BAM15A CAS Nama:210302-02-6 Hanga uaua, whakaiti ngako.
Ngā Tawhā Hua
| Ingoa hua | BAM15A |
| Ingoa kē atu | N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Nama CAS | 210302-02-6 |
| Tātai ngota | C16H10Cl2N6O |
| Taumaha ngota | 373.2 |
| Te parakore | 98% |
| Āhua | Paura māwhero ki te kōwhai mārama |
| Te tākai | 1kg/pēke, 25kg/peera |
| Tono | Rauemi Mata o te Tāpiringa Kai |
Whakataki hua
He kaiwhakatikatika mitochondrial hou te BAM15A. Hei kaiwhakawehe i te hononga proton mitochondrial pai rawa atu, ka āta whakahaere i te pikinga proton puta noa i te kiriuhi mitochondrial o roto, ka whakanui ake i te whai huatanga o te pākia o te pūngao o te tinana, ā, ka tere ake te pakaru waikura taiao o te ngako, me te kore e pā ki te papatipu uaua, ki te hiahia noa rānei.
Kua whakaūtia e ngā rangahau haumanu-mua he āwhina tēnei kai ki te whakapai ake i te pupuhi o te tinana, te whakanui ake i te aro o te insulin, te whakaiti i te kohikohinga ngako ate, me te whakamamae i ngā urupare mumura pūnaha. E 67% te kaha o tōna urunga ki te tinana, ā, he ngawari hoki ōna āhuatanga me te haumaru teitei. He rerekē ki ngā kai tuku iho, kāore e puta he pāmahana tinana rerekē, he kino rānei ki ngā pūtau, ā, he rauemi mata kai pai rawa atu tēnei mō te whakahaere taumaha me te whakahaere i te pākia o te tinana.
Āhuatanga
(1) Teitei te parakore: BAM15Aka taea te whakaputa hua parakore teitei mā te tukanga whakaputa kua whakatikatikaina. Ko te tikanga o te parakore teitei he pai ake te waatea o te koiora.
(2) Tikanga wetewete whai hua: Hei kawe i te pūmua mitochondrial, ka whakararuraru i te pikinga pūmua o te kiriuhi mitochondrial o roto, ka whakatairanga i te hurihanga o te pūngao waikura mai i ngā matūkai ki te pūngao wera kaua ki te ATP, ka tino whakanui ake i te whakapaunga pūngao.
(3) Te whakahekenga ngako haumaru me te whakapai ake i te pākia o te tinana: I roto i ngā whakamātautau kararehe, i eke te bioavailability ā-waha ki te 67%, ka whakaiti i te ngako tinana neke atu i te 20% me te kore e whakaiti i te papatipu uaua, ka pā ki te hiahia kai, ki te pāmahana tinana rānei, me te whakapai ake i te aro ki te insulin, te whakaiti i te ate momona me te mumura.
(4) Painga iti te paitini: Ki te whakatauritea ki ngā kaihoko wetewete tuku iho, kāore he mōrearea o te kirika nui, te paitini pūtau rānei, ā, kāore he kino o ngā okana, ngā pānga taha pūnaha io rānei..
Ngā tono
1. Te whakaiti i te ngako me te whakapai ake i te pākia o te tinana: Mā te wetewete i te hononga o ngā mitochondrial, ka tino whakaitihia te ngako tinana (i roto i ngā tauira kararehe, ka heke te ngako tinana neke atu i te 20%), ka whakaitihia hoki te huka toto, te ātete ki te insulin, me te kohikohinga ngako ate, me te kore e pā ki te hiahia kai, ki te papatipu uaua rānei;
2. Ārai i te koroheketanga: Whakarei ake i te papatipu uaua (mā te 8%) me te kaha (mā te 40%) i roto i ngā kararehe kaumātua, whakaiti i te ngako me te aukati i te mumura mau tonu, me te whawhai ki te momona myogenic.
3. Ārai-mumura: Ka whakaiti i te mōrearea o te whara whatukuhu whakapeka (AKI) i puta mai i te sepsis, ā, ka whakamama i ngā urupare mumura pūnaha mā te aukati i te hanga ROS mitochondrial me te tukunga mtDNA.
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