i waenga i te karihi me ngā mitochondria, ā, ko te ngoikore o te whakawhitiwhiti he tino take o te koroheketanga o ngā pūtau.
Ka taea e te NAD+ te tango i te maha o ngā waehere DNA hē e piki haere ana i te wā e pākia ana e te pūtau, te pupuri i te whakaaturanga noa o ngā ira, te pupuri i te mahi noa o ngā pūtau, me te whakaroa i te koroheketanga o ngā pūtau tangata.
Whakatikahia te kino o te DNA
He matū nui te NAD+ mō te whākōkī whakatika DNA PARP, he pānga nui tōna ki te whakatika DNA, te whakaaturanga ira, te whanaketanga pūtau, te oranga pūtau, te hanga anō i ngā ira, me te pumau o te ira.
Whakahohehia te pūmua roa
E kiia ana ngā sirtuin ko te whānau pūmua roa te ora, ā, he mahi nui tā rātou ki te whakahaere i ngā mahi pūtau, pērā i te mumura, te tipu pūtau, te manawataki circadian, te pākia o te pūngao, te mahi neuronal, me te ātete ki te ahotea, ā, he whākōkī nui te NAD+ mō te hanganga o ngā pūmua roa te ora.
Ka whakahohe i ngā pūmua roa e whitu i roto i te tinana tangata, ka whai wāhi nui ki te ātete ki te ahotea pūtau, te pākia o te pūngao, te aukati i te whakarerekētanga pūtau, te apoptosis me te koroheketanga.
Whakaratohia te pūngao
Ka whakateretere i te whakaputanga o te neke atu i te 95% o te pūngao e hiahiatia ana mō ngā mahi ora. Ko ngā mitochondria i roto i ngā pūtau tangata ngā tipu hiko o ngā pūtau. Ko te NAD+ he coenzyme nui i roto i ngā mitochondria hei whakaputa i te ngota pūngao ATP, hei huri i ngā matūkai hei pūngao e hiahiatia ana e te tinana tangata.
Whakatairanga i te whakahoutanga o ngā oko toto me te pupuri i te ngāwari o ngā oko toto
He kiko tino nui ngā uaua toto mō ngā mahi o te ao. I a tātou e pakeke haere ana, ka memeha haere te ngāwari o ngā uaua toto, ka pakeke haere, ka matotoru haere, ka whaiti haere, ka puta te "arteriosclerosis".
Ka taea e te NAD+ te whakanui ake i te mahi a te elastin i roto i ngā oko toto, kia mau tonu ai te ngāwari o ngā oko toto me te hauora o ngā oko toto.
Whakatairanga i te pākia o te tinana
Ko te pākia o te tinana te huinga o ngā tauhohenga matū maha i roto i te tinana. Ka haere tonu te tinana ki te whakawhitiwhiti i ngā mea me te pūngao. Ina mutu tēnei whakawhitiwhitinga, ka mutu anō hoki te ora o te tinana.
I kitea e Ahorangi Anthony me tana tīma rangahau i Te Whare Wānanga o California, USA, ka taea e te NAD+ te whakapai ake i te puhoi o te pākia o ngā pūtau e pā ana ki te koroheketanga, ā, ka whakapai ake i te hauora o te tangata me te whakaroa i te roanga o te ora.
Tiakina te hauora o te ngākau
Ko te ngākau te okana tino nui o te tangata, ā, he mea nui te taumata NAD+ i roto i te tinana ki te pupuri i te mahi noa o te ngākau.
Tērā pea he hononga tō te whakahekenga o te NAD+ ki te pathogenesis o ngā mate pūnaha toto maha, ā, he maha ngā rangahau taketake kua whakaū i te pānga o te tāpiringa NAD+ ki ngā mate ngakau.
Ārai i ngā mate o te pūnaha cardiovascular me te roro
Kua whakaatuhia e ngā rangahau e pā ana te nuinga o ngā momo sirtuin e whitu (SIRT1-SIRT7) ki te putanga mai o te mate manawa. E kiia ana ko ngā sirtuin he whāinga agonistic mō te rongoā i ngā mate manawa, inā koa ko te SIRT1.
Ko NAD+ anake te matū mō ngā Sirtuin. Mā te tāpiri i te NAD+ ki te tinana tangata i te wā tika ka taea te whakahohe i te mahi a ia momo Sirtuin, ā, mā reira ka tiakina te hauora o te ngākau me te ārai i ngā mate ngākau.
Whakatairanga i te tipu o te makawe
Ko te tino take o te ngaronga o te makawe ko te ngaronga o te kaha o ngā pūtau whaea o te makawe, ā, ko te ngaronga o te kaha o ngā pūtau whaea o te makawe nā te mea ka heke te taumata NAD+ i roto i te tinana tangata. Kāore i te nui te ATP o ngā pūtau whaea o te makawe hei mahi i te hanga pūmua makawe, ā, ka ngaro tō rātou kaha, ka arahi atu ki te ngaronga o te makawe.
Nō reira, mā te tāpiri i te NAD+ ka taea te whakapakari i te huringa waikawa me te whakaputa ATP, kia nui ai te kaha o ngā pūtau whaea o te makawe ki te whakaputa pūmua makawe, ā, ka pai ake te ngaro o te makawe.
Kei hea te hoko i te tāpiringa Beta-NAD+ i runga ipurangi me te haumaru
He kaihanga kua rēhitatia ki te FDA a Suzhou Myland Pharm & Nutrition Inc. e whakarato ana i te paura tāpiringa NAD+ kounga teitei, parakore hoki.
I Suzhou Myland Pharm, e whakapau kaha ana mātou ki te whakarato i ngā hua kounga teitei rawa atu i ngā utu pai rawa atu. Kua whakamatautauria rawatia te parakore me te kaha o tā mātou paura NAD+ Tāpiringa, kia whiwhi ai koe i tētahi tāpiringa kounga teitei ka taea e koe te whakawhirinaki. Ahakoa e hiahia ana koe ki te tautoko i te hauora pūtau, ki te whakapakari i tō pūnaha ārai mate, ki te whakarei ake rānei i te hauora whānui, ko tā mātou paura NAD+ Tāpiringa te whiringa tino pai.
Me te 30 tau o te wheako, me te mea hoki e ārahihia ana e te hangarau matatau me ngā rautaki R&D kua tino arotauhia, kua whakawhanakehia e Suzhou Myland Pharm he whānuitanga o ngā hua whakataetae, ā, kua riro hei kamupene auaha mō ngā tāpiringa pūtaiao koiora, te hanga ritenga me ngā ratonga hanga.
Hei tāpiritanga, he kaihanga kua rēhitatia ki te FDA a Suzhou Myland Pharm. He hou, he maha ngā mahi a ngā rauemi R&D a te kamupene, ngā whare whakaputa, me ngā taputapu tātari, ā, ka taea te whakaputa matū mai i te mirikaramu ki te tana i te tauine, me te tutuki i ngā paerewa ISO 9001 me ngā whakaritenga whakaputa GMP.
Whakakape: He kōrero whānui noa iho tēnei tuhinga, kaua e whakamāramatia he tohutohu hauora. Ko ētahi o ngā kōrero o te pou rangitaki i ahu mai i te Ipurangi, ehara i te mea ngaio. Ko tā tēnei paetukutuku anake he whakarōpū, he whakatakotoranga me te whakatika i ngā tuhinga. Ko te kaupapa o te kawe atu i ētahi atu kōrero, ehara i te mea e whakaae ana koe ki ōna tirohanga, e whakaū ana rānei i te pono o ōna ihirangi. Me kōrero tonu ki tētahi tohunga hauora i mua i te whakamahi i tētahi tāpiringa, i te hanga rānei i ngā huringa ki tō tikanga tiaki hauora.
Wā tuku: Hepetema-19-2024
