SLU-PP-332 Nama CAS: 303760-60-3
Ngā Tawhā Hua
| Ingoa hua | SLU-PP-332 |
| Ingoa kē atu | SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide；Waikawa 4-Hydroxybenzoic 2-(2-naphthalenylmethylene)hydrazide； |
| Nama CAS | 303760-60-3 |
| Tātai ngota | C18H14N2O2 |
| Taumaha ngota | 290.32 |
| Te parakore | 98% |
| Āhua | Paura mā, paura mā-parauri rānei |
| Te tākai | 1kg/pēke, 25kg/peera |
| Tono | Rauemi Mata o te Tāpiringa Kai |
Whakataki hua
He matū ngota iti hou a SLU-PP-332 e mahi ana hei kaiwhakawhiwhi estrogen perifollicle (ERR) agonist, e aro nui ana ki a ERRα, ERRβ, me ERRγ, me te pānga whakahohenga kaha rawa atu ki a ERRα (EC₅₀=98 nM). Ka whakahohehia e tēnei matū te ara tohu ERR mā te whai i ngā tikanga whakahaere pākia o te whakakori tinana, ā, ka whakarerekē i te pākia o te pūngao, te mahi mitochondrial, me te manawanui o te uaua.
Āhuatanga
(1) Tikanga mahi: whakahohe i te ERRα/β/γ, whakanui ake i te whakahāngaitanga waikawa ngako (FAO) me ngā ira e pā ana ki te manawa mitochondrial, whakatairanga i te pakaru ngako hei whakarato pūngao, whakaiti i te kohikohinga ngako, whakarei ake i te mahi mitochondrial uaua angaanga, whakapai ake i te kaha whakahāngaitanga me te manawanui, he rite ki te pānga o te whakangungu aerobic.
(2) Te mahi koiora: a) Ngā pānga o te tauira kararehe: Ngā kiore momona: i muri i ngā rā 28 o te rongoā, kua heke te taumaha o te tinana mā te 12%, ā, kua tino heke te ngako ate, te cholesterol, me ngā triglycerides; ngā kiore noa: kua piki ake te wā oma mā te 70%, kua piki ake te tawhiti mā te 45%, me te kore e pā ki te hiahia kai, ki te nekehanga tūao rānei. b) Haumaru: kāore i kitea he pānga kino kino i roto i ngā rangahau haumanu-mua.
(3) Ngā āhuatanga ā-tinana me te matū: he mā ki te mā te totoka, he wairewa ki te DMSO (75 mg/mL) me te etanoru, kāore e wairewa ki te wai; me penapena ki te pōuri..
Ngā tono
Mā te SLU-PP-332 ka taea te whakaiti i te ngako me te whakahaere i te huka toto mā te whakatairanga i te waikura ngako me te whakapai ake i te aro o te insulin; ka whakapai ake i te mate ate ngako kore-waipiro (NAFLD), ka whakaiti i te nui o te ngako ate; ka tautoko i te pākia o te tinana mō te hunga kāore e taea te whakakorikori tinana, te pupuri i te papatipu uaua me te mahi; ka whakaiti i te ngaronga uaua i te wā o te tukanga whakaiti ngako; ā, he whānui ngā tirohanga ki ngā wāhanga o te whakaiti ngako, te whakarei ake i te manawanui, me te whakapai ake i te pākia o te tinana.
