He aha te telomerase activator-cycloastraganol kua kitea i tēnei wā?

I te tau 1985, i kitea tuatahitia e Greider me ētahi atu te telomerase, ā, ka taea e tēnei whākōkī hou te tāpiri i ngā tāruarua DNA ki ngā pito o ngā chromosomes hei pupuri i te roa o te telomere. Ko te Telomerase he matatini ribonucleoprotein kei roto i tōna pūtake whakakorikori ko te TERT me te TERC, ko te TERT te mea matua ki te whakahaere i te mahi telomerase. Ka poto tonu te roa o te telomere i te wā e wehea ana ngā pūtau. Ina tae ki tētahi uara nui, ka puta he tohu kino o te DNA, ka hua ake he huringa pūtau poto me te raupapa o ngā mate ngoikore kiko e tohuhia ana e ngā telomere poto.

I te tau 2010, i mahi tahi te kamupene Amerikana a Geron me te Whare Wānanga o te Pūtaiao me te Hangarau o Hong Kong i runga i tētahi kaupapa rangahau hei tirotiro i ngā kaiwhakaoho telomerase. I kitea kocycloastraganolKa taea te whakahohe i te mahi telomerase me te whakaoho i te toronga telomere. Nā tēnei kitenga i whakatairanga te whanaketanga o ngā kaiwhakaoho telomerase. Te ahunga whakamua o te rangahau me te whanaketanga hua e pā ana ki te waipiro astragalus. Ko te Cycloastragenol (CAG) anake te kaiwhakaoho telomerase kua pūrongohia i roto i ngā hua taiao. Ka taea e ia te whawhai pai ki te whakapoto o te telomere, ā, he ārai-pakeketanga, he ārai-apoptosis, he ārai-fibrosis, he whakahaere ārai mate, he whakatairanga i te tipu pūtau me te whakaora patunga, me ētahi atu. Ngā pānga rongoā, nā reira he pānga rongoā pea ki ngā mate e pā ana ki te ngoikore o te telomere.

Cycloastragenol me te koroheketanga

ngā telomere
He hanganga motuhake ngā telomere kei ngā pito o ngā ira-kōromōhio e tiaki ana i ngā ira-kōromōhio, ā, ka whakapotohia mā te whakaputanga ira-kōromōhio me te wehenga pūtau. Ka pakeke haere hoki ngā pūtau i te whakapototanga o ngā telomere.

telomerase
Ka taea e te telomerase te hanga telomere hei whakau i te roa me te hanganga o ngā telomere, ā, mā reira ka tiakina ngā chromosomes me te whakaroa i te koroheketanga o ngā pūtau.

Ārai-pakeketanga: He whakahohe telomerase, e whai pānga ārai-pakeketanga mā te whakanui ake i te telomerase, ā, mā reira ka whakaroa i te whakapoto o ngā telomere.

Ko ngā telomere he taupoki kei ngā pito o ngā ira pūtau e tiaki ana i a rātou mai i te kino i te wā e wehea ana te pūtau. I a ngā pūtau e wehea tonu ana, ka poto haere tonu ngā telomere, ka tae ki tētahi wāhi nui ka koroheke, ka mate rānei ngā pūtau. Ka taea e te telomerase te whakaroa i te roa o ngā telomere, ā, ka piki ake te roa o te ora o ngā pūtau.

He wāhanga kore e taea te karo i te koroheketanga o te ao; heoi, kei te rangahau ngā kairangahau i ngā momo maimoatanga hei karo i ētahi o ngā pānga o te koroheketanga, tae atu ki te ako i ngā senolytics. Ko ngā senolytics he matū e whakakore ana i ngā pūtau tawhito (pakeketanga) ā, kua whakaaturia ka whakaiti i ngā pānga o te koroheketanga. E kī ana tētahi rangahau hou he pānga ārai-pakeketanga tō te cycloastraganol.

Ko te rangahau, nō Haina, ā, i whakaputaina ki te International Journal of Molecular Sciences, i arotahi ki ngā pūtau tangata kua koroheke me ngā kiore kua koroheke nā te hihi. Ka whakaitihia e te cycloastragenol ngā pūtau kua koroheke me te kore e pā ki ngā pūtau kāore i koroheke. Ka whakaitihia hoki e te maimoatanga cycloastragenol ngā pūmua i roto i ngā pūtau kua koroheke e hiahiatia ana mō te tipu me te oranga o ngā pūtau. Hei tāpiri, ka aukati i ngā nekehanga pūtau e pā ana ki ngā pūtau mumura me ngā tukanga e pā ana ki te koroheketanga. I kitea he iti ake ngā pūtau kua koroheke i roto i ngā kiore kua koroheketia i rongoatia ki te cycloastraganol, ā, kua pai ake te ngoikore o te tinana e pā ana ki te koroheketanga.

Ka whakaitihia e te Cycloastragenol ngā pūtau kua koroheke

He tohu rongonui te koroheketanga o te tinana, engari kua kitea e ngā kairangahau ko te whakakore i ngā pūtau koroheketanga me ā rātou ngota tohu mumura ka āwhina i te ārai i ngā mate e pā ana ki te koroheketanga, ā, ka taea hoki te whakakore i aua mate i ētahi wā. I konei, i rongoatia e ngā kairangahau ngā pūtau tangata ki te cycloastraganol, ā, i kitea he pai te whakakore i ngā pūtau koroheketanga me te kore e pā ki ngā pūtau kāore i koroheke. Hei tāpiri, i tino heke ngā tohu pūtau o ngā pūtau koroheketanga i muri i te maimoatanga cycloastraganol.

Kua whakaatuhia e ngā rangahau o mua ko te ara PI3K/AKT/mTOR—he ara tohu e uru ana ki te tipu me te oranga o te pūtau—e uru ana ki ngā tukanga mumura i tīmatahia e ngā pūtau kua koroheke, e āwhina ana ki te whakatairanga i te koroheketanga i roto i ngā pūtau e karapoti ana. I kitea e ngā kairangahau i āwhina te cycloastragenol ki te whakaiti i ngā pūmua i roto i tēnei ara, e kī ana ka mahi pea te matū mā te aukati i te ara PI3K/AKT/mTOR hei āwhina i te aukati i te koroheketanga. I tua atu, kua whakaaturia te cycloastragenol ki te whakaiti i te kaha o ngā pūtau kua koroheke ki te whakatairanga i te koroheketanga mā te tukunga o ngā ngota mumura, ngā āhuatanga tipu, me ngā immunomodulators, e rite ana ki ngā whakaaro ko te whakaiti i te tohu PI3K, AKT, me te mTOR ka taea te whakaiti i ngā pānga whakatairanga-keketanga i waenga i ngā pūtau e karapoti ana.

Nō roto i ngā saponin triterpene te Cycloastragenol, ā, ka riro mai i te waikura o te astragaloside IV. He iti noa te taumaha ngota, ā, he kaha te lipophilicity, he mea whai hua ki te urunga biofilm me te mimiti o te puku kia pai ake ai te wātea o te koiora. Te whai huatanga o te cycloastragalinol
1. Te rongoā i te pakaru o te roro
2. Whakapai ake i te fibrosis ate
3. Te rongoā mō te osteoporosis
4. Pānga ārai-pakeketanga
5. Whakaroa i te koroheketanga o ngā pūtau

He aha te take e tika ai te hanga i te cycloastraganol?

① He maha ngā pānga rongoā o te Cycloastraganol pēnei i te aukati i te apoptosis pūtau roro me te neuroinflammation i te wā o te ischemia roro me te pupuri i te arai toto-roro.
② Ko te Cycloastragenol anake te matū terpenoid ngota iti anake e whai mahi telomerase ana kua kitea tae noa mai ki tēnei wā, ā, ka taea te rongoā i ngā mate neurodegenerative.
③ He pānga tōna ki te aukati i te fibrosis myocardial me te whakapakari i te ārai mate pukupuku. He ngota rongonui i roto i te rangahau me te whakawhanaketanga o ngā rongoā ārai-pakeke.

Ngā raruraru o nāianei

He tino iti te ihirangi o te cycloastraganol i roto i te Astragalus membranaceus, ā, he uaua ki te tiki tika. Ko te rautaki whakaputa cycloastraganol o nāianei e whakawhirinaki ana ki te tango rongoā tuku iho Hainamana, e whiwhihia ana mā te huri i te astragaloside IV i roto i te Astragalus membranaceus. Arā, ka whiwhihia te astragaloside IV mā te hangarau whakato astragalus me te ahurea kiko, kātahi ka hurihia te astragaloside IV hei cycloastragaloside mā te whakamahi i te acidolysis, te Smith degradation, te enzyme me te microbial hydrolysis. Heoi, he utu nui ēnei tikanga whakarite, he ngāwari ki te whakapoke i te taiao, he uaua ki te wehe me te pure, ā, kāore e pai mō te tono me te whakatairanga. Nō reira, kua tahuri te iwi ki te hanga horihori o te cycloastraganol.

Me pēhea te whakamahi i te koiora hangai hei hanga? ---Koiora Hangai

Ko te Koiora Hanga e pā ana ki te hoahoa whai take, te whakarerekētanga, tae noa ki te waihanga i te "ora hangai" me ngā mahi tauhou i raro i te arataki a ngā ariā hangarau, arā, te hangarau o te koiora. I te nuinga o te wā, ka hangaia mā te whakamahi i ngā tikanga koiora.