5-Amino-1-methylquinolinium iodide（NNMTi） Nama CAS:42464-96-0 98.0% te parakore iti rawa | kaihanga kai tāpiringa
Ngā Tawhā Hua
| Ingoa hua | 5-Amino-1-methylquinolinium iodide（NNMTi） |
| Ingoa kē atu | NNMTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide 5-Amino-1-mq iodide |
| Nama CAS | 42464-96-0 |
| Tātai ngota | C10H11IN2 |
| Taumaha ngota | 286.11 |
| Te parakore | 98.0% |
| Āhua | Parauri ki te parauri whero totoka |
| Te tākai | 1kg/pēke, 25kg/peera |
| Tono | Rauemi Mata o te Tāpiringa Kai |
Whakataki hua
Kua kitea houtia te whākōkī cytosolic nicotinamide N-methyltransferase (NNMT) hei whakahaere i ngā taumata o ngā matū mua o te nicotinamide e hiahiatia ana mō te hanga NAD+, nō reira he mahi nui tāna ki te whakahaere i te ara whakaora NAD+ me te pākia o te pūtau. Ka whakaatuhia te NNMT i roto i te uaua angaanga, ā, ka piki haere tōna whakaaturanga me te koroheketanga o te kiko uaua. He mea nui, ko te NNMT tētahi wāhanga nui o te waitohu whakaaturanga ira sarcopenic, ā, ko tōna whakaaturanga nui ka arahi pea ki te hekenga nui o ngā taumata NAD+ me te hekenga o te papatipu uaua, te kaha, me te mahi e haere tahi ana me te koroheketanga. Ko te maimoatanga o ngā kiore kua pakeke me te aukati NNMT ngota iti (NNMTi) i whakarei ake i te kaha tipu, te whakakotahitanga, me te whakaora o ngā muSC, ā, ka whakapai ake i te mahi a te uaua angaanga. I whiwhihia ngā hua rite i roto i te vitro mā te whakamahi i ngā pūtau C2C12, he tino rite ki ngā muSC, i reira i whakatairangahia ai e te maimoatanga NNMTi te rerekētanga myoblast me te tautoko i ngā huringa pākia i roto i ngā metabolites pūtau e pā ana ki te ara whakaora NAD+.
Ko te NNMTi he whākōkī e nui rawa ana te whakaputanga i te wā e pakeke haere ana ngā uaua angaanga, ā, e pā ana ki te kino o te ara NAD+, te koretake o te mahi sirtuin1, me te pikinga o te koroheketanga o ngā pūtau take uaua. Ko te NNMT he whākōkī pākia e whakaoho ana i te methylation o te nicotinamide (NAM) mā te whakamahi i te kaituku methyl whānui S-adenosylmethionine (SAM), e hono ana i te āhua pākia o te pūtau ki te toenga methylation me ngā taumata NAD+ ā-roto. He nui te whakaputanga o te NNMT i roto i te ate me te kiko ngako, tae atu ki ngā āhuatanga mate e tohuhia ana e te pikinga o ngā tono pākia, pērā i ētahi mate ate momona me te mate huka. Kei roto te NNMT i roto i ngā tukanga rerekētanga maha, tae atu ki te whakawhiti pūtau take kukune tangata mai i te tīmatanga ki te pakeke, te myogenesis, me ngā whakawhiti epithelial me te neuromesenchymal i roto i ngā momo mate pukupuku. Ka whakahaerehia te whakaputanga o te NNMT i roto i te tikanga kiko-me-te-horopaki, kaua i te tauira whakahaere whānui.
Āhuatanga
(1) Teitei o te parakore: Ka taea e te NNMTi te whiwhi hua tino parakore mā roto i ngā tukanga whakaputa kua whakatikatikaina. Ko te tikanga o te tino parakore he pai ake te waatea o te koiora.
(2) Te arotahi: Ka arotahi motuhake a NNMTi ki te whākōkī NNMT, ā, ka taea te aukati i tana mahi, ā, ka pā ki te ara pākia o te nicotinamide.
(3) Te Pūmautanga: He pai te pumau o te NNMTi, ā, ka taea e ia te pupuri i tana mahi me tana pānga i raro i ngā taiao me ngā tikanga rokiroki rerekē.
(4) Ngā tūmanakohanga whanaketanga: Nā ngā āhuatanga rerekē o te NNMTi, kua arohia whānuitia tōna whanaketanga, ā, he whānui hoki ngā tūmanakohanga rangahau me te tono.
Ngā tono
Ko te NNMTi (CAS 42464-96-0) he aukati nicotinamide N-methyltransferase (NNMT), he aukati kaha (IC50=1.2 μM) o te nicotinamide N-methyltransferase (NNMT) e whakatairanga ana i te rerekētanga o te myoblast. Ka herea motuhaketia e te NNMTi ki ngā toenga pae herenga NNMT. Ka whakatairanga te NNMTi i te rerekētanga o te myoblast i roto i te vitro, ā, ka whakarei ake i te whakakotahitanga pūtau take uaua me te whakahoutanga i roto i ngā kiore pakeke. Ko te NNMT he whākōkī biotransformation cytosolic taketake e whakaoho ana i te N-methylation o ngā xenobiotics taketake me ngā xenobiotics exogenous. Ki te whakatauritea ki te whakakapinga kai kikokore anake, ko te maimoatanga NNMT me te whakakapinga kai kikokore i tere ake te whakapai ake i te ngaronga ngako tinana, te whakanui ake i te ōwehenga papatipu kikokore tinana katoa ki te taumaha tinana, te whakaiti i te taumaha kiko ngako ma epididymal ate, te whakaiti i te whakatakotoranga ngako ate, me te whakapai ake i te steatosis ate. Hei tāpiri, ka taea e te NNMTi te whakanui ake i te kaha me te whakatairanga i te kaha whakaora o te uaua pakeke, he mea whai hua pea mo te maimoatanga o te sarcopenia.
