Ngā mea e tika ana kia mōhio koe mō te koroheketanga me ngā tikanga ka taea e koe te mahi hei whakaroa i tōna tere

I te kaumātuatanga o te tangata, he tokomaha e rapu huarahi ana hei whakaroa i te tukanga, hei pupuri i te āhua taitamariki me te ora. He maha ngā rautaki me ngā tikanga ka taea te whakamahi hei āwhina i te whakaroa i te tukanga koroheketanga me te whakatairanga i te hauora me te oranga whānui.

E whakaatu ana ngā rangahau hou ehara i te mea ka puta mārire noa te koroheketanga, engari ka puta hoki i tētahi wā motuhake i waenga i te 44 me te 60 tau.

Mai i te tīmatanga o ō tau 40, ka rerekē te pākia o tō ngako me tō waipiro, ā, ka tīmata te heke o te mahi a tō whatukuhu, te pākia o te warowaihā, me te whakahaere i te pūnaha ārai mate i te 60 tau. I kite anō ngā kairangahau i ngā huringa nui o te kiri, ngā uaua me te mōrearea o te mate ngakau i waenga i te 40 me te 60 tau te pakeke.

I whakaurua ki te rangahau te 108 noa iho o ngā tāngata o California i waenga i te 25 ki te 75 tau te pakeke, ā, me nui ake ngā rangahau hei whakaū i ngā kitenga. Heoi anō, mā ēnei kitenga ka arahi pea ki ngā whakamātautau tātaritanga hou me ngā rautaki hei ārai i ngā mate e pā ana ki te koroheketanga.

Kāore te roa o te ora e tohu ana i te ora hauora, i te ora kaha rānei o te kaumātuatanga. E ai ki te kaituhi matua o te rangahau, a Tākuta Michael Snyder, te kaiwhakahaere o te Center for Genomics and Personalized Medicine i Te Whare Wānanga o Stanford, mō te nuinga o te tangata, ko te roanga o te "ora hauora" toharite - te wā e noho ora pai ana rātou - he roa ake i te poto o te roanga o te ora 11-15 tau.

He mea nui te waenganui-o-te-oranga mō te koroheketanga hauora

Kua whakaatuhia e ngā rangahau o mua he mea nui te hauora o te tangata i waenganui o te ora (i waenganui i te 40 me te 65 tau te pakeke) ki tō hauora i muri mai. I honoa e tētahi rangahau i te tau 2018 i roto i te puka Nutrition ngā āhuatanga motuhake o te noho i waenganui o te ora, pērā i te taumaha hauora, te kaha tinana, te kai i te kai pai me te kore e momi hikareti, ki te hauora pai ake i te wā e koroheke ana.

I whakaatuhia anō hoki i roto i tētahi pūrongo i whakaputaina i roto i te puka 2020, ko te wā waenga-ora he wā whakawhiti nui mō te hauora o te roro. Mā te whakahaere i te toto toto me te noho kaha ki te taha pāpori, te hinengaro me te tinana i tēnei wā o te ao ka āwhina i te whakaiti i te mōrearea o te mate wareware i muri mai i te ao, e ai ki te pūrongo.

E whai wāhi atu ana tēnei rangahau hou ki te mara o te rangahau hauora, e whakaatu ana hoki i te hiranga o te whakawhanake i ētahi whanonga noho i te tīmatanga o te ao.

"Ko te hauora o koe i te 60, 70, 80 rānei ō tau, e whakawhirinaki ana ki ngā mahi i mahia e koe i ngā tekau tau i mua atu i a koe," te kī a Kenneth Boockvar, MD, kaiwhakahaere o te Center for Integrated Research on Aging i te Whare Wānanga o Alabama i Birmingham, engari kāore i uru ki te rangahau.

I kī atu ia he wawe rawa ki te whakatakoto i ngā taunakitanga motuhake i runga i ngā rangahau hou, engari ko te hunga e hiahia ana kia noho hauora i roto i ō rātou tau 60 me tīmata ki te aro ki ā rātou kai me te momo noho i roto i ō rātou tau 40 me 50.

Kāore e taea te karo i te koroheketanga, engari ka taea e ngā huringa āhua noho te whakaroa i te roanga o te oranga hauora

E kitea ana i roto i ngā rangahau hou ka heke te maha o ngā ngota me ngā moroiti e pā ana ki te koroheketanga i ngā wāhanga motuhake o te huringa ora, engari me whai rangahau ā muri ake nei hei whakatau mēnā ka puta ngā huringa ngota ōrite i roto i ngā taupori rerekē.

"E hiahia ana mātou ki te tātari i te tini o ngā tāngata puta noa i te motu kia kite ai mēnā e pā ana ā mātou kitenga ki te katoa — kaua ko te hunga o te rohe o te kokoru anake," te kī a Snyder. "E hiahia ana mātou ki te tātari i ngā rerekētanga i waenga i ngā tāne me ngā wāhine. Ka roa ake te ora o ngā wāhine, ā, e hiahia ana mātou ki te mārama he aha."

Kāore e taea te karo i te koroheketanga, engari mā ētahi huringa āhua noho ka āwhina i te whakaiti i te mōrearea o ngā mate e pā ana ki te koroheketanga. Heoi anō, he maha atu ngā āhuatanga pēnei i te taiao, te pumau pūtea, te tiaki hauora me ngā whai wāhitanga mātauranga ka pā ki ngā putanga koroheketanga hauora, ā, he uaua ki te tangata te whakahaere.

Ka taea e te tangata te whakarerekē i ngā momo noho pēnei i te inu wai hei pupuri i te hauora o te whatukuhu, te hanga uaua mā te whakangungu taumaha me te tango rongoā cholesterol mēnā he teitei te cholesterol LDL, e ai ki tā Snyder.

I tāpiri atu ia: "E kore pea tēnei e aukati i te koroheketanga, engari ka whakaitihia ngā raruraru e kitea ana e tātou, ā, ka āwhina i te whakaroa i te roanga o te oranga hauora o te tangata."

He aha ngā mea ka taea te mahi hei whakaroa i te koroheketanga?

Ko tētahi o ngā mea tino nui hei whakaroa i te koroheketanga ko te pupuri i tētahi momo noho hauora. Kei roto i tēnei ko te kai i tētahi kai taurite e whai kiko ana i ngā hua, huawhenua, witi katoa me te pūmua kikokore. Mā te karo i ngā kai tukatuka, te huka nui, me ngā ngako kino ka āwhina i te whakaiti i te mumura o te tinana me te tautoko i te hauora whānui. He mea nui anō hoki te noho makuku mā te inu i te nui o te wai hei pupuri i te hauora o te kiri me ngā okana.

Ko te whakakori tinana auau tētahi atu wāhanga matua o te oranga hauora, ā, ka āwhina i te whakaroa i te tukanga koroheketanga. Ka āwhina te whakakori tinana ki te whakapai ake i te hauora o te ngākau, te pupuri i te papatipu uaua, me te tautoko i te nekeneke me te ngāwari whānui. Mā te whai wāhi atu ki ngā mahi pēnei i te hikoi, te kaukau, te yoga, te whakangungu kaha rānei ka āwhina i tō tinana kia āhua taitamariki, kia kaha ake hoki.

Haunga te kai me te whakakori tinana, he mea nui te whakahaere i te ahotea hei whakaroa i te koroheketanga. Ka pā kino pea te ahotea mau tonu ki te tinana, ka piki ake te mumura me te ngoikore o te pūnaha ārai mate. Mā te whakamahi i ngā tikanga whakaiti ahotea pēnei i te whakaaroaro, te manawa hōhonu, te aroātahi rānei ka āwhina i te whakangā me te oranga whānui.

Ko tētahi atu āhuatanga nui o te whakaroa i te koroheketanga ko te moe nui. He mea nui te moe mō te whakatikatika me te whakaora i te tinana, ā, ki te kore e pai te moe, ka taea te koroheketanga wawe. Mā te whakarite i tētahi kaupapa moe auau me te waihanga i tētahi wā moe whakangāwari ka āwhina i te whakapai ake i te kounga o te moe me te tautoko i te hauora whānui.

Haunga ngā āhuatanga o te noho, he maha ngā maimoatanga hei āwhina i te whakaroa i te koroheketanga. Kei roto i ēnei ko ngā tikanga tiaki kiri, ngā tikanga whakapaipai, me ngā wawaotanga hauora. Mā te whakamahi i te hinu ārai rā me te whakamakuku i tō kiri ka āwhina i te ārai i ngā kino o te rā me te pupuri i te āhua taitamariki. Mā ngā tikanga whakapaipai pēnei i te Botox, ngā whakakī, me ngā maimoatanga taiaho ka āwhina hoki ki te whakaiti i te āhua o ngā kita me ngā raina angiangi.

Hei tāpiritanga, kei reira ētahi tāpiringa ārai-pakeketanga e wātea ana hei tautoko i te hauora me te ora whānui. Ko ētahi o ngā tāpiringa he nui ngā taunakitanga pūtaiao hei tautoko i tā rātou mahi ki te whakapai ake i te hauora mitochondrial me te whakaroa i te koroheketanga ko ngā NAD+ precursors me te urolithin A.

Ngā tāpiringa NAD+

I ngā wāhi kei reira ngā mitochondria, kei reira te NAD+ (nicotinamide adenine dinucleotide), he ngota e tika ana mō te whakanui ake i te whakaputanga pūngao. Ka heke noa te NAD+ i te pakeketanga, e rite ana ki te hekenga e pā ana ki te pakeketanga o te mahi mitochondrial.

E whakaatu ana ngā rangahau mā te whakanui ake i te NAD+, ka taea e koe te whakarei ake i te whakaputanga pūngao mitochondrial me te ārai i te ahotea e pā ana ki te koroheketanga. Tērā pea ka whakapai ake ngā tāpiringa NAD+ i te mahi uaua, te hauora o te roro, me te pākia o te tinana, me te whawhai pea ki ngā mate neurodegenerative. Hei tāpiri, ka whakaitihia e rātou te pikinga o te taumaha, ka whakapai ake i te aro ki te insulin, ka whakataurite i ngā taumata lipid, pērā i te whakaheke i te cholesterol LDL.

Koenzima Q10

Pērā i te NAD+, he mahi tika, he mahi nui hoki tā te coenzyme Q10 (CoQ10) i roto i te whakaputanga pūngao mitochondrial. Pērā i te astaxanthin, ka whakaitihia e te CoQ10 te ahotea waikura, he hua taha o te whakaputanga pūngao mitochondrial ka kino haere ina kore e pai te hauora o ngā mitochondria. Mā te tāpiringa CoQ10 ka whakaitihia te mōrearea o te mate ngakau, te whiu me te mate. I te mea ka heke te CoQ10 i te pakeketanga, mā te tāpiringa CoQ10 ka roa ake te ora o ngā kaumātua.

Urolithin A

Ka hangaia te Urolithin A (UA) e ō tātou huakita puku i muri i te kai i ngā polyphenols e kitea ana i roto i ngā kai pēnei i te pamekaranete, te rōpere, me te nati. Mā te tāpiringa UA i roto i ngā kiore pakeke ka whakahohe i ngā sirtuins, ka whakanui ake i te NAD+ me ngā taumata pūngao pūtau. He mea nui, kua whakaaturia te UA ki te whakakore i ngā mitochondria kua pakaru mai i ngā uaua tangata, ā, ka whakapai ake i te kaha, te ātete ki te ngenge, me te mahi hākinakina. Nō reira, ka taea e te tāpiringa UA te whakaroa i te roanga o te ora mā te ārai i te koroheketanga o ngā uaua.

Spermidine

Pērā i te NAD+ me te CoQ10, he ngota taiao te spermidine e heke ana i te pakeketanga. Pērā i te UA, ka hangaia te spermidine e ō tātou huakita puku, ā, ka whakaoho i te mitophagy – te tango i ngā mitochondria kino, kua pakaru. E whakaatu ana ngā rangahau kiore ka taea e te tāpiringa spermidine te tiaki i te mate ngakau me te koroheketanga uri wahine. Hei tāpiri, ko te spermidine kai (e kitea ana i roto i ngā momo kai tae atu ki te soy me ngā witi) i whakapai ake i te mahara o ngā kiore. Me nui ake ngā rangahau hei whakatau mena ka taea te tārua i ēnei kitenga i roto i te tangata.

He kaihanga kua rēhita ki te FDA a Suzhou Myland Pharm & Nutrition Inc. e whakarato ana i te paura urolithin A kounga teitei, he parakore hoki.

I Suzhou Myland Pharm, e whakapau kaha ana mātou ki te whakarato i ngā hua kounga teitei rawa atu i ngā utu pai rawa atu. Kua whakamatautauria te paura Urolithin A kia tino parakore, kia kaha hoki, kia whiwhi ai koe i tētahi tāpiringa kounga teitei ka taea e koe te whakawhirinaki. Ahakoa e hiahia ana koe ki te tautoko i te hauora pūtau, ki te whakapakari i tō pūnaha ārai mate, ki te whakarei ake rānei i te hauora whānui, ko tā mātou paura Urolithin A te whiringa tino pai.

Me te 30 tau o te wheako, me te mea hoki e ārahihia ana e te hangarau matatau me ngā rautaki R&D kua tino arotauhia, kua whakawhanakehia e Suzhou Myland Pharm he whānuitanga o ngā hua whakataetae, ā, kua riro hei kamupene auaha mō ngā tāpiringa pūtaiao koiora, te hanga ritenga me ngā ratonga hanga.

Hei tāpiritanga, he kaihanga kua rēhitatia ki te FDA a Suzhou Myland Pharm. He hou, he maha ngā mahi a ngā rauemi R&D a te kamupene, ngā whare whakaputa, me ngā taputapu tātari, ā, ka taea te whakaputa matū mai i te mirikaramu ki te tana i te tauine, me te tutuki i ngā paerewa ISO 9001 me ngā whakaritenga whakaputa GMP.