He aha koe me hoko ai i te paura Spermidine? Ngā Painga Matua kua Whakamāramahia

Spermidine,e mōhiotia ana ko te spermidine, he matū triamine polyamine e kitea whānuitia ana i roto i ngā tipu pēnei i te witi, te pīni soya, me te rīwai, ngā moroiti pēnei i te lactobacilli me te bifidobacteria, me ngā momo kiko kararehe. Ko te Spermidine he hauwaiwai me te anga waro āhua-pikopiko e titoa ana i te 7 ngā ngota waro me ngā rōpū amino i ngā pito e rua me waenganui.

Kua whakamātauhia e ngā rangahau hou te whai wāhi o te spermidine ki ngā tukanga ora nui pēnei i te tāruaruatanga DNA pūtau, te tuhi mRNA, me te whakamāoritanga pūmua, tae atu ki ngā tukanga pathophysiological maha pēnei i te tiaki i te ahotea o te tinana me te pākia o te tinana. He tiaki pūnaha cardiovascular me te tiaki io, he ārai i te pukupuku, me te whakahaere i te mumura, me ētahi atu. He mahi koiora nui.

E kiia ana ko te Spermidine he kaiwhakaoho kaha o te autophagy, he tukanga hangarua ā-roto e whakahoutia ai ngā pūtau tawhito, e hoki anō ai te mahi. He mahi nui tā te Spermidine ki te mahi me te oranga o ngā pūtau. I roto i te tinana, ka puta te spermidine mai i tōna pūmua putrescine, koia nei te pūmua o tētahi atu polyamine e kiia nei ko te spermine, he mea nui anō hoki ki te mahi a ngā pūtau.

Ka whakaoho te spermidine me te putrescine i te autophagy, he pūnaha e wawahi ana i ngā para o roto, e hangarua ana hoki i ngā wāhanga pūtau, ā, he tikanga whakahaere kounga mō ngā mitochondria, ngā whare kaha o te pūtau. Ka wawahia e te autophagy, ka whakakorea atu hoki ngā mitochondria kua pakaru, kua hapa rānei, ā, he tukanga tino whakahaeretia te whakakorenga mitochondria. Ka taea e ngā polyamine te here ki ngā momo ngota maha, ka maha ai ngā whakamahinga. Ka tautokohia e rātou ngā tukanga pēnei i te tipu pūtau, te pumau o te DNA, te tipu pūtau, me te apoptosis. Te āhua nei he rite tonu te mahi a ngā polyamine ki ngā mea whakatipu i te wā o te wehenga pūtau, koia te take he mea nui te putrescine me te spermidine ki te tipu me te mahi a te kiko hauora.

I rangahauhia e ngā kairangahau te tiaki a te spermidine i ngā pūtau mai i te ahotea waikura, ka taea te kino i ngā pūtau me te arahi ki ngā mate maha. I kitea e rātou ka whakahohe te spermidine i te autophagy. I tautuhia e te rangahau ētahi ira matua e pāngia ana e te spermidine e whakaiti ana i te ahotea waikura me te whakatairanga i te autophagy i roto i ēnei pūtau. Hei tāpiri, i kitea e rātou ko te aukati i te ara mTOR, e whai wāhi ana ki te aukati i te autophagy, ka whakanui ake i ngā pānga tiaki o te spermidine.

Ko ēhea ngā kai he nui te spermidine?

He polyamine nui te Spermidine. Haunga te hanga e te tinana tangata tonu, ko ōna puna kai maha me ngā moroiti puku he ara matua hoki mō te tuku. He rerekē te nui o te spermidine i roto i ngā momo kai, ā, ko te ira witi he puna tipu rongonui. Ko ētahi atu puna kai ko te karepe, ngā hua soya, ngā pīni, te kānga, ngā witi katoa, ngā pīni kikī, ngā pī, ngā pepa matomato, te pūrokoro, te karaka, te tī matomato, te parai raihi me ngā pepa matomato hou. Hei tāpiri, kei roto hoki i ngā kai pēnei i te harore shiitake, ngā purapura amaranth, te kūmara, te tiihi pakeke me te durian.

He mea tika kia mōhiotia ko te kai Mediterranean he nui ngā kai whai kiko i te spermidine, ā, tera pea ka āwhina i te whakamārama i te āhuatanga "rohe kikorangi" e roa ake ai te ora o te tangata i ētahi wāhi. Heoi, mō te hunga kāore e taea te kai i te spermidine i roto i te kai, he huarahi whai hua ngā tāpiringa spermidine. Ko te spermidine i roto i ēnei tāpiringa he rite tonu te ngota ngota tūturu, ā, he huarahi whai hua.

He aha te putrescine?

E rua ngā ara e whakamahia ana mō te whakaputanga o te putrescine, ā, ka tīmata ēnei ara e rua ki te waikawa amino arginine. I te ara tuatahi, ka hurihia tuatahitia te arginine ki te agmatine mā te arginine decarboxylase. Muri iho, ka hurihia anō te agmatine ki te N-carbamoylputrescine mā te mahi a te agmatine iminohydroxylase. Ā tōna wā, ka hurihia te N-carbamoylputrescine ki te putrescine, ka oti te tukanga whakawhiti. He tino māmā te ara tuarua, ka hurihia tika te arginine ki te ornithine, kātahi ka hurihia te ornithine ki te putrescine mā te mahi a te ornithine decarboxylase. Ahakoa he rerekē ngā taahiraa o ēnei ara e rua, i te mutunga ka tutuki i a rāua te whakawhiti mai i te arginine ki te putrescine.

Ko te putrescine he diamine e kitea ana i roto i ngā momo whekau pēnei i te pancreas, te thymus, te kiri, te roro, te kōpū me ngā ovaries. E kitea whānuitia ana hoki te putrescine i roto i ngā kai pēnei i te witi, te pepa matomato, te pīni soya, te pistachios, me te karaka. Kua whakaatuhia e ngā rangahau tata nei ko te putrescine he matū whakahaere nui o te pākia o te tinana ka taea te taunekeneke ki ngā macromolecules koiora pēnei i te DNA kua utua kinotia, te RNA, ngā momo ligands (pēnei i ngā kaiwhakawhiwhi adrenergic β1 me te β2), me ngā pūmua membrane. , e arahi ana ki te raupapa o ngā huringa ā-tinana, ā-mate rānei i roto i te tinana.

Pānga o te Spermidine

Ngā mahi ārai-ātete: He kaha te mahi ārai-ātete o te Spermidine, ā, ka taea e ia te tauhohe ki ngā rauropi kore utu hei whakaiti i te kino o te waikura ki ngā pūtau i puta mai i ngā rauropi kore utu. I roto i te tinana, ka taea hoki e te spermidine te whakatairanga i te whakaaturanga o ngā whākōkī ārai-ātete me te whakarei ake i te kaha ārai-ātete.

Te whakahaere i te pākia o te pūngao: Kei roto te Spermidine i te whakahaere i te pākia o te pūngao o ngā rauropi, ka taea te whakatairanga i te mimiti me te whakamahinga o te hukahuka i muri i te kai, ā, ka pā ki te ōwehenga o te pākia aerobic me te pākia anaerobic mā te whakahaere i te whai huatanga o te whakaputa pūngao mitochondrial.

pānga ārai-mumura

He pānga ārai-mumura tō te Spermidine, ā, ka taea e ia te whakahaere i te whakaaturanga o ngā āhuatanga mumura me te whakaiti i te putanga mai o te mumura mau tonu. E pā ana ki te ara nuclear factor-κB (NF-κB) te nuinga.

Te tipu, te whanaketanga me te whakahaere i te ārai mate: He mahi nui anō tā te Spermidine ki te tipu, te whanaketanga me te whakahaere i te ārai mate. Ka taea e ia te whakatairanga i te whakaputanga o te homoni tipu i roto i te tinana tangata, ā, ka āwhina i te whakarei ake i te whanaketanga o ngā kiko me ngā okana o te tinana. I taua wā anō, i roto i te whakahaere i te ārai mate, ka whakarei ake te spermidine i te ātete o te tinana ki ngā huaketo me ngā mate mā te whakahaere i te hanga o ngā pūtau toto mā me te whakatairanga i te tango i ngā momo hāora tauhohe.

Ka whakaroa i te koroheketanga: Ka taea e te Spermidine te whakatairanga i te autophagy, he tukanga horoi i roto i ngā pūtau e āwhina ana ki te tango i ngā whekau me ngā pūmua kua pakaru, ā, ka whakaroa i te koroheketanga.

Te whakahaere i ngā pūtau glial: He mahi whakahaere nui tā te Spermidine i roto i ngā pūtau glial. Ka taea e ia te whai wāhi ki ngā pūnaha tohu pūtau me ngā hononga mahi i waenga i ngā pūtau io, ā, he mahi whakahaere nui anō hoki i roto i te whanaketanga o ngā neuron, te tuku hononga synaptic, me te ātete ki te neuropathy.

Te tiaki i te ngākau: I roto i te mara o te ngākau, ka taea e te spermidine te whakaiti i te kohikohinga lipid i roto i ngā papa atherosclerotic, te whakaiti i te hypertrophy o te ngākau, me te whakapai ake i te mahi diastolic, kia tutuki ai te tiaki i te ngākau. Hei tāpiri, ko te kai spermidine ka whakapai ake i te toto toto me te whakaiti i te mate me te mate o te ngākau.

I te tau 2016, i whakaūtia e ngā rangahau i whakaputaina ki roto i te Atherosclerosis ka taea e te spermidine te whakaiti i te kohikohinga lipid i roto i ngā papa atherosclerotic. I taua tau anō, i whakaūtia e tētahi rangahau i whakaputaina ki roto i te Nature Medicine ka taea e te spermidine te whakaiti i te hypertrophy o te ngakau me te whakapai ake i te mahi diastolic, mā te tiaki i te ngakau me te whakaroa i te roanga o te oranga o ngā kiore.

Whakapai ake i te mate a Alzheimer

He pai te kai o te spermidine ki te mahi mahara o te tangata. I kitea e te tīma o Ahorangi Reinhart o Ahitereiria ka taea e te maimoatanga spermidine te whakapai ake i te mahi hinengaro o ngā kaumātua. I whakamahia e te rangahau he hoahoa matapo-rua maha-pokapū, ā, i whakaurua e 85 ngā kaumātua ki roto i ngā whare tiaki kaumātua e 6, i wehea matapōkeretia kia rua ngā rōpū, ā, i whakamahia ngā horopeta rerekē o te spermidine. I aromatawaihia ā rātou mahi hinengaro mā roto i ngā whakamātautau mahara, ā, i wehea kia whā ngā rōpū: kāore he mate wareware, he mate wareware ngawari, he mate wareware ngawari me te mate wareware kino. I kohia ngā tauira toto hei aromatawai i te kukū o te spermidine i roto i ō rātou toto. I whakaatuhia e ngā hua he hononga nui te kukū o te spermidine ki te mahi hinengaro i roto i te rōpū kāore i te mate wareware, ā, i tino pai ake te taumata hinengaro o ngā kaumātua me te mate wareware ngawari ki te ngawari i muri i te kai i ngā horopeta teitei o te spermidine.

Autophagy

Ka taea e te Spermidine te whakatairanga i te autophagy, pērā i te ara aukati mTOR (target of rapamycin). Mā te whakatairanga i te autophagy, ka āwhina i te tango i ngā whekau me ngā pūmua kua pakaru i roto i ngā pūtau, ā, ka pupuri i te hauora o te pūtau.

E whakamahia ana te Spermidine hydrochloride i roto i ngā mara maha

I roto i te ao rongoā, ka whakamahia te spermidine hydrochloride hei rongoā tiaki ate ka taea te whakapai ake i te mahi ate me te whakaiti i te kino o te ate. Hei tāpiri, ka taea te whakamahi i te spermidine hydrochloride hei rongoā i ngā āhuatanga pēnei i te cholesterol teitei, te hypertriglyceridemia, me te mate ngakau.

Mā te whakaiti i ngā taumata homocysteine ​​​​(Hcy) i roto i te toto, ka whakaitihia te mōrearea o te mate ngakau. Kua whakaatuhia e ngā rangahau ka taea e te spermidine hydrochloride te whakatairanga i te pākia o te Hcy me te whakaiti i te mōrearea o te mate ngakau mā te whakaiti i ngā taumata Hcy i roto i te toto.

I whakaatuhia i roto i tētahi rangahau mō ngā pānga o te spermidine hydrochloride ki te mōrearea o ngā mate pūnaha toto, ka taea e te spermidine hydrochloride te whakaiti i ngā taumata Hcy plasma, ā, ka whakaiti i te mōrearea o te mate pūnaha toto. I roto i te rangahau, i wehea e ngā kairangahau ngā kaiuru ki ngā rōpū e rua, ko tētahi i whiwhi i te tāpiringa spermidine hydrochloride, ko tētahi i whiwhi i te placebo.

I whakaatuhia e ngā hua o te rangahau he iti ake ngā taumata Hcy plasma o ngā kaiuru i whiwhi tāpiringa spermidine hydrochloride, ā, he rite tonu te hekenga o te mōrearea o te mate ngakau. Hei tāpiri, kei reira ētahi atu rangahau e tautoko ana i te mahi a te spermidine hydrochloride ki te whakaiti i te mōrearea o te mate ngakau.

I roto i te ao kai, ka whakamahia te spermidine hydrochloride hei whakarei ake i te reka me te whakamakuku hei whakarei ake i te reka o te kai me te pupuri i te makuku o te kai. Hei tāpiri, ka taea hoki te whakamahi i te spermidine hydrochloride hei tāpiringa kai hei whakapai ake i te tere tipu me te kounga uaua o ngā kararehe.

I roto i ngā mahi whakapaipai, ka whakamahia te spermidine hydrochloride hei whakamakuku me te ārai mate hei pupuri i te makuku o te kiri, hei whakaiti hoki i te kino o ngā rauropi kore utu. Hei tāpiri, ka taea hoki te whakamahi i te spermidine hydrochloride i roto i ngā hinu ārai rā hei whakaiti i te kino o ngā hihi ultraviolet ki te kiri.

I roto i te mara ahuwhenua, ka whakamahia te spermidine hydrochloride hei kaiwhakahaere tipu tipu hei whakatairanga i te tipu o ngā hua me te whakapiki i ngā hua.