O-304 CAS No.:1261289-04-6 Hanga uaua, whakaiti ngako.
Ngā Tawhā Hua
| Ingoa hua | O-304 |
| Ingoa kē atu | 4-Kōro-N-[2-[(4-kōropeneira)metil]-2,3-dihidro-3-okso-1,2,4-tiadiazol-5-il]benzamida |
| Nama CAS | 1261289-04-6 |
| Tātai ngota | C16H11Cl2N3O2S |
| Taumaha ngota | 380.25 |
| Te parakore | 98% |
| Āhua | Paura mā ki te paura mā-parauri |
| Te tākai | 1kg/pēke, 25kg/peera |
| Tono | Rauemi Mata o te Tāpiringa Kai |
Whakataki hua
He kaiwhakaoho AMPK ngota iti te O-304 e whakarei ake ana i te mahi AMPK mā te aukati i te tangohanga o te phosphorylation o te AMPK phosphorylated (pAMPK), ā, ka whakanui ake i ngā taumata pAMPK me te kore e whakaiti i ngā kukū adenosine triphosphate (ATP) i roto i te pūtau. He maha ngā tikanga mahi a ia, tae atu ki te whakapai ake i te pākia o te huka, te whakaiti i te ātete ki te insulin, me te tiaki i te pūnaha manawa.
Āhuatanga
(1) Teitei o te parakore: Ka hangaia te O-304 mā te tukanga hanga kua whakatikatikaina, kia eke ki te teitei o te parakore o te hua. Ko te tikanga o te parakore nui ake he pai ake te wātea o te koiora.
(2) Ngā Mahi Koiora:He kaiwhakaoho ā-waha a O-304 o te AMPK (AMP-activated protein kinase). Ka whakarei ake i te mahi AMPK mā te aukati i te tangohanga o te pAMPK.
Ngā tono
1. Whakahohenga AMPK: Ka whakanuia e te O-304 te mahi AMPK mā te aukati i te tukanga tangohanga phosphorylation o te AMPK kua phosphorylated (pAMPK), ā, mā reira ka whakahaere i te taurite o te pākia o te pūngao.
2. Te whakapai ake i te pākia o te huka toto: I roto i ngā rangahau kararehe, i āwhina te horopeta o te 100 mg/kg o te O-304 ki te pupuri i te taumata huka toto nohopuku me te taumata insulin plasma, me te whakaiti nui i te taumahatanga pākia e puta mai ana i te kai nui-ngako, me te ārai i ngā piki me ngā heke o te huka toto me te pikinga o te insulin rerekē i puta mai i ngā koretake o te kai.
3. Pte tiaki i te ngāwari o ngā oko toto:Ka āwhina te O-304 ki te pupuri i te toto toto ki ngā taumata hauora, ka whakaiti i te ahotea ki ngā oko toto, ā, ka whakarato i te tiakitanga ngawari mō te wā roa mō ngā pūnaha ngakau me te roro, me te tautoko i te pumau o ngā kare ā-roto me te pūngao pumau.
4.Te whakatairanga i te taitamarikitanga pumau:Ka aro tika a O-304 ki te ara tohu AMPK-mTOR, ka whakahaere atamai i te tukanga o te autophagy pūtau, ka whakatairanga i te catabolism o ngā pūmua kua koroheketia me ngā lipids rerekē, me te pupuri i te taiao pūtau ma, oraora hoki, ā, ka whakaroa i te koroheketanga pūtau.
