He aha te spermidine? He aratohu māmā ki te spermidine

SpermidineHe momo polyamine. He iti, he momona, he polycationic (-NH3+) ngā polyamine. E whā ngā polyamine matua i roto i ngā kararehe whakangote: te spermine, te spermidine, te putrescine me te cadaverine. Nō ngā tetramine te spermine, nō ngā triamine te spermidine, nō ngā diamine te putrescine me te cadaverine. He rerekē ngā āhuatanga ā-tinana o ngā rōpū amino nā te maha rerekē o ngā rōpū amino.

Te Spermidine i roto i te tangata

Ehara i te mea kei roto noa i te purapura te spermidine, engari kei te horapa whānuitia hoki i roto i ētahi atu kiko me ngā pūtau o te tinana tangata. Ko te kukū o te spermidine i roto i te tinana e whakawhirinaki ana ki ngā āhuatanga e whā:

①Te hanganga ā-roto o te pūtau:

Arginine → putrescine → spermidine ← spermine. Ko te arginine te rauemi matua mō te hanga spermidine i roto i ngā pūtau. Ka whakakorikoria e te arginase hei whakaputa i te ornithine me te urea. Kātahi ka whakamahia te ornithine hei whakaputa i te putrescine i raro i te mahi a te ornithine decarboxylase (ODC1). Koinei te taahiraa whakawhāiti tere), ka whakaputa te putrescine i te spermidine i raro i te mahi a te spermidine synthase (SPDS). Ka taea hoki te whakaputa i te spermidine mā te whakahoro i te spermine.

②Te tangohanga o waho o te pūtau:

Kua wehea ki te kai e kainga ana me te hanga huakita puku. Ko ngā kai he nui te spermidine ko te witi, te natto, te pīni soya, te harore, me ētahi atu. Ko te spermine me te spermidine e kainga ana mai i te kai ka tere te mimiti mai i ngā puku, ā, ka tohatohahia me te kore e pirau, nō reira he tino kanorau te kukū o te spermidine i roto i te toto. Ka taea hoki e ngā huakita probiotic i roto i ngā huakita puku pēnei i te Bifidobacterium te hanga spermidine.

③Te Whakakorikoritanga:

Ka āta pirau haere te parāoa i roto i te tinana hei spermidine me te putrescine mā te N1-acetyltransferase (SSAT), te polyamine oxidase (PAO) me ētahi atu amine oxidase, ko te putrescine ia ka hurihia hei waikawa aminobutyric mā ngā oxidase. Hei whakamutunga, ka puta ngā katote amine me te hauhā waro mai i te tinana, ā, ka tukuna atu.

④Tau:

Ka rerekē te kukū o te spermidine i te pakeketanga. I inehia e ngā kairangahau te kukū o ngā polyamine i roto i ngā kiko me ngā whekau rerekē o ngā kiore 3-wiki te pakeke, 10-wiki te pakeke me te 26-wiki te pakeke, ā, i kitea e rātou kei te noho tonu i roto i te repeure, te roro me te kōpū. Ka iti haere ngā huringa o te whekau i te pakeketanga, ā, ka tino heke haere i roto i te thymus, te whēkau, te ovary, te ate, te puku, te pukahukahu, te whatukuhu, te ngākau me te uaua. Ehara i te mea uaua ki a tātou te whakapae ko ngā take mō tēnei huringa ko ngā huringa kai, ngā huringa o te hanganga o ngā tipu whekau, te whakaiti i te mahi a te polyamine synthase, me ētahi atu.

Te ūnga tūturu o te spermidine

He aha te take he matū matua nui tēnei ngota iti māmā mō te tinana tangata? Ko te mea ngaro kei roto i tōna hanganga: Ko te Spermidine he ngota iti polycationic (-NH3+) fatty amine e noho ana i roto i te āhua maha-protonated i raro i ngā āhuatanga pH ā-tinana, me ngā katote pai e horapa ana puta noa i te mekameka waro. He kaha te mahi ā-tinana o te hiko.

Nō reira, ahakoa he waikawa karihi, he phospholipids, he pūmua waikawa kei roto ngā toenga waikawa, he polysaccharides pectic kei roto ngā rōpū carboxyl me ngā sulfates, he neurotransmitters me ngā homoni (dopamine, epinephrine, serotonin, homoni tairoi, me ētahi atu) he rite ngā hanganga, tera pea he ūnga mō te here spermidine. Ko ngā mea tino nui ko:

① Waikawa karihi:

Kua kitea e ngā rangahau ko te nuinga o ngā polyamine kei roto i te āhua o ngā matatini polyamine-RNA i roto i ngā pūtau, me te 1-4 ngā ōrite o te polyamine e herea ana mō ia 100 ōrite o ngā matū phosphate. Nō reira, ko te mahi matua a te spermidine e pā ana ki ngā huringa hanganga me te whakamaoritanga o te RNA, pērā i te pānga ki ngā wāhanga rerekē o te hanganga pūmua mā te pānga ki te hanganga tuarua o te mRNA, te tRNA me te rRNA. Ka taea hoki e te spermidine te hanga "piriti" pumau i waenga i ngā whenu DNA takirua-porowhita, e whakaiti ana i te urunga atu o ngā rauropi kore utu, ētahi atu kaihoko kino DNA rānei, me te tiaki i te DNA mai i te denaturation wera me te hihi X-ray.

②Pūmua:

Ka taea e te Spermidine te here ki ngā pūmua e mau ana i ngā utu kino nui, ā, ka huri i te āhua ā-wāhi o te pūmua, ka pā ki tana mahi ā-tinana. Ko ētahi tauira ko ngā protein kinases/phosphatases (he hononga nui i roto i ngā ara whakawhiti tohu maha), ngā whākōkī e whai wāhi ana ki te histone methylation me te acetylation (e pā ana ki te whakaaturanga ira mā te huri i te epigenetics), acetylcholinesterase (he wāhanga nui o ngā mate neurodegenerative), tētahi o ngā rongoā whakaora), ngā kaiwhakawhiwhi hongere katote (pēnei i te AMPA, ngā kaiwhakawhiwhi AMDA), me ētahi atu.

He kaihanga kua rēhitatia ki te FDA a Suzhou Myland, e whakarato ana i te paura Spermidine kounga teitei, parakore hoki.

I Suzhou Myland, e whakapau kaha ana mātou ki te whakarato i ngā hua kounga pai rawa atu i ngā utu pai rawa atu. Kua whakamatautauria rawatia te parakore me te kaha o tā mātou paura Spermidine, kia whiwhi ai koe i tētahi tāpiringa kounga teitei ka taea e koe te whakawhirinaki. Ahakoa e hiahia ana koe ki te tautoko i te hauora pūtau, ki te whakapakari i tō pūnaha ārai mate, ki te whakarei ake rānei i te hauora whānui, ko tā mātou paura Spermidine te whiringa tino pai.

Me te 30 tau o te wheako, ā, e akiakihia ana e te hangarau matatau me te rautaki R&D tino arotau, kua whakawhanakehia e Spermidine he whānuitanga o ngā hua whakataetae hei kamupene auaha mō ngā tāpiringa pūtaiao koiora, te hanga ritenga me ngā ratonga hanga.

Hei tāpiritanga, he kaihanga kua rēhitatia ki te FDA a Suzhou Myland. He hou, he maha ngā mahi a ngā rauemi R&D a te kamupene, ngā whare whakaputa, me ngā taputapu tātari, ā, ka taea te whakaputa matū mai i te mirikaramu ki te tana i te tauine, ā, e tutuki ana hoki i ngā paerewa ISO 9001 me ngā whakaritenga whakaputa GMP.