Kaihanga paura Lemairamin (WGX-50) Nama CAS: 29946-61-0 98.0% te parakore iti rawa mō ngā kai tāpiringa
Ataata Hua
Ngā Tawhā Hua
| Ingoa hua | Lemairamin |
| Ingoa kē atu | 2-Pōpenemirama, N-[2-(3,4-dimetoksifeni)etiri]-3-fenirama-, (2E)-; Lemairamin (WGX-50) |
| Nama CAS | 29946-61-0 |
| Tātai ngota | C19H21NO3 |
| Taumaha ngota | 311.37 |
| Te parakore | 98.0% |
| Āhua | Paura mā ki te paura mā-parauri |
| Tono | Rauemi Mata o te Tāpiringa Kai |
Whakataki hua
Ko Lemairamin, ko Wgx50 rānei, he matū taiao i tangohia mai i ngā pepa tiri, ā, kua whakaatu i ngā hua pai mō te ārai i te mate a Alzheimer. Kua kitea e ngā rangahau ka taea e ia te aukati i te apoptosis neuronal i puta mai i te Aβ, te whakaiti i te paitini konupūmā neuronal, me te whakaiti i te kohikohinga o ngā oligomers Aβ i roto i te cortex roro. Hei tāpiri, kua whakaaturia te wgx50 hei whakapai ake i te mahi hinengaro i roto i ngā kiore. E kī ana ngā rangahau he kaha tō te wgx50 ki te aukati i te huihuinga pūmua-pūmua i waenga i ngā ngota amyloid. I te nuinga, he kaha tō te wgx50 ki te ārai i te mate a Alzheimer, ā, tera pea ka whakaratohia he huarahi hou mō te whakawhanaketanga o ngā rongoā e aro ana ki ngā oligomers Aβ. Hei tāpiri, he nui te mahi ārai-mumura o te WGX-50, e waiho ana hei kaitono pai mō te rongoā i ngā mate mumura. Kua kitea he pānga nui tō te WGX-50 ki te kiri, pērā i te whakaiti i ngā kita me te whakapai ake i te ngāwari o te kiri. Haunga ngā matū taiao i tangohia mai i te tipu Zanthoxylum bungeanum, he maha atu ngā matū hangai e whakamahia ana i roto i ngā tono maha, ā, he pai ake mō te mākete.
Āhuatanga
(1) Teitei o te parakore: Ka taea e Lemairamin te whiwhi hua tino parakore mā roto i ngā tukanga whakaputa tangohanga me te whakamahine taiao. Ko te tikanga o te tino parakore he pai ake te wātea o te koiora me te iti ake o ngā urupare kino.
(2) Haumaru: He tino haumaru, he iti noa ngā pānga kino, kāore he pānga kino e kitea ana ahakoa te whakamahinga roa.
(3) Te Pūmautanga: He pai te pumau o Lemairamin, ā, ka taea e ia te pupuri i tana mahi me tana pānga i raro i ngā taiao me ngā tikanga rokiroki rerekē.
(4) Ngāwari ki te mimiti: Ka taea e te tinana tangata te mimiti wawe i te Lemairamin, ā, ka tohatohahia ki ngā momo kiko me ngā okana.
Ngā tono
He matū amide te Lemairamin i tangohia mai i te kiri o te tipu Zanthoxylum bungeanum. E whakamahia ana i tēnei wā hei tāpiringa kai, ā, he agonist anō hoki mō te alpha7 nicotinic acetylcholine receptor (α7nAChR), e whakaiti ana i te mumura o te roro i roto i te mate a Alzheimer, ā, he mea hanga katoa. Kua whakaatuhia e Wgx50 ngā hua whakatenatena i roto i ngā rangahau haumanu-mua, tae atu ki te aukati i te apoptosis neuronal i puta mai i te Aβ, te whakaiti i te paitini konupūmā neuronal, te whakaiti i te kohikohinga o ngā oligomers Aβ i roto i te cortex roro, me te whakapai ake i te mahi hinengaro i roto i ngā kiore.
