Kaihanga paura CMS121 Nama CAS: 1353224-53-9 98.0% te parakore iti rawa mō ngā kai tāpiringa
Ngā Tawhā Hua
| Ingoa hua | CMS121 |
| Ingoa kē atu | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoACarboxylase,mate,tiaki roro,ārai,ārai-mumura,mitochondrial,Alzheimer's,ārai-waikura,acetylation,Ārai,H3K9,Acetyl-CoACarboxylase,CMS121,mate wareware,ACC1,CMS-121 |
| Nama CAS | 1353224-53-9 |
| Tātai ngota | C20H19NO3 |
| Taumaha ngota | 321.37 |
| Te parakore | 98.0% |
| Āhua | Paura kōwhai mārama |
| Tono | Rauemi Mata o te Tāpiringa Kai |
Whakataki hua
Ko te 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol he matū e kiia ana ko CMS121. E kī ana te uaua o te hanganga o te matū he āhuatanga ahurei pea ōna me ngā whakamahinga pea. Hei mārama ki tōna hiranga, he āwhina ki te tautuhi i ngā rōpū mahi e wātea ana me te tātari i ō rātou pānga pea. E kī ana te noho mai o te mowhiti quinoline he kaha te kaha o te matū ki te taha koiora. E mōhiotia ana ngā ngota i ahu mai i te quinoline mō ō rātou āhuatanga koiora kanorau, tae atu ki ngā mahi patu huakita me te ārai-mumura. Mā te piri o te rōpū cyclopentyloxy ka whai wāhi pea ki te wairewatanga o te matū, ki te whakarei ake rānei i tōna mahi koiora mā roto i ngā pānga steric. I roto i ngā rangahau mō ngā pūtau HT22, kua whakaatuhia e te CMS-121 ngā pānga tiaki-ira nui, e tiaki pai ana i ēnei pūtau mai i te ischemia me te kino oxidative. Hei tāpiri, he āhuatanga ārai-mumura nui tō te CMS-121, e tohu ana i tōna kaha ki te whakarerekē i ngā urupare mumura. Mā te mahi pera, ka taea e te CMS-121 te whakaiti i te mumura i roto i ngā momo kiko me ngā okana. He kaha te mahi rongoā a te CMS-121 hei aukati i te acetyl-CoA carboxylase 1 (ACC1). Nā tōna pānga aukati kaha ki te ACC1 ka waiho hei matū whai hua.
Āhuatanga
(1) Teitei o te parakore: Ka taea e te CMS-121 te whiwhi hua tino parakore mā roto i ngā tukanga whakaputa kua whakatikatikaina. Ko te tikanga o te tino parakore he pai ake te wātea o te koiora me te iti ake o ngā urupare kino.
(2) Haumarutanga: He tino haumaru, he iti noa ngā pānga kino.
(3) Te Pūmautanga: He pai te pumau o te CMS-121, ā, ka taea e ia te pupuri i tōna kaha me tōna pānga i raro i ngā taiao me ngā tikanga rokiroki rerekē.
Ngā tono
He hua quinolone te CMS-121, he aukati acetyl-CoA carboxylase 1 (ACC1) e kaha ana ki te waha, ā, he pai ngā āhuatanga rongoā. He nui ngā rangahau kua mahia hei tirotiro i ngā painga pea o te CMS-121 i roto i ngā momo wāhanga, tae atu ki te tiaki io, ngā pānga ārai-mumura, te mahi antioxidant, me tōna pānga ki ngā tohu e pā ana ki te koroheketanga hauora.
